INT895

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Context Info
Confidence 0.55
First Reported 1979
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 2.45
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 2
neurohypophysis 2
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 6 100.00 Very High Very High Very High
Neuropeptide 2 100.00 Very High Very High Very High
Dynorphin 6 99.76 Very High Very High Very High
narcan 6 99.54 Very High Very High Very High
Morphine 2 99.48 Very High Very High Very High
antagonist 2 98.84 Very High Very High Very High
Enkephalin 3 97.76 Very High Very High Very High
Dismenorea 1 94.96 High High
fluoxetine 2 89.20 High High
Neurotransmitter 1 89.08 High High
Disease Link Frequency Relevance Heat
Hyponatremia 9 99.74 Very High Very High Very High
Cancer 4 95.76 Very High Very High Very High
Aggression 7 95.20 Very High Very High Very High
Dysmenorrhea 1 94.96 High High
Syndrome 1 90.00 High High
Stress 1 87.12 High High
Pain 2 85.08 High High
Vomiting 2 84.40 Quite High
Cirrhosis 1 84.40 Quite High
Heart Rate Under Development 1 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TREATMENT: The AVP-receptor antagonists, a new class of agents, correct hyponatremia by directly blocking the binding of AVP with its receptors.
Negative_regulation (blocking) of AVP Binding (binding) of associated with hyponatremia and antagonist
1) Confidence 0.55 Published 2007 Journal Support Care Cancer Section Abstract Doc Link 17701059 Disease Relevance 1.55 Pain Relevance 0.13
Further, there is no evidence from these or our prior studies for a close interrelationship of spinal cord vasopressin with dynorphin-related peptides (or oxytocin with [Met]enkephalin), likewise in contrast to the neurohypophysis.
Negative_regulation (close) of vasopressin Binding (interrelationship) of in neurohypophysis associated with dynorphin, enkephalin and spinal cord
2) Confidence 0.41 Published 1984 Journal Neuroscience Section Abstract Doc Link 6149493 Disease Relevance 0.06 Pain Relevance 0.80
These morphological data predispose a functional interaction between AVP and 5-HT at the level of the AH.
Negative_regulation (predispose) of AVP Binding (interaction) of
3) Confidence 0.33 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9151749 Disease Relevance 0.75 Pain Relevance 0.26
Pretreatment with the neuropeptide DG-AVP (desglycrinamide9-arginine8-vasopressin) at two dose levels (25 and 125 mcg/kg) did not reduce intravenous morphine self-administration (0.25 mg/kg/inj) by morpine dependent monkeys, in comparison to pretreatment with saline or DG-AVP vehicle placebo.
Neg (not) Negative_regulation (reduce) of DG-AVP Binding (Pretreatment) of associated with neuropeptide and morphine
4) Confidence 0.22 Published 1979 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 109866 Disease Relevance 0 Pain Relevance 0.26
CONCLUSION: Intraperitoneal bupivacaine administration both immediately after placement of trocars and at the end of surgery was found to be effective in reducing the intensity of AVP but not in reducing STP, APP, or postoperative analgesia consumption after nonadvanced gynecologic laparoscopic procedures.
Negative_regulation (reducing) of AVP Binding (intensity) of
5) Confidence 0.15 Published 2005 Journal Journal of minimally invasive gynecology Section Body Doc Link 16036193 Disease Relevance 0 Pain Relevance 0
When incubated with purified plasma membranes from rat or human myometrial tissue, OPC-21268 inhibited the specific receptor binding of tritiated oxytocin and vasopressin in a dose-dependent and reversible way.
Negative_regulation (inhibited) of vasopressin Binding (binding) of in plasma
6) Confidence 0.08 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566118 Disease Relevance 0.09 Pain Relevance 0.14
Influence on memory of posttraining or pre-test injections of ACTH, vasopressin, epinephrine, and beta-endorphin, and their interaction with naloxone.
Negative_regulation (posttraining) of vasopressin Binding (injections) of associated with narcan
7) Confidence 0.03 Published 1985 Journal Psychoneuroendocrinology Section Title Doc Link 2994140 Disease Relevance 0 Pain Relevance 0.30

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