INT89445

Context Info Confidence 0.58 First Reported 2000 Last Reported 2009 Negated 11 Speculated 0 Reported most in Body Documents 17 Total Number 17 Disease Relevance 18.07 Pain Relevance 1.55

extracellular region (MEPE) proteinaceous extracellular matrix (MEPE)

Anatomy Link Frequency smooth muscle 3 spindle cells 2 neuron 1 muscle 1 MEPE (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 15 97.20 cytokine 4 91.12 pain flank 6 89.96 Pain 15 85.44 imagery 12 82.20 palliative 4 80.44 cva 6 78.52 Angina 1 63.28 colic 4 57.68 nud 4 47.36

Disease Link Frequency Relevance Heat Disease 58 100.00 Carcinoma 37 100.00 Skin Cancer 14 100.00 Gastrointestinal Stromal Tumor 5 100.00 Lymphatic System Cancer 5 100.00 Cancer 282 99.80 Melanoma 70 99.36 Microphthalmia 2 99.16 Metastasis 111 99.08 Angiomyolipoma 5 98.48

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Disease term

The tumor cells were positive for human melanosome-associated protein (HMB-45) on immunohistochemical staining.

Gene_expression (positive) of HMB-45 associated with cancer

1) Confidence 0.58 Published 2007 Journal J. Formos. Med. Assoc. Section Abstract Doc Link 17493897 Disease Relevance 1.49 Pain Relevance 0.09

Muscle markers (desmin and smooth muscle actin) were positive diffusely and strongly in the spindle cells of all tumors, whereas HMB-45 and CD34 were absent.

Neg (absent) Gene_expression (absent) of HMB-45 in spindle cells associated with cancer

2) Confidence 0.19 Published 2000 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 10895818 Disease Relevance 1.09 Pain Relevance 0.06

The morules showed positive thyroid transcription factor-1 staining, weak keratin staining, and negative staining for smooth muscle actin, desmin, and HMB-45.

Gene_expression (staining) of HMB-45 in smooth muscle

3) Confidence 0.14 Published 2004 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 15272538 Disease Relevance 0.87 Pain Relevance 0.10

Immunohistochemically, the tumor cells are usually positive for S-100 protein, HMB-45 and vimentin and/or microphthalmia transcription factor [14].

Gene_expression (positive) of HMB-45 associated with cancer and microphthalmia

4) Confidence 0.08 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1555585 Disease Relevance 0.97 Pain Relevance 0.04

There have been reports on S-100 positivity and HMB-45 negativity of this tumor type, but to the best of our knowledge, this is the first description of an EMPNST positive for MBP, chromogranin A, and synaptophisin.

Neg (negativity) Gene_expression (negativity) of HMB-45 associated with cancer

5) Confidence 0.07 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.16 Pain Relevance 0.22

Immunohistochemically, the tumor cells proved positive for S-100, NSE, GFAP, MBP, chromogranin A and synaptophysin, and negative for CEA, keratin, HMB-45, G-CSF, and GM-CSF.

Neg (negative) Gene_expression (negative) of HMB-45 associated with cancer

6) Confidence 0.06 Published 2005 Journal Pathol. Res. Pract. Section Abstract Doc Link 15991844 Disease Relevance 1.34 Pain Relevance 0.26

Estrogen receptor (ER), Progesterone receptor (PR) and HMB 45 (Human melanoma antibody) were negative.

Neg (negative) Gene_expression (negative) of HMB 45 associated with skin cancer

7) Confidence 0.05 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC1215508 Disease Relevance 0.79 Pain Relevance 0.04

The immunohistochemical stains for melanoma (S100, tyrosinase, Melan A and HMB-45), carcinoma (CK), gastrointestinal stromal tumours (CD-34, vimentin and c-Kit) and lymphoma (LCA) were performed with negative results, except for a weak and focal expression of vimentin.

Gene_expression (expression) of HMB-45 associated with lymphatic system cancer, melanoma, carcinoma and gastrointestinal stromal tumor

8) Confidence 0.03 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2396655 Disease Relevance 1.64 Pain Relevance 0.06

The spindle cells were diffuse positive for VIM, ACT, CD68 and negative for desmin, MNF116, SyN, S100, HMB45, and CD117.

Neg (negative) Gene_expression (negative) of HMB45 in spindle cells

9) Confidence 0.03 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.84 Pain Relevance 0.21

Fragments of the tumor were fixed in 10% formaldehyde, included in paraffin, and the sections were stained with HE, VG and immunohistochemically with vimentin (VIM), MNF116, SyN, smooth muscle actin (ACT), desmin, CD68, S100, HMB45, and CD117.

Gene_expression (stained) of HMB45 in smooth muscle associated with cancer

10) Confidence 0.03 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.93 Pain Relevance 0.23

The positive expression of the HMB-45 and S-100 protein antibodies set the diagnosis of the malignant neoplasm of melanocytic origin (malignant melanoma) as the most prevalent.

Gene_expression (expression) of HMB-45 associated with malignant neoplastic disease, melanoma and cancer

11) Confidence 0.02 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2731760 Disease Relevance 1.44 Pain Relevance 0

Immunoperoxidase testing was positive for CD10 and vimentin and negative for gross cystic disease fluid protein (GCDFP), S-100, HMB-45, muscle-specific antigen, and desmin, supporting the diagnosis of metastatic RCC (Figure 3).

Neg (negative) Gene_expression (negative) of HMB-45 in muscle associated with renal cell carcinoma and disease

12) Confidence 0.02 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566576 Disease Relevance 0.79 Pain Relevance 0

Melan A and HMB45 were negative excluding a melanocytic lesion or an angiomyolipoma.

Neg (negative) Gene_expression (negative) of HMB45 associated with angiomyolipoma

13) Confidence 0.02 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2430707 Disease Relevance 1.05 Pain Relevance 0.09

The tumour cells expressed S-100 protein and glial fibrillary acidic protein (GFAP) and were negative for HMB45, melan A, smooth muscle actin (SMA), desmin, CD34 and CD117.

Neg (negative) Gene_expression (negative) of HMB45 in smooth muscle associated with cancer

14) Confidence 0.02 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2430707 Disease Relevance 0.65 Pain Relevance 0

Immunohistochemical staining showed that the cells expressed neuroendocrine markers (synaptophysin, chromogranin, NSE) and cytokeratin marker (CAM 5.2) but were negative for S100, HMB45, CD99 and CD117.

Neg (negative) Gene_expression (negative) of HMB45

15) Confidence 0.01 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 0.76 Pain Relevance 0.07

These were negative for cytokeratin (AE1/AE3), HMB45, S100 protein, melanin A, NSE (neuron specific enolase), CD34 and CD 117.

Neg (negative) Gene_expression (negative) of HMB45 in neuron

16) Confidence 0.01 Published 2008 Journal Cases J Section Body Doc Link PMC2584078 Disease Relevance 0.96 Pain Relevance 0.08

Immunohistochemistry showed strong and diffuse positive staining for neuroendocrine markers (NSE, chromogranin, synaptophysin) and CAM 5.2 but was negative for EMA, S100 and HMB45.

Neg (negative) Gene_expression (negative) of HMB45

17) Confidence 0.01 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.28 Pain Relevance 0

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