INT89392

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 15.69
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
muscle 2
skeletal muscle 2
keratinocytes 2
MDA-MB-231 2
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 45 99.72 Very High Very High Very High
Pain 9 99.72 Very High Very High Very High
antagonist 64 98.84 Very High Very High Very High
COX2 2 98.56 Very High Very High Very High
cINOD 63 97.32 Very High Very High Very High
dexamethasone 8 96.76 Very High Very High Very High
agonist 23 95.92 Very High Very High Very High
qutenza 12 94.72 High High
addiction 12 94.00 High High
mu opioid receptor 10 92.44 High High
Disease Link Frequency Relevance Heat
Apoptosis 577 99.92 Very High Very High Very High
Stomach Cancer 10 99.84 Very High Very High Very High
Cancer 690 99.80 Very High Very High Very High
Cholangiocarcinoma 3 99.68 Very High Very High Very High
Stress 94 99.38 Very High Very High Very High
Breast Cancer 168 99.06 Very High Very High Very High
Skin Cancer 43 98.68 Very High Very High Very High
Reprotox - General 1 64 98.52 Very High Very High Very High
INFLAMMATION 100 98.28 Very High Very High Very High
Glioma 26 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the physiological stress associated with muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase, presumably leading to decreased insulin-mediated glucose uptake.
Negative_regulation (impairs) of Positive_regulation (stimulation) of Akt in muscle associated with stress
1) Confidence 0.50 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.36 Pain Relevance 0.03
The presence of SV40 has been shown to be associated with higher levels of vascular endothelial growth factor (VEGF) (Cacciotti, 2002), telomerase activity (Foddis, 2002), expression of the cell cycle inhibitor p21WAF1/CIP1 (Baldi, 2002), p53 inactivation (Carbone, 2003) and activation of the phosphatidylinositol 3-kinase/AKT signaling pathway (Cacciotti, 2001; Ramos-Nino, 2005).
Negative_regulation (inactivation) of Positive_regulation (activation) of AKT
2) Confidence 0.41 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 0.72 Pain Relevance 0
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.
Negative_regulation (impairs) of Positive_regulation (stimulation) of Akt in skeletal muscle associated with cytokine
3) Confidence 0.36 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 10893341 Disease Relevance 0.58 Pain Relevance 0.19
Various PI 3-kinase inhibitors such as Wortmannin, LY294002 and dominant-negative Akt expression vector were used to fully prove the involvement of PI 3-K/Akt pathway in the regulation of NF-?
Negative_regulation (inhibitors) of Positive_regulation (vector) of Akt
4) Confidence 0.32 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.22 Pain Relevance 0
As described above, PTEN antagonizes the PI3K/AKT pathway by dephosphorylating PIP3, resulting in decreased translocation of AKT activation.
Negative_regulation (decreased) of Positive_regulation (activation) of AKT
5) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.80 Pain Relevance 0
One recent study has found that induction of the PDGF pathway in human LEC resulted in a PI3K/Akt pathway dependent increase in cellular migration [21].
Negative_regulation (resulted) of Positive_regulation (increase) of Akt
6) Confidence 0.29 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.52 Pain Relevance 0
Temsirolimus and rapamycin inhibit the downstream target of activated Akt, mTOR Complex 1 [1,15,26].
Negative_regulation (inhibit) of Positive_regulation (activated) of Akt
7) Confidence 0.28 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.68
MNTX-induced Src inactivation results in inhibition of PI3 kinase and mTOR signaling required for Akt activation (serine/threonine phosphorylation).
Negative_regulation (inhibition) of Positive_regulation (activation) of Akt
8) Confidence 0.28 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0 Pain Relevance 0.08
In addition, pharmacological blockade or knockdown of the p38 gene down-regulated Akt activation and LC3II levels but did not affect ERK, and pharmacological blockade or knockdown of the ERK gene up-regulated LC3II induction by capsaicin.
Negative_regulation (down-regulated) of Positive_regulation (activation) of Akt associated with qutenza
9) Confidence 0.25 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.58 Pain Relevance 0.80
A significant reduction in the basal levels of activation of the EGFR and of Akt was observed in HDS cells following treatment with gefitinib.
Negative_regulation (reduction) of Positive_regulation (activation) of Akt
10) Confidence 0.25 Published 2005 Journal Endocr. Relat. Cancer Section Abstract Doc Link 15947117 Disease Relevance 0.29 Pain Relevance 0.07
These findings indicate a potential role for inhibition of Akt activation in CKAP4-mediated APF antiproliferative activity.


Negative_regulation (inhibition) of Positive_regulation (activation) of Akt
11) Confidence 0.25 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3020166 Disease Relevance 0.05 Pain Relevance 0
To explore whether inhibition of Akt activation may be the mechanism responsible for induction of apoptosis in MDA-MB-231 cells, we determined the effect of celecoxib on phosphorylation of Akt on breast cancer cell lines.
Negative_regulation (inhibition) of Positive_regulation (activation) of Akt in MDA-MB-231 associated with breast cancer and apoptosis
12) Confidence 0.22 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.84 Pain Relevance 0
At the molecular level, activation of protein kinase B/Akt was significantly reduced at 60 ?
Negative_regulation (reduced) of Positive_regulation (activation) of Akt
13) Confidence 0.22 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.78 Pain Relevance 0.11
Cyclooxygenase-2 inhibitor nimesulide suppresses telomerase activity by blocking Akt/PKB activation in gastric cancer cell line.
Negative_regulation (blocking) of Positive_regulation (activation) of Akt/PKB associated with cox2 and stomach cancer
14) Confidence 0.22 Published 2004 Journal Dig. Dis. Sci. Section Title Doc Link 15309882 Disease Relevance 0.42 Pain Relevance 0.23
The PI3K pathway is negatively regulated by PTEN (phosphatase and TENsin homolog), which converts PIP3 in PIP2, preventing PKB activation and Bad phosphorylation/sequestration.
Negative_regulation (preventing) of Positive_regulation (activation) of PKB
15) Confidence 0.19 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.10 Pain Relevance 0.03
Celecoxib was recently shown to induce apoptosis of cancer cells by blocking Akt activation in rat cholangiocarcinoma and human prostate cancer cells in vitro [21,22].
Negative_regulation (blocking) of Positive_regulation (activation) of Akt associated with cholangiocarcinoma, cancer, apoptosis and reprotox - general 1
16) Confidence 0.16 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1175053 Disease Relevance 0.83 Pain Relevance 0
Previous study in breast cancer cells has also found that FRNK overexpression inhibited the activation of FAK and PKB and thus enhanced chemotherapy-induced cell apoptosis [37].
Negative_regulation (inhibited) of Positive_regulation (activation) of PKB associated with breast cancer and apoptosis
17) Confidence 0.13 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2806309 Disease Relevance 0.59 Pain Relevance 0
This combination also suppresses the activation of Akt and ERK1/2 pathways 54.
Negative_regulation (suppresses) of Positive_regulation (activation) of Akt
18) Confidence 0.12 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 0.97 Pain Relevance 0.24
AKT activation was decreased in keratinocytes cultured with the ?
Negative_regulation (decreased) of Positive_regulation (activation) of AKT in keratinocytes
19) Confidence 0.10 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621262 Disease Relevance 0 Pain Relevance 0.40
Genistein treatment can decrease activation of Akt and NF-?
Negative_regulation (decrease) of Positive_regulation (activation) of Akt
20) Confidence 0.09 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 1.60 Pain Relevance 0

General Comments

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