INT89399

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
muscle 2
skeletal muscle 2
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 6 99.72 Very High Very High Very High
Pain 2 99.72 Very High Very High Very High
metalloproteinase 3 50.00 Quite Low
Inflammation 15 47.12 Quite Low
COX2 1 45.72 Quite Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 4 99.38 Very High Very High Very High
Insulin Resistance 8 95.44 Very High Very High Very High
Necrosis 2 73.00 Quite High
Cancer 2 72.64 Quite High
Fibrosarcoma 1 64.96 Quite High
INFLAMMATION 17 47.12 Quite Low
Rupture 4 5.00 Very Low Very Low Very Low
Atherosclerotic Plaque 3 5.00 Very Low Very Low Very Low
Atherosclerosis 2 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.
Negative_regulation (impairs) of Positive_regulation (stimulation) of PI 3-kinase in skeletal muscle associated with cytokine
1) Confidence 0.57 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 10893341 Disease Relevance 0.58 Pain Relevance 0.19
In summary, the physiological stress associated with muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase, presumably leading to decreased insulin-mediated glucose uptake.
Negative_regulation (impairs) of Positive_regulation (stimulation) of PI 3-kinase in muscle associated with stress
2) Confidence 0.41 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.36 Pain Relevance 0.03
Indeed, when we blocked the capability of PI3K to generate PIP3 in MonoMac 6 cells by Ly 294002 (a specific inhibitor of PI3K), MMP-9 production was inhibited in both AA and PMA stimulated cells.
Negative_regulation (blocked) of Positive_regulation (capability) of PI3K
3) Confidence 0.27 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.06 Pain Relevance 0

General Comments

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