INT894

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Context Info
Confidence 0.48
First Reported 1979
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 84
Total Number 87
Disease Relevance 29.16
Pain Relevance 29.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 4
mammary gland 4
smooth muscle 3
platelet 3
hypothalamus 3
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 79 100.00 Very High Very High Very High
Pain 42 100.00 Very High Very High Very High
Opioid 39 100.00 Very High Very High Very High
visual analogue scale 34 100.00 Very High Very High Very High
Enkephalin 34 100.00 Very High Very High Very High
Spinal cord 25 100.00 Very High Very High Very High
Neuropeptide 21 100.00 Very High Very High Very High
Cholecystokinin 14 100.00 Very High Very High Very High
opiate 14 100.00 Very High Very High Very High
antagonist 216 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 41 100.00 Very High Very High Very High
INFLAMMATION 77 99.92 Very High Very High Very High
Eating Disorder 17 99.92 Very High Very High Very High
Cv Unclassified Under Development 9 99.76 Very High Very High Very High
Urological Neuroanatomy 30 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 140 99.70 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

5 99.68 Very High Very High Very High
Headache 79 99.66 Very High Very High Very High
Hyponatremia 83 99.48 Very High Very High Very High
Cv General 3 Under Development 18 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interactions between vasopressin and mu-opioid systems in the rat fetus.
vasopressin Binding (Interactions) of associated with opioid
1) Confidence 0.48 Published 1996 Journal Physiol. Behav. Section Title Doc Link 8804667 Disease Relevance 0 Pain Relevance 0.43
The communication was designed to investigate the interaction between AVP and NA in the rat PVN during the pain process.
AVP Binding (interaction) of in PVN associated with pain
2) Confidence 0.48 Published 2009 Journal Neuropeptides Section Abstract Doc Link 19573913 Disease Relevance 0.49 Pain Relevance 0.59
The aim of the present study was to determine the role of the interaction between vasopressin and sympathetic system in the development of this hypertension by using AVP V1 antagonist and alpha blocker phentolamine under anesthesia condition.
vasopressin Binding (interaction) of in sympathetic associated with anesthesia, antagonist and hypertension
3) Confidence 0.48 Published 2000 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 10789696 Disease Relevance 0.46 Pain Relevance 0.17
In view of the presence of AVP receptors in mammary tissue, these findings suggested that the iodinated antagonist binds to AVP receptors.
AVP Binding (binds) of associated with antagonist
4) Confidence 0.47 Published 1989 Journal Biochem. Cell Biol. Section Abstract Doc Link 2546575 Disease Relevance 0.07 Pain Relevance 0.41
Interaction of arginine vasopressin and corticotropin releasing factor demonstrated with an improved bioassay.
arginine vasopressin Binding (Interaction) of
5) Confidence 0.47 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Title Doc Link 3873659 Disease Relevance 0.08 Pain Relevance 0.18
TREATMENT: The AVP-receptor antagonists, a new class of agents, correct hyponatremia by directly blocking the binding of AVP with its receptors.
AVP Binding (binding) of associated with hyponatremia and antagonist
6) Confidence 0.45 Published 2007 Journal Support Care Cancer Section Abstract Doc Link 17701059 Disease Relevance 1.54 Pain Relevance 0.13
Anorexia nervosa is associated with vasopressin, oxytocin and serotonin abnormalities.
vasopressin Binding (associated) of associated with congenital anomalies, serotonin and eating disorder
7) Confidence 0.44 Published 1993 Journal Brain Res. Section Abstract Doc Link 8101130 Disease Relevance 0.65 Pain Relevance 0.30
Using this assay, we studied CRF-arginine vasopressin (AVP) interactions at doses that were expected to raise systemic peptide concentrations to levels measured in hypophysial portal blood.
AVP Binding (interactions) of in blood
8) Confidence 0.41 Published 1985 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 3873659 Disease Relevance 0.09 Pain Relevance 0.17
We now explore the mechanisms of vasoconstriction and vasodilation of the vascular smooth muscle, with an emphasis on vasopressin interaction in these pathways.
vasopressin Binding (interaction) of in smooth muscle associated with increased venous pressure under development
9) Confidence 0.40 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.69 Pain Relevance 0.07
Vascular smooth muscle contraction pathways and vasopressin interaction
vasopressin Binding (interaction) of in smooth muscle
10) Confidence 0.40 Published 2004 Journal Crit Care Section Body Doc Link PMC420051 Disease Relevance 0.54 Pain Relevance 0.10
These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH.
AVP Binding (interaction) of
11) Confidence 0.38 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9151749 Disease Relevance 0.75 Pain Relevance 0.26
The present studies examine the neuroanatomical and neurochemical interaction between AVP and 5-HT at the level of the anterior hypothalamus (AH) in the control of offensive aggression in Syrian golden hamsters.
AVP Spec (examine) Binding (interaction) of in hypothalamus associated with aggression
12) Confidence 0.38 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9151749 Disease Relevance 0.44 Pain Relevance 0.12
Interaction of corticotropin-releasing factor and arginine vasopressin on adrenocorticotropin secretion in vivo.
vasopressin Binding (Interaction) of
13) Confidence 0.38 Published 1983 Journal Endocrinology Section Title Doc Link 6307672 Disease Relevance 0 Pain Relevance 0.09
These findings indicate that AVP has significant vascular effects in the rat spinal cord that are associated with ischemia and neurological dysfunction.
AVP Binding (associated) of in spinal cord associated with anesthesia, ischemia and spinal cord
14) Confidence 0.37 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2524587 Disease Relevance 0.27 Pain Relevance 0.36
Pituicytes in culture respond to vasopressin with a mobilization of calcium from intracellular stores.
vasopressin Binding (respond) of in Pituicytes
15) Confidence 0.37 Published 1993 Journal J. Neuroendocrinol. Section Abstract Doc Link 8680428 Disease Relevance 0 Pain Relevance 0.45
The effects of acute and chronic ketocyclazocine (KCZ, a kappa receptor agonist) and its interactions with oxytocin (OXY) or vasopressin (AVP) were investigated on food intake in free-fed rats.
AVP Binding (interactions) of associated with agonist
16) Confidence 0.37 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1311456 Disease Relevance 0.14 Pain Relevance 0.09
The effects of acute and chronic ketocyclazocine (KCZ, a kappa receptor agonist) and its interactions with oxytocin (OXY) or vasopressin (AVP) were investigated on food intake in free-fed rats.
vasopressin Binding (interactions) of associated with agonist
17) Confidence 0.37 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1311456 Disease Relevance 0.14 Pain Relevance 0.09
Vasopressin and its carrier protein, vasopressin-associated neurophysin, are co-packaged together with an opioid peptide, dynorphin, into 160 nm diameter neurosecretory vesicles in the normal rat hypothalamo-neurohypophysial system.
Vasopressin Binding (co-packaged) of in vesicles associated with dynorphin and opioid
18) Confidence 0.37 Published 1985 Journal Peptides Section Abstract Doc Link 2863811 Disease Relevance 0 Pain Relevance 0.29
The concentration of oxytocin receptors in mammary gland, as determined by [125I]d(CH2)5(1)[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT binding, was 4 times greater than the concentration of high-affinity AVP receptors, as determined by [3H]AVP binding.
AVP Binding (binding) of in mammary gland
19) Confidence 0.37 Published 1989 Journal Biochem. Cell Biol. Section Abstract Doc Link 2546575 Disease Relevance 0.06 Pain Relevance 0.33
These values were comparable with those found for AVP receptors of kidney plasma membranes.
AVP Binding (found) of in plasma
20) Confidence 0.37 Published 1989 Journal Biochem. Cell Biol. Section Abstract Doc Link 2546575 Disease Relevance 0.08 Pain Relevance 0.32

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