INT89401

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Context Info
Confidence 0.58
First Reported 2000
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 68
Total Number 70
Disease Relevance 35.61
Pain Relevance 2.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (AKT1) nucleoplasm (AKT1) transport (AKT1)
small molecule metabolic process (AKT1) enzyme binding (AKT1) carbohydrate metabolic process (AKT1)
Anatomy Link Frequency
MDA-MB-468 4
MECs 4
SiHa 2
RL95-2 2
T24 2
AKT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 79 99.80 Very High Very High Very High
imagery 22 99.26 Very High Very High Very High
cINOD 105 98.84 Very High Very High Very High
Inflammation 224 98.76 Very High Very High Very High
COX-2 inhibitor 127 98.74 Very High Very High Very High
aspirin 21 97.76 Very High Very High Very High
acular 2 96.92 Very High Very High Very High
Leflunomide 15 96.64 Very High Very High Very High
antagonist 55 94.36 High High
methotrexate 15 94.24 High High
Disease Link Frequency Relevance Heat
Endometrial Cancer 226 99.64 Very High Very High Very High
Hyperglycemia 81 99.50 Very High Very High Very High
Prostate Cancer 41 99.32 Very High Very High Very High
Apoptosis 1602 99.28 Very High Very High Very High
Glioblastoma 17 98.88 Very High Very High Very High
INFLAMMATION 276 98.76 Very High Very High Very High
Cancer 1295 98.62 Very High Very High Very High
Pancreatic Cancer 345 98.12 Very High Very High Very High
Hypoxia 39 98.00 Very High Very High Very High
Benign Prostatic Hypertrophy 1 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac and its metabolites down-regulated Akt phosphorylation, inhibited MMP-2 production, and significantly inhibited invasiveness of human glioblastoma cells.
Negative_regulation (down-regulated) of Phosphorylation (phosphorylation) of Akt associated with glioblastoma
1) Confidence 0.58 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.66 Pain Relevance 0.20
This effect was correlated with inhibition of the phosphorylation of the PDK-1 downstream substrate Akt/protein kinase B (PKB).
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of Akt
2) Confidence 0.57 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15965068 Disease Relevance 0.14 Pain Relevance 0.06
This effect was correlated with inhibition of the phosphorylation of the PDK1 downstream substrate Akt/protein kinase B (PKB) on two regulatory sites, Thr(308) and Ser(473).
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of Akt
3) Confidence 0.57 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12000750 Disease Relevance 0.83 Pain Relevance 0.08
In both 87MG and PC3 cells, treatment with HDAC inhibitors decreases the levels of Akt phosphorylation [49].
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of Akt
4) Confidence 0.54 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.65 Pain Relevance 0
Insulin-stimulated phosphatidylinositol (PI) 3-kinase, Akt (protein kinase B) serine phosphorylation, and Akt activity were reduced 34, 65, and 20%, respectively, after ECC (P < 0.05).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt
5) Confidence 0.50 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.58 Pain Relevance 0.04
In addition, the phosphorylation status of Akt in the SiHa cells was not reduced by the treatments (Fig. 5B).
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt in SiHa
6) Confidence 0.47 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.29 Pain Relevance 0
Furthermore, only celecoxib showed Akt phosphorylation reduction and an anti-invasivness in glioblastoma cells, whereas aspirin, ketoprofen, ketorolac, and naproxen did not.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Akt associated with aspirin, glioblastoma and acular
7) Confidence 0.43 Published 2005 Journal J. Cell. Biochem. Section Abstract Doc Link 15546138 Disease Relevance 0.65 Pain Relevance 0.23
These include recent insights into inhibiting cell proliferation by interfering with mitotic spindle microtubule function, decrease Matrix Metalloproteinase (MMP) activity, block the cell cycle in the S or G2/M phases to interfere with processes of cell division, suppress O2(-) generation in leukocytes, inhibit different protein kinases, modulate the signalings, induce carcinogen-detoxifying enzymes glutathione S-transferases (GSTs) and/or NAD(P)H quinine oxidoreductase (NQO1), suppress the phosphorylation of Akt/PKB as a mechanism inhibiting inflammation, progress in structure modification to increase in anti-fungal action, to broaden against bacteria spectrum, to enhance inhibiting activities of nitric oxide synthase (NOS) and cyclooxygenase (COX), to strengthen anti-oxidant activity and to exhibite a much higher cytotoxicity against human umbilical vein endothelial cell (HUVEC).
Negative_regulation (suppress) of Phosphorylation (phosphorylation) of Akt in endothelial cell associated with inflammation and metalloproteinase
8) Confidence 0.42 Published 2009 Journal Curr. Med. Chem. Section Abstract Doc Link 19754420 Disease Relevance 0.50 Pain Relevance 0.23
Complete inhibition of interleukin (IL)-1beta-induced Akt phosphorylation occurred at 50 microM LY29 or 100 nM WM.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of Akt
9) Confidence 0.41 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.06
Naltrindole treatment reduced constitutive phosphorylation of Akt/PKB on serine 473 and threonine 308 in cells.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt
10) Confidence 0.41 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.76 Pain Relevance 0.14
Furthermore, naltrindole treatment not only reduced the phosphorylation of the Akt/PKB upstream kinase phosphoinositide-dependent kinase-1, but also its downstream effectors glycogen synthase kinase-3beta and the Forkhead transcription factors AFX and FKHR.
Negative_regulation (reduced) of Phosphorylation (phosphorylation) of Akt
11) Confidence 0.41 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15574783 Disease Relevance 0.89 Pain Relevance 0.12
Western blot analysis using an antibody specific for phosphorylated Ser473 residue in Akt demonstrated that the phosphorylation level of Akt protein started to decline after 16 hours of butyrate treatment, and again valproic acid had a weaker effect (Fig. 2A).
Negative_regulation (decline) of Phosphorylation (phosphorylation) of Akt
12) Confidence 0.40 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.11 Pain Relevance 0
The link between the action of HDAC inhibitors and the down-regulation of Akt phosphorylation has been reported previously [18,49,50].
Negative_regulation (down) of Phosphorylation (phosphorylation) of Akt
13) Confidence 0.40 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.70 Pain Relevance 0
The link between the action of HDAC inhibitors and the down-regulation of Akt phosphorylation has been reported previously [18,49,50].
Negative_regulation (regulation) of Phosphorylation (phosphorylation) of Akt
14) Confidence 0.40 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.70 Pain Relevance 0
The link between the action of HDAC inhibitors and the down-regulation of Akt phosphorylation has been reported previously [18,49,50].
Negative_regulation (-) of Phosphorylation (phosphorylation) of Akt
15) Confidence 0.40 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.70 Pain Relevance 0
Whereas, phosphorylation of Akt was absent in one wild-type PTEN cell line (HEC 1-A).
Negative_regulation (absent) of Neg (absent) Phosphorylation (phosphorylation) of Akt
16) Confidence 0.37 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.24 Pain Relevance 0.03
We have showed previously that COX-2 inhibition with NS-398 in RL 95-2 and Ishikawa cells results in the inhibition of Akt phosphorylation and induction of apoptosis suggesting that the Akt/NF-?
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of Akt associated with apoptosis
17) Confidence 0.37 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.85 Pain Relevance 0.04
Thus, the presence of a wild-type PTEN protein results in the reduction of Akt activity/phosphorylation leading to the inhibition of I?
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Akt
18) Confidence 0.37 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.29 Pain Relevance 0
PI 3-K inhibition in RL 95-2 and Ishikawa cells directly blocked Akt phosphorylation and caused a reduction of COX-2 mRNA and protein [42].
Negative_regulation (blocked) of Phosphorylation (phosphorylation) of Akt
19) Confidence 0.36 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.46 Pain Relevance 0
We have showed previously that Akt inhibition in mutated PTEN endometrial cancer cells results in inhibition of Akt phosphorylation, downregulation of COX-2 gene and protein expression and stimulation of apoptosis [42].
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of Akt associated with apoptosis and endometrial cancer
20) Confidence 0.36 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.85 Pain Relevance 0

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