INT89475

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Context Info
Confidence 0.61
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 3.64
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (TGFB1, PTHLH) extracellular space (TGFB1, PTHLH) extracellular region (TGFB1, PTHLH)
nucleus (TGFB1, PTHLH) aging (TGFB1) Golgi apparatus (PTHLH)
TGFB1 (Homo sapiens)
PTHLH (Homo sapiens)
Pain Link Frequency Relevance Heat
Mechanotransduction 40 99.28 Very High Very High Very High
Pain 7 86.64 High High
metalloproteinase 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 234 100.00 Very High Very High Very High
Breast Cancer 34 100.00 Very High Very High Very High
Hypercalcemia 31 100.00 Very High Very High Very High
Osteolysis 17 100.00 Very High Very High Very High
Osteoporosis 14 100.00 Very High Very High Very High
Bone Cancer 30 98.44 Very High Very High Very High
Syndrome 2 88.96 High High
Pain 7 86.64 High High
Metastasis 117 85.04 High High
Disease 12 84.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: TGFbeta promoted the development and progression of osteolytic bone metastases by inducing tumor production of PTHrP, the effect of which was mediated through the Smad signaling pathway.
TGFbeta Positive_regulation (inducing) of Gene_expression (production) of PTHrP
1) Confidence 0.61 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.16 Pain Relevance 0
Transforming growth factor beta (TGFbeta), which is abundant in bone matrix and is released as a consequence of osteoclastic bone resorption, may promote breast carcinoma osteolysis by stimulating PTHrP production by tumor cells.
TGFbeta Positive_regulation (stimulating) of Gene_expression (production) of PTHrP associated with cancer, breast cancer, osteolysis, hypercalcemia and osteoporosis
2) Confidence 0.61 Published 2000 Journal Cancer Section Abstract Doc Link 10898330 Disease Relevance 1.29 Pain Relevance 0.09
Our data show that the increased PTHrP expression induced by exogenous TGF-ß in vitro is mediated by the rigidity of the substrate on which the tumor cells are cultured.
TGF Positive_regulation (induced) of Gene_expression (expression) of PTHrP associated with cancer
3) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.60 Pain Relevance 0.04
Furthermore, cells expressing a dominant negative form of the TGF-ß receptor did not respond to substrate rigidity, and inhibition of ROCK decreased PTHrP expression induced by exogenous TGF-ß.
TGF Positive_regulation (induced) of Gene_expression (expression) of PTHrP
4) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.56 Pain Relevance 0
Furthermore, cells expressing a dominant negative form of the TGF-ß receptor did not respond to substrate rigidity, and inhibition of ROCK decreased PTHrP expression induced by exogenous TGF-ß.
TGF Positive_regulation (induced) of Gene_expression (expression) of PTHrP
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2981576 Disease Relevance 0.81 Pain Relevance 0
We next investigated whether blocking ROCK inhibits the effects of exogenous TGF-ß on the stimulation of Gli2 and PTHrP expression by treating cells with TGF-ß and inhibiting mechanotransduction with blebbistatin (Figure 6A and B) or Y27632 (Figure 6C and D).
TGF Positive_regulation (stimulation) of Gene_expression (expression) of PTHrP associated with mechanotransduction
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.13 Pain Relevance 0.05
While Figure 4 shows that ROCK regulates PTHrP expression, TGF-ß is also known to stimulate PTHrP production [5].
TGF Positive_regulation (stimulate) of Gene_expression (production) of PTHrP
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.09 Pain Relevance 0.03

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