INT89394

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Context Info
Confidence 0.82
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 35.84
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (INS) small molecule metabolic process (INS) extracellular region (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS)
Anatomy Link Frequency
adipocytes 8
hepatocytes 4
muscle 3
liver 2
myocytes 1
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 5 100.00 Very High Very High Very High
antagonist 25 96.96 Very High Very High Very High
cytokine 383 95.92 Very High Very High Very High
Inflammation 592 95.52 Very High Very High Very High
Serotonin 9 93.32 High High
alcohol 46 92.84 High High
tolerance 103 83.28 Quite High
antidepressant 1 76.96 Quite High
Catecholamine 2 67.24 Quite High
Neurotransmitter 7 60.00 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 351 100.00 Very High Very High Very High
Fatty Liver 6 99.88 Very High Very High Very High
Obesity 769 99.60 Very High Very High Very High
Disease 296 99.60 Very High Very High Very High
Diabetes Mellitus 994 99.36 Very High Very High Very High
Alcoholic Fatty Liver 4 99.28 Very High Very High Very High
Polycystic Ovary Syndrome 166 98.08 Very High Very High Very High
Targeted Disruption 37 97.60 Very High Very High Very High
Stress 295 96.68 Very High Very High Very High
Necrosis 55 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin is a hormone secreted from the ?
Phosphorylation (hormone) of Insulin
1) Confidence 0.82 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792528 Disease Relevance 0.10 Pain Relevance 0
Biphasic insulin aspart versus NPH or glargine in type 2 diabetes
Phosphorylation (aspart) of Biphasic insulin associated with diabetes mellitus
2) Confidence 0.81 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350128 Disease Relevance 0.72 Pain Relevance 0
A unique defect in serine phosphorylation of the insulin receptor that resulted in decreased activation of the receptor has been identified in about 50% of women with PCOS (Zhang et al 1995).
Phosphorylation (phosphorylation) of insulin associated with polycystic ovary syndrome
3) Confidence 0.76 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.55 Pain Relevance 0.08
Studies suggest that insulin induced receptor autophosphorylation is markedly diminished in approximately 50% of PCOS women.
Phosphorylation (autophosphorylation) of insulin associated with polycystic ovary syndrome
4) Confidence 0.76 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994046 Disease Relevance 1.37 Pain Relevance 0
One possible link appears to be between the altered phosphorylation of the majority of the signaling molecules at 30 mU/l insulin and above and the decreased expression of MAFbx and possibly the C2 proteasome subunit.
Phosphorylation (phosphorylation) of insulin
5) Confidence 0.74 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.07 Pain Relevance 0
Insulin-stimulated insulin receptor substrate (IRS)-1 tyrosine phosphorylation was 45% lower after ECC (P<0.05).
Phosphorylation (phosphorylation) of insulin
6) Confidence 0.72 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.61 Pain Relevance 0.04
Although GH is known to impair insulin action directly by reducing phosphorylation of insulin receptor substrate-1 (IRS-1) and IRS-2 proteins [38,39], a long drug washout was used to reduce possible confounding effects of GH and IGF-1 on glucose disposal [40].
Phosphorylation (phosphorylation) of insulin
7) Confidence 0.66 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1865086 Disease Relevance 0.22 Pain Relevance 0.03
Insulin-stimulated insulin receptor substrate (IRS)-1 tyrosine phosphorylation was 45% lower after ECC (P<0.05).
Phosphorylation (phosphorylation) of Insulin
8) Confidence 0.55 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.61 Pain Relevance 0.04
Because these forkhead family members are known to be excluded from the nucleus via Akt-mediated phosphorylation downstream of insulin signaling [41], and since TXNIP induction by glucose is blunted by the activation of the phosphatidylinositol-3-kinase/Akt pathway [38], this class of transcription factors represent excellent candidate mediators of the insulin-stimulated repression of TXNIP.


Phosphorylation (phosphorylation) of insulin in nucleus associated with repression
9) Confidence 0.55 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 0.20 Pain Relevance 0.05
This results in a decrease in autophosphorylation of the insulin receptor.
Phosphorylation (autophosphorylation) of insulin
10) Confidence 0.47 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2871552 Disease Relevance 1.10 Pain Relevance 0
The mechanisms by which glucose and lipids induce insulin resistance are not entirely clear but are thought to involve increased serine phosphorylation and deactivation of the insulin receptor [7].
Phosphorylation (phosphorylation) of insulin associated with insulin resistance
11) Confidence 0.43 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1858708 Disease Relevance 1.14 Pain Relevance 0.06
We measured time-courses in primary human adipocytes for the short-term phosphorylation dynamics of the insulin receptor (IR) and the IR substrate-1 in response to a step increase in insulin concentration.
Phosphorylation (phosphorylation) of insulin in adipocytes associated with obesity
12) Confidence 0.41 Published 2008 Journal PLoS Computational Biology Section Abstract Doc Link PMC2424138 Disease Relevance 0.27 Pain Relevance 0
signaling, is extensively implicated in all aspects of skeletal muscle function [61], while at an individual gene level, the directional changes in ERK1/2 and MEK1/2 are consistent with the emerging mechanism through which saturated fatty acids induce muscle insulin resistance [62] and with decreased IRS-1 (insulin receptor substrate-1) phosphorylation [63] promoting the degradation of IRS-1 [64] and thus impaired insulin action.
Phosphorylation (phosphorylation) of insulin in muscle associated with insulin resistance
13) Confidence 0.40 Published 2010 Journal Genome Med Section Body Doc Link PMC2847700 Disease Relevance 0.77 Pain Relevance 0
In detail, insulin binding to its specific receptor leads to the autophosphorylation of the trans-membrane ?
Phosphorylation (autophosphorylation) of insulin
14) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.58 Pain Relevance 0.03
It has therefore been proposed that changes in the equilibrium between serine or tyrosine phosphorylation lead to pathological conditions of insulin resistance and diabetes.
Phosphorylation (phosphorylation) of insulin associated with diabetes mellitus and insulin resistance
15) Confidence 0.29 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.85 Pain Relevance 0.12
Further on, the authors investigated the intracellular signaling of visfatin and suggested it to tyrosine-phosphorylate the insulin receptor in hepatocytes, myocytes, and adipocytes.
Phosphorylation (phosphorylate) of insulin in adipocytes associated with obesity
16) Confidence 0.21 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 0.60 Pain Relevance 0
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Phosphorylation (phosphorylation) of insulin in hepatocytes associated with obesity
17) Confidence 0.21 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.96 Pain Relevance 0.21
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Phosphorylation (phosphorylation) of insulin in hepatocytes associated with obesity
18) Confidence 0.21 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.98 Pain Relevance 0.16
in adipocytes and hepatocytes, which can then increase the serine phosphorylation of insulin receptor substrate1 (IRS-1), with subsequent reduction in insulin-dependent tyrosine phosphorylation of IRS-1, and ultimately glucose transport [98].
Phosphorylation (phosphorylation) of insulin in hepatocytes associated with obesity
19) Confidence 0.21 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 0.98 Pain Relevance 0.16
causes an inhibition of auto-phosphorylation of tyrosine residues of the insulin receptor (IR) and an induction of serine phosphorylation of insulin receptor substrate-1, which in turn causes serine phosphorylation of the IR in adipocytes and inhibits tyrosine phosphorylation [74].
Phosphorylation (phosphorylation) of insulin in adipocytes associated with obesity
20) Confidence 0.21 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.44 Pain Relevance 0.26

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