INT89403

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Context Info
Confidence 0.57
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 11.74
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
monocyte 1
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 22 87.24 High High
antagonist 2 81.96 Quite High
Opioid 3 81.52 Quite High
cytokine 23 70.52 Quite High
palliative 16 60.76 Quite High
Inflammation 63 60.48 Quite High
Kinase C 4 55.16 Quite High
metalloproteinase 9 50.00 Quite Low
COX2 3 42.04 Quite Low
Pain 4 41.72 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 962 99.88 Very High Very High Very High
Carcinoma 752 99.68 Very High Very High Very High
Stress 4 95.76 Very High Very High Very High
Cancer 210 95.32 Very High Very High Very High
Hepatocellular Cancer 72 95.12 Very High Very High Very High
Wound Healing 13 93.24 High High
Endometrial Cancer 40 88.56 High High
Cv Unclassified Under Development 21 87.24 High High
Death 73 85.28 High High
Insulin Resistance 26 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF-alpha production was positively correlated with reduced insulin action on PI 3-kinase (r = 0.77, P = 0.04).
Negative_regulation (reduced) of PI 3-kinase
1) Confidence 0.57 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.43 Pain Relevance 0.04
Similarly, inhibition of PI3-kinase and MAP-kinase reduced
Negative_regulation (inhibition) of PI3-kinase
2) Confidence 0.57 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2288642 Disease Relevance 0.47 Pain Relevance 0.03
Since only the heterodimer is responsible for PI 3-kinase activity, increases or decreases in p85 expression could lead to increased or decreased PI 3-kinase activity in an inverse manner [46-49].
Negative_regulation (decreased) of PI 3-kinase
3) Confidence 0.42 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.20 Pain Relevance 0
This activation is important for monocyte survival and therefore the results using PI3K or Akt inhibitors should be considered very carefully.
Negative_regulation (inhibitors) of PI3K in monocyte
4) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.22 Pain Relevance 0.03
Indeed, when we blocked the capability of PI3K to generate PIP3 in MonoMac 6 cells by Ly 294002 (a specific inhibitor of PI3K), MMP-9 production was inhibited in both AA and PMA stimulated cells.
Negative_regulation (inhibitor) of PI3K
5) Confidence 0.37 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0.07 Pain Relevance 0
For this end we incubated MonoMac 6 cells with LY 294002, an inhibitor of PI3K for 30 min before adding 10 ?
Negative_regulation (inhibitor) of PI3K
6) Confidence 0.32 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2667508 Disease Relevance 0 Pain Relevance 0
Inhibition of PI3 kinase in Huh7 cells by LY294002 alone induced apoptosis only to a minor extent (Fig. 4).
Negative_regulation (Inhibition) of PI3 kinase associated with apoptosis
7) Confidence 0.32 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.79 Pain Relevance 0
Downregulation of Mcl-1 significantly enhanced apoptosis induced by PI3K inhibition.
Negative_regulation (inhibition) of PI3K associated with apoptosis
8) Confidence 0.32 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.25 Pain Relevance 0
Inhibition of the kinase PI3K significantly increased apoptosis induction by chemotherapy.
Negative_regulation (Inhibition) of PI3K associated with apoptosis
9) Confidence 0.23 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1601962 Disease Relevance 1.75 Pain Relevance 0
Enhanced apoptosis sensitivity of Mcl-1 expressing HCC cells to chemotherapy after inhibition of PI3K, but not after inhibition of Jak2, mTOR, MEK1, Src or Raf I kinase
Negative_regulation (inhibition) of PI3K associated with carcinoma and apoptosis
10) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.90 Pain Relevance 0.06
Furthermore, Mcl-1 downregulation further augmented apoptosis caused by combination therapy with PI3K inhibition and chemotherapeutics.
Negative_regulation (inhibition) of PI3K associated with apoptosis
11) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.18 Pain Relevance 0
We have already shown that inhibition of PI3 kinase reduced expression of Mcl-1 in Hep3B cells and sensitized cells towards apoptosis induction by bleomycin [27].
Negative_regulation (inhibition) of PI3 kinase associated with apoptosis
12) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.89 Pain Relevance 0
In this study we tested the effect of PI3K inhibition on Mcl-1 expression and apoptosis sensitivity in the HCC cell line Huh7.
Negative_regulation (inhibition) of PI3K associated with carcinoma and apoptosis
13) Confidence 0.23 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 0.95 Pain Relevance 0
In the current study, PI3K inhibition for 48 h led to apoptosis rates of about 20%.
Negative_regulation (inhibition) of PI3K associated with apoptosis
14) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.22 Pain Relevance 0
Inhibition of the PI 3-kinase/Akt signaling pathway reduces phosphorylation of I?
Negative_regulation (Inhibition) of PI 3-kinase
15) Confidence 0.11 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.66 Pain Relevance 0
Various PI 3-kinase inhibitors such as Wortmannin, LY294002 and dominant-negative Akt expression vector were used to fully prove the involvement of PI 3-K/Akt pathway in the regulation of NF-?
Negative_regulation (inhibitors) of PI 3-kinase
16) Confidence 0.11 Published 2004 Journal Mol Cancer Section Body Doc Link PMC394342 Disease Relevance 0.17 Pain Relevance 0
These effects were abrogated through blockade of PI-3K signaling by wortmannin.
Negative_regulation (blockade) of PI-3K
17) Confidence 0.09 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.30 Pain Relevance 0.12
RISK pathway is also involved in the cardioprotective mechanism of postconditioning and the inhibition of PI3 kinase abrogates protection conferred by postconditioning (Tsang et al 2004).
Negative_regulation (inhibition) of PI3 kinase
18) Confidence 0.01 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.22 Pain Relevance 0.07
Pharmacological inhibitors of phosphoinositide-3 kinase (PI3-K) and the rho-activated kinase (ROCK) attenuate VEGF-induced LIMK phosphorylation that indicates a role for (PI3-K) and ROCK in the signaling pathways leading to regulation of LIMK activity [36].
Negative_regulation (inhibitors) of PI3-K
19) Confidence 0.01 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1456963 Disease Relevance 0.06 Pain Relevance 0

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