INT89396

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Context Info
Confidence 0.82
First Reported 2000
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 225
Total Number 233
Disease Relevance 111.66
Pain Relevance 19.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
AsPC-1 5
endothelial cell 4
T24 3
muscle 3
HT-1080 3
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 218 100.00 Very High Very High Very High
cINOD 392 99.96 Very High Very High Very High
Nicotine 554 99.80 Very High Very High Very High
chemokine 108 99.68 Very High Very High Very High
aspirin 100 99.68 Very High Very High Very High
methotrexate 72 99.28 Very High Very High Very High
imagery 156 99.04 Very High Very High Very High
Morphine 45 99.00 Very High Very High Very High
Inflammation 902 98.92 Very High Very High Very High
COX-2 inhibitor 510 98.50 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 4259 100.00 Very High Very High Very High
Cancer 4027 100.00 Very High Very High Very High
Stress 358 99.96 Very High Very High Very High
INFLAMMATION 1079 99.86 Very High Very High Very High
Breast Cancer 845 99.84 Very High Very High Very High
Hypoxia 336 99.72 Very High Very High Very High
Pancreatic Cancer 747 99.60 Very High Very High Very High
Tuberous Sclerosis 2 99.44 Very High Very High Very High
Endometrial Cancer 557 99.36 Very High Very High Very High
Hyperglycemia 102 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac and its metabolites down-regulated Akt phosphorylation, inhibited MMP-2 production, and significantly inhibited invasiveness of human glioblastoma cells.
Phosphorylation (phosphorylation) of Akt associated with glioblastoma
1) Confidence 0.82 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.66 Pain Relevance 0.20
Furthermore, only celecoxib showed Akt phosphorylation reduction and an anti-invasivness in glioblastoma cells, whereas aspirin, ketoprofen, ketorolac, and naproxen did not.
Phosphorylation (phosphorylation) of Akt associated with aspirin, glioblastoma and acular
2) Confidence 0.82 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.65 Pain Relevance 0.23
Immunohistochemical staining using an anti-phosphorylated-AKT antibody showed that phosphorylated (activated) AKT was expressed in cancer cells but not in neighboring normal mucosa in 16 cases (84.2%).
Phosphorylation (phosphorylated) of AKT associated with cancer
3) Confidence 0.82 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15150102 Disease Relevance 1.00 Pain Relevance 0.14
This effect was correlated with inhibition of the phosphorylation of the PDK1 downstream substrate Akt/protein kinase B (PKB) on two regulatory sites, Thr(308) and Ser(473).
Phosphorylation (phosphorylation) of Akt
4) Confidence 0.80 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.83 Pain Relevance 0.08
These include recent insights into inhibiting cell proliferation by interfering with mitotic spindle microtubule function, decrease Matrix Metalloproteinase (MMP) activity, block the cell cycle in the S or G2/M phases to interfere with processes of cell division, suppress O2(-) generation in leukocytes, inhibit different protein kinases, modulate the signalings, induce carcinogen-detoxifying enzymes glutathione S-transferases (GSTs) and/or NAD(P)H quinine oxidoreductase (NQO1), suppress the phosphorylation of Akt/PKB as a mechanism inhibiting inflammation, progress in structure modification to increase in anti-fungal action, to broaden against bacteria spectrum, to enhance inhibiting activities of nitric oxide synthase (NOS) and cyclooxygenase (COX), to strengthen anti-oxidant activity and to exhibite a much higher cytotoxicity against human umbilical vein endothelial cell (HUVEC).
Phosphorylation (phosphorylation) of PKB in endothelial cell associated with inflammation and metalloproteinase
5) Confidence 0.80 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754420 Disease Relevance 0.50 Pain Relevance 0.23
Treatment of human aortic endothelial cells with recombinant hepatocyte growth factor resulted in a significant increase in cell proliferation, accompanied by mitogen-activated protein kinase and Akt/protein kinase B phosphorylation.
Phosphorylation (phosphorylation) of Akt in endothelial cells
6) Confidence 0.80 Published 2005 Journal Expert Rev Cardiovasc Ther Section Abstract Doc Link 15889978 Disease Relevance 0.18 Pain Relevance 0
We found that the levels of constitutive phosphorylation of Akt/PKB on serine 473 correlate with the sensitivity of the three cell lines to naltrindole treatment.
Phosphorylation (phosphorylation) of Akt
7) Confidence 0.80 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.83 Pain Relevance 0.13
Furthermore, naltrindole treatment not only reduced the phosphorylation of the Akt/PKB upstream kinase phosphoinositide-dependent kinase-1, but also its downstream effectors glycogen synthase kinase-3beta and the Forkhead transcription factors AFX and FKHR.
Phosphorylation (phosphorylation) of Akt
8) Confidence 0.80 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.89 Pain Relevance 0.12
Naltrindole treatment reduced constitutive phosphorylation of Akt/PKB on serine 473 and threonine 308 in cells.
Phosphorylation (phosphorylation) of Akt
9) Confidence 0.80 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.75 Pain Relevance 0.14
This effect was correlated with inhibition of the phosphorylation of the PDK-1 downstream substrate Akt/protein kinase B (PKB).
Phosphorylation (phosphorylation) of Akt
10) Confidence 0.80 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15965068 Disease Relevance 0.14 Pain Relevance 0.06
Both CAP and WIN induced transient increases in Erk1/2, p38, JNK1/2 MAPK and Akt/PI-3K phosphorylation status resulting in cell proliferation and migration increases which mirrored those elicited by EGF.
Phosphorylation (phosphorylation) of Akt
11) Confidence 0.80 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.14 Pain Relevance 0.62
Complete inhibition of interleukin (IL)-1beta-induced Akt phosphorylation occurred at 50 microM LY29 or 100 nM WM.
Phosphorylation (phosphorylation) of Akt
12) Confidence 0.80 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.06
These include recent insights into inhibiting cell proliferation by interfering with mitotic spindle microtubule function, decrease Matrix Metalloproteinase (MMP) activity, block the cell cycle in the S or G2/M phases to interfere with processes of cell division, suppress O2(-) generation in leukocytes, inhibit different protein kinases, modulate the signalings, induce carcinogen-detoxifying enzymes glutathione S-transferases (GSTs) and/or NAD(P)H quinine oxidoreductase (NQO1), suppress the phosphorylation of Akt/PKB as a mechanism inhibiting inflammation, progress in structure modification to increase in anti-fungal action, to broaden against bacteria spectrum, to enhance inhibiting activities of nitric oxide synthase (NOS) and cyclooxygenase (COX), to strengthen anti-oxidant activity and to exhibite a much higher cytotoxicity against human umbilical vein endothelial cell (HUVEC).
Phosphorylation (phosphorylation) of Akt in endothelial cell associated with inflammation and metalloproteinase
13) Confidence 0.80 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754420 Disease Relevance 0.50 Pain Relevance 0.23
These targets include the activation of apoptosis; suppression of growth factor expression or signalling; downregulation of antiapoptotic proteins; suppression of phosphatidylinositol-3'-kinase/Akt, NF-kappaB, Janus kinase-signal transducer and activator of transcription and activator protein-1 signalling pathways; and downregulation of angiogenesis through inhibition of vascular endothelial growth factor expression, cyclooxygenase-2, matrix metalloproteinase-9, urokinase-type plasminogen activator, adhesion molecules and cyclin D1.
Phosphorylation (suppression) of Akt associated with metalloproteinase, apoptosis and adhesions
14) Confidence 0.79 Published 2004 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15461561 Disease Relevance 0.77 Pain Relevance 0.10
Naltrindole treatment reduced constitutive phosphorylation of Akt/PKB on serine 473 and threonine 308 in cells.
Phosphorylation (phosphorylation) of Akt
15) Confidence 0.79 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.75 Pain Relevance 0.14
Evidence of overactivation of the PI3K-Akt-mTOR pathway manifesting as phosphorylation of downstream proteins appeared to correlate inversely with survival, although numbers were small and this finding requires confirmation [28].
Phosphorylation (phosphorylation) of Akt
16) Confidence 0.79 Published 2010 Journal Curr Neurol Neurosci Rep Section Body Doc Link PMC2857752 Disease Relevance 0.99 Pain Relevance 0
The phosphorylation of a conserved threonine residue (Thr308 in Akt1, Thr309 in Akt2 and Thr305 in Akt3), upon growth factor stimulation, is required for Akt activation, while the phosphorylation of a serine residue (Ser473 in Akt1, Ser474 in Akt2 and Ser474 in Akt3) is only required for maximal Akt activity [21,24-26].
Phosphorylation (phosphorylation) of Akt1
17) Confidence 0.75 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.42 Pain Relevance 0.04
In both 87MG and PC3 cells, treatment with HDAC inhibitors decreases the levels of Akt phosphorylation [49].
Phosphorylation (phosphorylation) of Akt
18) Confidence 0.75 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.65 Pain Relevance 0
The link between the action of HDAC inhibitors and the down-regulation of Akt phosphorylation has been reported previously [18,49,50].
Phosphorylation (phosphorylation) of Akt
19) Confidence 0.75 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.70 Pain Relevance 0
Cyclic AMP, an inducer of Akt phosphorylation, suppresses Akt inactivation, Bid cleavage, and DNA fragmentation.
Phosphorylation (phosphorylation) of Akt in cleavage
20) Confidence 0.75 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.54 Pain Relevance 0.39

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