INT89467

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 1.59
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Lhcgr) endoplasmic reticulum (Lhcgr) cytoplasm (Lhcgr)
signal transducer activity (Lhcgr) extracellular space (Lhcgr) extracellular region (Lhcgr)
Anatomy Link Frequency
luteal cells 3
follicles 2
puncture 1
granulosa cells 1
Lhcgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
MU agonist 6 99.60 Very High Very High Very High
Opioid 12 98.20 Very High Very High Very High
anesthesia 3 86.92 High High
metalloproteinase 4 77.20 Quite High
agonist 16 51.68 Quite High
cINOD 4 24.24 Low Low
antagonist 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 3 99.60 Very High Very High Very High
Adrenocortical Hyperfunction 12 99.22 Very High Very High Very High
Targeted Disruption 24 80.92 Quite High
Hyperplasia 3 76.76 Quite High
Polycystic Ovary Syndrome 24 58.28 Quite High
Hyperinsulinism 4 51.92 Quite High
Anovulation 4 45.92 Quite Low
Hyperandrogenism 4 45.40 Quite Low
Reprotox - General 3 4 42.12 Quite Low
Diabetes Mellitus 4 35.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that LHR gene expression in porcine luteal cells can be regulated by opioid peptides.
Gene_expression (expression) of LHR gene in luteal cells associated with opioid
1) Confidence 0.36 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10898106 Disease Relevance 0 Pain Relevance 0.25
The LHR gene expression was observed in non-stimulated LLCs and in both types of cells after treatment with FK or hCG.
Gene_expression (expression) of LHR gene
2) Confidence 0.36 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10898106 Disease Relevance 0 Pain Relevance 0.23
FK stimulated LHR gene expression in SLCs and inhibited the gene expression in LLCs.
Gene_expression (expression) of LHR gene
3) Confidence 0.36 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10898106 Disease Relevance 0 Pain Relevance 0.24
Reverse transcription-polymerase chain reaction (RT-PCR) and Southern hybridization were used to check the effect of FK and hCG on LHR gene expression.
Gene_expression (expression) of LHR gene
4) Confidence 0.36 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10898106 Disease Relevance 0 Pain Relevance 0.23
The aim of the present studies was to investigate (1) the presence of LH receptor (LHR) in porcine separated small (SLCs) and large (LLCs) luteal cells taken from mid-luteal corpora lutea and (2) the influence of opioid agonist, FK 33-824 (FK) on LHR gene expression in these cells.
Gene_expression (expression) of LHR gene in luteal cells associated with mu agonist
5) Confidence 0.36 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10898106 Disease Relevance 0 Pain Relevance 0.17
The aim of the present studies was to investigate (1) the presence of LH receptor (LHR) in porcine separated small (SLCs) and large (LLCs) luteal cells taken from mid-luteal corpora lutea and (2) the influence of opioid agonist, FK 33-824 (FK) on LHR gene expression in these cells.
Spec (investigate) Gene_expression (presence) of LH receptor in luteal cells associated with mu agonist
6) Confidence 0.32 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10898106 Disease Relevance 0 Pain Relevance 0.17
is lower in follicles expressing the LH receptor compared to those that do not express the LH receptor [31], and expression of PPAR?
Neg (not) Gene_expression (express) of LH receptor in follicles
7) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2795759 Disease Relevance 0.06 Pain Relevance 0.04
is lower in follicles expressing the LH receptor compared to those that do not express the LH receptor [31], and expression of PPAR?
Gene_expression (expressing) of LH receptor in follicles
8) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2795759 Disease Relevance 0.11 Pain Relevance 0.04
As expression of the LH receptor increases, the relative expression of PPAR?
Gene_expression (expression) of LH receptor
9) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2795759 Disease Relevance 0.08 Pain Relevance 0.03
Its expression is relatively high in granulosa cells prior to the developmental point when granulosa cells express the LH receptor [31].
Gene_expression (express) of LH receptor in granulosa cells
10) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2795759 Disease Relevance 0.08 Pain Relevance 0
This condition may be defined as a disease resulting from the expression of LH-R on sex steroid-producing adrenocortical cells.
Gene_expression (expression) of LH-R associated with disease
11) Confidence 0.07 Published 2002 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 12431804 Disease Relevance 0.47 Pain Relevance 0.07
This condition may be defined as a disease resulting from the expression of LH-R on sex steroid-producing adrenocortical cells.
Gene_expression (expression) of LH-R associated with disease
12) Confidence 0.06 Published 2002 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 12431804 Disease Relevance 0.47 Pain Relevance 0.07
Four studies were performed to test the hypothesis that gonadotrophic hormones, and particularly luteinizing hormone (LH) play a role in the pathogenesis of ferrets: (I) adrenal glands of ferrets with hyperadrenocorticism were studied immunohistochemically to detect LH-receptors (LH-R); (II) gonadotrophin-releasing hormone (GnRH) stimulation tests were performed in 10 neutered ferrets, with measurement of androstenedione, 17alpha-hydroxyprogesterone and cortisol as endpoints; (III) GnRH stimulation tests were performed in 15 ferrets of which 8 had hyperadrenocorticism, via puncture of the vena cava under anesthesia; and (IV) urinary corticoid/creatinine (C/C) ratios were measured at 2-week intervals for 1 year in the same ferrets as used in study II.
Gene_expression (detect) of LH-R in puncture associated with anesthesia and adrenocortical hyperfunction
13) Confidence 0.06 Published 2002 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 12431804 Disease Relevance 0.32 Pain Relevance 0.09

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