INT89407

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Context Info
Confidence 0.51
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 17
Disease Relevance 9.67
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRS1) signal transduction (IRS1) plasma membrane (IRS1)
nucleus (IRS1) cytoplasm (IRS1) signal transducer activity (IRS1)
Anatomy Link Frequency
skeletal muscle 4
lymphocytes 1
muscle 1
IRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 108 99.98 Very High Very High Very High
Pain 10 99.40 Very High Very High Very High
Inflammation 118 89.84 High High
withdrawal 8 71.96 Quite High
antagonist 4 27.76 Quite Low
tolerance 18 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 422 99.84 Very High Very High Very High
Insulin Resistance 164 99.82 Very High Very High Very High
Stress 12 99.06 Very High Very High Very High
Diabetes Mellitus 126 97.20 Very High Very High Very High
Obesity 56 96.68 Very High Very High Very High
Overnutrition 56 91.28 High High
INFLAMMATION 118 89.84 High High
Hyperinsulinism 16 83.52 Quite High
Hypertension 58 79.36 Quite High
Vascular Disease 32 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, activated IRS-1 modulates the phosphoinositide 3-kinase (PI3K) that in turn indirectly stimulates the activity of mTOR [19].
Positive_regulation (activated) of IRS-1
1) Confidence 0.51 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.66 Pain Relevance 0.03
f; Figure 3) includes activation of IRS1 and its subsequent activation of X, which refers to some non-identified downstream signaling intermediate.
Positive_regulation (activation) of IRS1
2) Confidence 0.41 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2424138 Disease Relevance 0 Pain Relevance 0
This would suggest: 1) that cytokines impair IRS-1 activity, blocking anabolic insulin signaling cascade with less activated mTOR and 2) that the molecular mechanism of leptin-mediated impairment of insulin signaling is similar in both skeletal muscle and lymphocytes.
Positive_regulation (impair) of IRS-1 in lymphocytes associated with cytokine
3) Confidence 0.37 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.86 Pain Relevance 0.14
In summary, the physiological stress associated with muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase, presumably leading to decreased insulin-mediated glucose uptake.
Positive_regulation (stimulation) of IRS-1 in muscle associated with stress
4) Confidence 0.35 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10893341 Disease Relevance 0.36 Pain Relevance 0.03
Muscle damage impairs insulin stimulation of IRS-1, PI 3-kinase, and Akt-kinase in human skeletal muscle.
Positive_regulation (stimulation) of IRS-1 in skeletal muscle associated with cytokine
5) Confidence 0.35 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Title Doc Link 10893341 Disease Relevance 0.57 Pain Relevance 0.19
When IRS-1 is activated, it stimulates GLUT 4, with consequent regulation of glucose and lipid intracellular metabolism.
Positive_regulation (activated) of IRS-1
6) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.63 Pain Relevance 0.03
Surprisingly, in our study p-serine-636/639-IRS-1 was significantly less in patients with MetS while there was a slight increased total IRS-1, although this was not statistical significant.
Positive_regulation (increased) of IRS-1 associated with metabolic syndrome
7) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.66 Pain Relevance 0.12
Indirect confirmation was the slightly increased total IRS-1, suggesting the cell's attempt to maintain adequate total concentrations of IRS-1 which could be activated or inactivated in response to specific stimuli.
Positive_regulation (increased) of IRS-1
8) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 1.06 Pain Relevance 0.09
Current understanding of insulin signaling regulation considers IRS-1 to be a key protein in this cascade and mTOR activation.
Positive_regulation (activation) of IRS-1
9) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.70 Pain Relevance 0
Therefore, IS of insulin seems to be impaired at least at the IRS-1 level in MetS.
Positive_regulation (level) of IRS-1 associated with metabolic syndrome
10) Confidence 0.34 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.65 Pain Relevance 0.04
In contrast, HF overfeeding increased skeletal muscle serine phosophorylation of IRS-1 (p < 0.001) and increased total expression of p85?
Positive_regulation (increased) of IRS-1 in skeletal muscle
11) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2761378 Disease Relevance 0.23 Pain Relevance 0
The IRS-1 associated p110 was significantly increased following HC overfeeding (Figure 3B), supporting a positive influence of the HC diet on PI 3-kinase activity.
Positive_regulation (increased) of IRS-1
12) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0 Pain Relevance 0
Assessment of skeletal muscle insulin signaling demonstrated increased tyrosine phosphorylation of IRS-1 (p < 0.001) and increased IRS-1-associated phosphatidylinositol 3 (PI 3)-kinase activity (p < 0.001) following HC overfeeding.
Positive_regulation (increased) of IRS-1-associated in skeletal muscle
13) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2761378 Disease Relevance 0.26 Pain Relevance 0
We found that consuming a high-carbohydrate (HC) hypercaloric diet results in a significant increase in tyrosine phosphorylation IRS-1, with increased association of p110 (a catalytic subunit of PI 3-kinase) with IRS-1 and enhanced IRS-1-associated insulin-stimulated PI 3-kinase activity.
Positive_regulation (increase) of IRS-1
14) Confidence 0.31 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.16 Pain Relevance 0
This would suggest: 1) that cytokines impair IRS-1 activity, blocking anabolic insulin signaling cascade with less activated mTOR and 2) that the molecular mechanism of leptin-mediated impairment of insulin signaling is similar in both skeletal muscle and lymphocytes.
Positive_regulation (impair) of IRS-1 in skeletal muscle associated with cytokine
15) Confidence 0.12 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.86 Pain Relevance 0.14
induces insulin resistance through increased serine phosphorylationof insulin receptor substrate-1 (IRS-1), which subsequently converts
Positive_regulation (increased) of IRS-1 associated with insulin resistance
16) Confidence 0.12 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2615833 Disease Relevance 1.00 Pain Relevance 0
induces insulin resistance through increased serine phosphorylationof insulin receptor substrate-1 (IRS-1), which subsequently converts
Positive_regulation (increased) of receptor substrate-1 associated with insulin resistance
17) Confidence 0.10 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2615833 Disease Relevance 1.00 Pain Relevance 0

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