INT89477

Context Info Confidence 0.14 First Reported 2000 Last Reported 2000 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.15 Pain Relevance 0

extracellular region (PTHLH, TNFRSF11B) Golgi apparatus (PTHLH) intracellular (PTHLH) extracellular matrix organization (TNFRSF11B) cell-cell signaling (PTHLH) cytoplasm (PTHLH)

Anatomy Link Frequency osteoblast 2 PTHLH (Homo sapiens) TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 1 5.00

Disease Link Frequency Relevance Heat Cancer 2 74.12 Osteolysis 1 72.48 Metastasis 1 50.00 Hypercalcemia 3 5.00 Breast Cancer 2 5.00 Osteoporosis 2 5.00 Pain 1 5.00 Syndrome 1 5.00 Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PTHrP stimulated osteoclastic bone resorption by increasing osteoblast production of the receptor activator of nuclear factor K B (RANK) ligand and decreasing osteoblast production of osteoprotegerin (OPG).

PTHrP Negative_regulation (decreasing) of Gene_expression (production) of osteoprotegerin in osteoblast

1) Confidence 0.14 Published 2000 Journal Cancer Section Body Doc Link 10898330 Disease Relevance 0.15 Pain Relevance 0

General Comments

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