INT89384

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.37
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (INS, AKT1) carbohydrate metabolic process (INS, AKT1) cell differentiation (AKT1)
nucleoplasm (AKT1) transport (AKT1) protein modification process (AKT1)
INS (Homo sapiens)
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 15 83.68 Quite High
Inflammation 29 50.00 Quite Low
COX-2 inhibitor 1 40.44 Quite Low
Pain 1 25.00 Low Low
COX2 1 24.00 Low Low
Kinase C 10 5.00 Very Low Very Low Very Low
bradykinin 3 5.00 Very Low Very Low Very Low
spinal inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 89 96.20 Very High Very High Very High
Hyperglycemia 38 92.36 High High
Necrosis 5 91.24 High High
Cancer 4 90.88 High High
Insulin Resistance 31 85.04 High High
Stress 33 76.96 Quite High
INFLAMMATION 29 50.00 Quite Low
Diabetes Mellitus 83 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 19 5.00 Very Low Very Low Very Low
Adhesions 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin-stimulated phosphatidylinositol (PI) 3-kinase, Akt (protein kinase B) serine phosphorylation, and Akt activity were reduced 34, 65, and 20%, respectively, after ECC (P < 0.05).
Negative_regulation (reduced) of Insulin Positive_regulation (stimulated) of Akt
1) Confidence 0.36 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.60 Pain Relevance 0.04
All these metabolic alterations are associated with an increase in caspase-3 activity and an impaired ability of insulin at a physiological concentration to activate Akt.
Negative_regulation (impaired) of insulin Positive_regulation (activate) of Akt
2) Confidence 0.03 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 0.78 Pain Relevance 0

General Comments

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