INT8950

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Context Info
Confidence 0.76
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 0.97
Pain Relevance 4.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tacr3) plasma membrane (Tacr3) nucleus (Tacr3)
signal transducer activity (Tacr3)
Anatomy Link Frequency
lymphocytes 1
sympathetic 1
skin 1
Tacr3 (Mus musculus)
Pain Link Frequency Relevance Heat
substance P 158 100.00 Very High Very High Very High
agonist 79 100.00 Very High Very High Very High
excitatory amino acid 2 100.00 Very High Very High Very High
Central nervous system 19 99.68 Very High Very High Very High
antagonist 20 98.50 Very High Very High Very High
Opioid 5 98.28 Very High Very High Very High
narcan 5 98.06 Very High Very High Very High
MU agonist 2 92.64 High High
pruritus 71 92.56 High High
Dismenorea 2 92.36 High High
Disease Link Frequency Relevance Heat
Pruritus 82 92.56 High High
Dysmenorrhea 2 92.36 High High
Nociception 1 84.20 Quite High
Hypogonadotropic Hypogonadism 7 71.36 Quite High
Disease 7 65.96 Quite High
Pain 12 63.28 Quite High
Neurogenic Inflammation 2 53.20 Quite High
Reprotox - General 1 7 46.60 Quite Low
Suicidal Behaviour 1 32.20 Quite Low
Depression 3 31.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that E2 caused a rapid and concomitant down-regulation of Tac2 and Tacr3 expression supports the existence of an important link between E2 and the NK3R/NKB activation pathway [38].
Gene_expression (expression) of Tacr3
1) Confidence 0.76 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0.07 Pain Relevance 0
The present data show that E2 strongly reduces Tacr3 expression in uteri from ovariectomized mice.
Gene_expression (expression) of Tacr3
2) Confidence 0.76 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
Tacr3 expression was decreased in mice treated with E2 for 3 or 24 h and in mice treated with PPT for 24 h, compared with vehicle-treated mice (Fig. 3C).
Gene_expression (expression) of Tacr3
3) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0
In this study, we have analyzed the direct effects of the ovarian steroids E2 and P4 on the expression of Tac1, Tac2, Tac4, Tacr1, Tacr2 and Tacr3 in uteri from ovariectomized mice.
Spec (analyzed) Gene_expression (expression) of Tacr3
4) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.09
P4 did not modify Tacr3 expression and did not influence the E2-induced decrease in the expression of Tacr3 (Fig. 4C).


Gene_expression (expression) of Tacr3
5) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.03
All genes encoding tachykinins (Tac1, Tac2 and Tac4) and tachykinin receptors (Tacr1, Tacr2 and Tacr3) were expressed in uteri from ovariectomized mice.
Gene_expression (expressed) of Tacr3
6) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.09
P4 did not modify Tacr3 expression and did not influence the E2-induced decrease in the expression of Tacr3 (Fig. 4C).


Gene_expression (expression) of Tacr3
7) Confidence 0.59 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.03
Endpoint and real-time quantitative RT-PCR were used to analyze the expression of the genes that encode the tachykinins SP/NKA, NKB, and hemokinin-1 (HK-1) (Tac1, Tac2, and Tac4); and the genes that encode tachykinin NK1 (Tacr1), NK2 (Tacr2), and NK3 (Tacr3) receptors in uteri from pregnant and nonpregnant mice.
Spec (analyze) Gene_expression (expression) of Tacr3 associated with substance p
8) Confidence 0.58 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15647454 Disease Relevance 0.07 Pain Relevance 0.20
All three neurokinins--substance P, neurokinin A (substance K), neurokinin B (neuromedin K)--and excitatory amino acids active at N-methyl-D-aspartate (NMDA) or quisqualate receptors produce similar behaviors, which last for 1 minute after i.t. injection.
Gene_expression (produce) of neurokinin B associated with excitatory amino acid and substance p
9) Confidence 0.58 Published 1988 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2455461 Disease Relevance 0.08 Pain Relevance 0.67
Pretreatment with naloxone, an opioid antagonist, resulted in a reversible effect on the behavioural reduction of NK-2 and NK-3 receptor agonists produced by spantide.
Gene_expression (produced) of NK-3 receptor associated with antagonist, agonist, narcan and opioid
10) Confidence 0.34 Published 1992 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 1383832 Disease Relevance 0 Pain Relevance 1.01
The tachykinin NK3 receptor is expressed in considerable amounts only in uteri from nonpregnant diestrous animals, and its physiological significance remains to be clarified.
Gene_expression (expressed) of tachykinin NK3 receptor
11) Confidence 0.22 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15647454 Disease Relevance 0.09 Pain Relevance 0.18
Electrical field stimulation of isolated mouse vas deferens elicited sympathetic twitch whose amplitude was transiently enhanced by the selective tachykinin NK1 receptor agonist, [Sar9,Met(O2)11]substance P (0.3-30 nM), but not by selective NK2 and NK3 receptor agonists.
Gene_expression (agonists) of NK3 receptor in sympathetic associated with agonist and substance p
12) Confidence 0.21 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7671996 Disease Relevance 0 Pain Relevance 0.41
SP is a tachykinin which binds with different affinities to three neurokinin receptors (NKR 1–3), but mainly to NKR1, which is expressed in the central nervous system (CNS) and the skin [11].
Gene_expression (expressed) of NKR1 in skin associated with central nervous system and substance p
13) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881044 Disease Relevance 0.60 Pain Relevance 0.87
Moreover, biochemical and molecular evidence has been obtained that human [12,29,30] and murine lymphocytes [18,31] express NK-1R but not NK-2R or NK-3R.
Neg (not) Gene_expression (express) of NK-3R in lymphocytes
14) Confidence 0.01 Published 2001 Journal Respir Res Section Body Doc Link PMC2002076 Disease Relevance 0.05 Pain Relevance 0.49

General Comments

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