INT89430

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Context Info
Confidence 0.05
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ICAM4, ITGA4) extracellular region (ICAM4) cell adhesion (ITGA4)
Anatomy Link Frequency
macrophages 1
ICAM4 (Homo sapiens)
ITGA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Acute pain 2 59.04 Quite High
Disease Link Frequency Relevance Heat
Adhesions 4 99.20 Very High Very High Very High
Disease 2 75.00 Quite High
Pain 2 5.00 Very Low Very Low Very Low
Sickle Cell Anemia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations have led to the suggestion that LW gp on erythroblasts may interact with VLA-4 on macrophages to stabilize erythroblastic islands in normal bone marrow and that Lu gp may facilitate trafficking of more mature erythroid cells to the sinusoidal endothelium where alpha 5-containing laminins are known to be expressed.
LW gp Binding (interact) of VLA-4 in macrophages
1) Confidence 0.05 Published 1999 Journal Baillieres Best Pract. Res. Clin. Haematol. Section Abstract Doc Link 10895261 Disease Relevance 0.24 Pain Relevance 0.06
LW gp binds the integrin very late antigen-4 (VLA-4, alpha 4 beta 1) and alpha V-containing integrins.
LW gp Binding (binds) of VLA-4
2) Confidence 0.05 Published 1999 Journal Baillieres Best Pract. Res. Clin. Haematol. Section Abstract Doc Link 10895261 Disease Relevance 0.25 Pain Relevance 0

General Comments

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