INT89404
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
[Efficacy of tumor necrosis factor-alpha blockade for severe sciatica?]. | |||||||||||||||
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Understanding the role of tumor necrosis factor inhibition in ankylosing spondylitis. | |||||||||||||||
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TNFalpha blockade, however, is a treatment, rather than a cure, and is not effective in all patients or in all autoimmune diseases and further research is needed to get closer to a cure. | |||||||||||||||
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antibodies resulted in suppression of not only TNF-? | |||||||||||||||
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It may therefore be possible that under these experimental conditions, a salicylic acid-mediated mechanism is responsible for the inhibition of TNF? | |||||||||||||||
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Rationale for using tumor necrosis factor inhibition to treat systemic lupus erythematosus | |||||||||||||||
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The recent introduction of tumor necrosis factor (TNF) blockers in the treatment of spondyloarthritis has offered the most hope in not only relieving symptoms and signs of both peripheral arthritis and enthesitis but also spinal disease, which often has been refractory to other agents. | |||||||||||||||
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The recent introduction of tumor necrosis factor (TNF) blockers in the treatment of spondyloarthritis has offered the most hope in not only relieving symptoms and signs of both peripheral arthritis and enthesitis but also spinal disease, which often has been refractory to other agents. | |||||||||||||||
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SUMMARY: The introduction of tumor necrosis factor inhibitors for patients with ankylosing spondylitis and psoriatic arthritis has had a tremendous impact on daily clinical care.
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Although more research is needed on the potential role for TNF-alpha inhibition of insulin action, elevated TNF-alpha production after muscle damage may impair insulin signal transduction. | |||||||||||||||
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plays an important role in host defence against infection, inhibition of TNF-? | |||||||||||||||
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Although the evidence for therapeutic efficacy of TNF blockade in SLE is still limited, there are a minimum of 28 cases reported at least in abstract form [56-61] and most of these are on the use of the chimeric monoclonal antibody infliximab.
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The effect of tumor necrosis factor blockade on the response to pneumococcal vaccination in patients with rheumatoid arthritis and ankylosing spondylitis. | |||||||||||||||
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Clinical studies of TNF inhibitors and congestive heart failure | |||||||||||||||
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For patients who do not respond to tumor necrosis factor blockade, several treatment options are under study. | |||||||||||||||
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The differences between the effects of TNF blockade on IFN response activity between the studies in SS [11] and SoJIA [9], on the one hand, and our studies in RA and spondyloarthritis (SpA) [31], on the other, could have their origin in differences in design between the studies, such as the use of infliximab in RA versus etanercept in SS, and the different readout systems used. | |||||||||||||||
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Therefore, the relationship between the extent of the baseline IFN response gene expression levels and its change after TNF blockade was tested. | |||||||||||||||
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However, the regulation of IFN response genes upon TNF blockade was highly variable between patients. | |||||||||||||||
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The mechanisms responsible for the differential effects of TNF? | |||||||||||||||
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and p38 phosphorylation; treatment with inhibitors of either TNF-? | |||||||||||||||
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