INT89397

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Context Info
Confidence 0.67
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 16.98
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
skeletal muscle 3
neuronal 2
muscle 1
cleavage 1
brain 1
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 60 99.40 Very High Very High Very High
Pain 20 99.40 Very High Very High Very High
endometriosis 216 99.36 Very High Very High Very High
ischemia 32 99.32 Very High Very High Very High
metalloproteinase 169 98.88 Very High Very High Very High
antagonist 53 97.94 Very High Very High Very High
Opioid 6 97.72 Very High Very High Very High
chemokine 501 96.08 Very High Very High Very High
corticosteroid 8 91.36 High High
cINOD 1 89.76 High High
Disease Link Frequency Relevance Heat
Breast Cancer 102 99.80 Very High Very High Very High
Apoptosis 124 99.72 Very High Very High Very High
Fibrosarcoma 5 99.48 Very High Very High Very High
Carcinoma 200 99.46 Very High Very High Very High
Endometriosis 276 99.36 Very High Very High Very High
Cv General 4 Under Development 4 99.32 Very High Very High Very High
Cancer 1168 99.20 Very High Very High Very High
Ovarian Cancer 455 99.12 Very High Very High Very High
Stress 9 99.06 Very High Very High Very High
Malignant Neoplastic Disease 125 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, the physiological stress associated with muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase, presumably leading to decreased insulin-mediated glucose uptake.
Positive_regulation (stimulation) of PI 3-kinase in muscle associated with stress
1) Confidence 0.67 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.36 Pain Relevance 0.03
This observation is in accordance with a previous report indicating that in a cerebral ischemia model of the BBB disruption, the increased PI3kinase/Akt signaling promotes neuronal survival [22].
Positive_regulation (increased) of PI3kinase in neuronal associated with cv general 4 under development and ischemia
2) Confidence 0.67 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.33 Pain Relevance 0.11
as well as activation of PI3-kinase and ERK 1/2, promoting the concept that these
Positive_regulation (activation) of PI3-kinase
3) Confidence 0.67 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.45 Pain Relevance 0.03
subsequent downstream activation of PI3-kinase ?.
Positive_regulation (activation) of PI3-kinase
4) Confidence 0.67 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.45 Pain Relevance 0.04
Although we have not assessed the effect on the activation of PI 3-kinase, it was previously described that PI 3-kinase activation closely correlates with IRS-1 phosphorylation in skeletal muscle of STZ-diabetes (46).
Positive_regulation (activation) of PI 3-kinase in skeletal muscle associated with diabetes mellitus
5) Confidence 0.67 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.44 Pain Relevance 0
Although we have not assessed the effect on the activation of PI 3-kinase, it was previously described that PI 3-kinase activation closely correlates with IRS-1 phosphorylation in skeletal muscle of STZ-diabetes (46).
Positive_regulation (activation) of PI 3-kinase in skeletal muscle associated with diabetes mellitus
6) Confidence 0.67 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.38 Pain Relevance 0
The activation of PI 3-kinase is required for insulin to stimulate glucose transport (44,45).
Positive_regulation (activation) of PI 3-kinase
7) Confidence 0.67 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.45 Pain Relevance 0
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.
Positive_regulation (stimulation) of PI 3-kinase in skeletal muscle associated with cytokine
8) Confidence 0.67 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 10893341 Disease Relevance 0.58 Pain Relevance 0.19
Some investigators have claimed that PIK3CA mutations are mutually exclusive of PTEN mutations, suggesting that tumorigenic signaling through this pathway can occur either through activation of PIK3CA or inactivation of PTEN [9].
Positive_regulation (activation) of PIK3CA
9) Confidence 0.56 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.52 Pain Relevance 0
The present data revealed that insulin + GJG treatment inhibits the increased IRS-1 tyrosine phosphorylation levels (Fig. 5B); therefore, these improvements are thought to improve the abnormal activation of PI 3-kinase (8,9) resulting in the correction of decreased efficiency of glucose metabolization.
Positive_regulation (activation) of PI 3-kinase
10) Confidence 0.49 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538504 Disease Relevance 0.29 Pain Relevance 0
Application of ultrasound results in activation of PI3kinase/Akt signaling pathway in neuronal cells.


Positive_regulation (activation) of PI3kinase in neuronal
11) Confidence 0.45 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.22 Pain Relevance 0.06
Obese individuals who have recently lost substantial amounts of weight became insulinresistant when put on a short-term hypercaloric diet, while lean individuals remained sensitive to insulin under identical circumstances.50 This phenomenon is explained, at least to some extent, by the ability of nutrient excess to block the activation of IRS/ PI 3-kinase signal transduction.51 Indeed, blunting of signal transduction by macronutrients has been observed in peripheral tissues as well as in brain tissue.29,52,53 Lastly, cumulating data have indicated that free fatty acids (FFAs) and glucose are each capable of increasing hepatic sensitivity to insulin and of reducing hepatic glucose production.
Positive_regulation (activation) of PI 3-kinase in brain associated with obesity
12) Confidence 0.45 Published 2007 Journal Obes Surg Section Body Doc Link PMC2798024 Disease Relevance 0.46 Pain Relevance 0.07
These results indicate a role for PI3K activation in the signalling of both AA and PMA to produce MMP-9.
Positive_regulation (activation) of PI3K
13) Confidence 0.44 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
Activation of PI3K leads to phosphorylation of inositol lipids, in response to activation and membrane translocation of Akt/Protein kinase B.
Positive_regulation (Activation) of PI3K
14) Confidence 0.44 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.10 Pain Relevance 0
SHC1 could therefore contribute the activation of MAPK and/or the activation of the PI3K-Akt pathway in these tumors.
Positive_regulation (activation) of PI3K associated with cancer
15) Confidence 0.39 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2615013 Disease Relevance 1.03 Pain Relevance 0.33
Recently, interactions between the PI3K/AKT and p53 signaling pathways have been described in which activation of the PI3K/AKT pathway through PTEN or PIK3CA mutations, together with p53 inactivation, results in malignant transformation [15].
Positive_regulation (activation) of PIK3CA associated with malignant neoplastic disease
16) Confidence 0.38 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.66 Pain Relevance 0
The tumors carrying exon 9 PIK3CA mutations are more likely to be low-grade carcinomas; in contrast, carcinomas with exon 20 mutations or PIK3CA mRNA overexpression are often high-grade carcinomas associated with myometrial invasion and tended to have lymphovascular invasion [15].
Positive_regulation (overexpression) of PIK3CA associated with cancer and carcinoma
17) Confidence 0.38 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.11 Pain Relevance 0
It was shown that in leukemia cells, several growth and survival factors from the tumor microenvironment, including CXCR4 activation, induce PI3K activation.
Positive_regulation (activation) of PI3K associated with leukemia and cancer
18) Confidence 0.32 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.37 Pain Relevance 0
Indeed, when we blocked the capability of PI3K to generate PIP3 in MonoMac 6 cells by Ly 294002 (a specific inhibitor of PI3K), MMP-9 production was inhibited in both AA and PMA stimulated cells.
Positive_regulation (capability) of PI3K
19) Confidence 0.31 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.06 Pain Relevance 0
MMP-9 production in response to LPS-induced PI3K stimulation has also been reported to occur through IKK?
Positive_regulation (stimulation) of PI3K
20) Confidence 0.31 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.30 Pain Relevance 0.07

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