INT89519

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 6.26
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
cartilage 1
TMJ 1
sclera 1
extracellular matrix 1
A549 1
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 1 100.00 Very High Very High Very High
Snapping jaw 12 99.60 Very High Very High Very High
backache 3 97.08 Very High Very High Very High
endometriosis 13 93.04 High High
Osteoarthritis 8 91.92 High High
fibrosis 72 89.68 High High
Myofascial pain syndrome 2 83.84 Quite High
pain pelvic 2 78.32 Quite High
Pain 12 58.92 Quite High
local anesthetic 1 25.60 Quite Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 12 99.60 Very High Very High Very High
Neuroblastoma 50 99.40 Very High Very High Very High
Cancer 44 98.84 Very High Very High Very High
Deafness 2 97.28 Very High Very High Very High
Low Back Pain 3 97.08 Very High Very High Very High
Endometriosis (extended) 14 93.04 High High
Pulmonary Fibrosis 65 89.68 High High
Jaw Fractures 1 88.40 High High
Osteogenesis Imperfecta 23 87.80 High High
Adhesions 5 87.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients will usually present with fractures in the mildest form, but due to the qualitative and quantitative defect in type I collagen, patients may also have blue sclera, problems with dentinogenesis, hearing loss, kyphoscoliosis, and easy bruising.
Negative_regulation (defect) of type I collagen in sclera associated with deafness
1) Confidence 0.36 Published 2008 Journal Patient Saf Surg Section Body Doc Link PMC2262876 Disease Relevance 1.06 Pain Relevance 0
Type I procollagen, the carboxy-terminal telopeptide of type I collagen, and the amino-terminal of procollagen type III were all significantly decreased during OC use.
Negative_regulation (decreased) of type I collagen
2) Confidence 0.31 Published 2000 Journal Contraception Section Abstract Doc Link 10899482 Disease Relevance 0.08 Pain Relevance 0.08
Immunohistochemical staining of HUCM constructs after 4 weeks revealed a strong presence of collagen I and minute amounts of collagen II, whereas TMJ constructs revealed little collagen I and no collagen II.
Negative_regulation (presence) of collagen II in TMJ associated with snapping jaw
3) Confidence 0.29 Published 2007 Journal Tissue Eng. Section Abstract Doc Link 17518722 Disease Relevance 0.86 Pain Relevance 0.86
The most prevalent disorders result from deficiency of Type I collagen, an important extracellular matrix protein regulating both the structural and mechanical properties of most of the orofacial tissues.
Negative_regulation (deficiency) of Type I collagen in extracellular matrix
4) Confidence 0.28 Published 2004 Journal Rev Belge Med Dent Section Abstract Doc Link 15526646 Disease Relevance 0.36 Pain Relevance 0.14
Type I collagen negatively regulates cell proliferation and is deficient in aggressive neuroblastoma tumours (Yang et al. 2004).
Negative_regulation (deficient) of Type I collagen associated with neuroblastoma and cancer
5) Confidence 0.13 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.03 Pain Relevance 0
The urinary cross-linked N-terminal telopeptides of type I collagen and serum bone-specific alkaline phosphatase, osteocalcin, and undercarboxylated osteocalcin levels also markedly decreased.
Negative_regulation (decreased) of type I collagen
6) Confidence 0.09 Published 2004 Journal Keio J Med Section Abstract Doc Link 15647630 Disease Relevance 0.61 Pain Relevance 0.25
In fibroblasts, osteopontin up-regulated tissue inhibitor of metalloprotease-1 and type I collagen, and down-regulated matrix metalloprotease-1 (MMP-1) expression, while in A549 cells it caused up-regulation of MMP-7.
Negative_regulation (inhibitor) of type I collagen in A549
7) Confidence 0.08 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1198037 Disease Relevance 0.67 Pain Relevance 0.31
Significant changes were found in the morphology of the cartilage including proteoglycan loss along with decreased BMP-2 and type II procollagen mRNA staining.
Negative_regulation (decreased) of type II procollagen mRNA in cartilage
8) Confidence 0.01 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18924142 Disease Relevance 0.45 Pain Relevance 0.27
Significant decreases in bone turn over markers (BTMs) were also observed at the end of the study (49%–52% decrease in serum type I collagen C telopeptide [CTx] with ZOL vs 8% decrease in CTx with placebo; P < 0.01).
Negative_regulation (decrease) of type I collagen
9) Confidence 0.01 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2915556 Disease Relevance 0.37 Pain Relevance 0
Selected dysregulated genes were randomly chosen and validated with RT-PCR and/or Northern/dot-blot analyses, and confirmed up-regulation of collagen alpha2 type I, 2.6-fold; bile salt export pump, 2.0-fold; and down-regulation of N-acetylglucosamine-6-O-sulfotransferase (important in synthesis of L-selectin ligands), 1.7-fold; glycodelin, 51.5-fold; integrin alpha2, 1.8-fold; and B61 (Ephrin A1), 4.5-fold.
Negative_regulation (down-regulation) of collagen alpha2 type I in bile associated with bile
10) Confidence 0.00 Published 2003 Journal Endocrinology Section Abstract Doc Link 12810542 Disease Relevance 0.78 Pain Relevance 0.26

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