INT89520

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.21
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A1) extracellular region (COL1A1) cytoplasm (COL1A1)
Anatomy Link Frequency
chondrocytes 1
stellate ganglion 1
COL1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
reflex sympathetic dystrophy 41 100.00 Very High Very High Very High
Osteoarthritis 81 91.64 High High
deep brain stimulation 1 87.20 High High
Peripheral nerve stimulation 1 84.52 Quite High
Spinal cord 1 83.20 Quite High
pain pelvic 2 72.24 Quite High
Pain 32 60.92 Quite High
local anesthetic 7 18.80 Low Low
Inflammation 48 5.00 Very Low Very Low Very Low
cytokine 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 55 100.00 Very High Very High Very High
Ganglion Cysts 21 100.00 Very High Very High Very High
Osteogenesis Imperfecta 2 99.48 Very High Very High Very High
Uterine Fibroids 120 99.32 Very High Very High Very High
Syndrome 5 93.28 High High
Osteoarthritis 86 91.64 High High
Osteoporotic Fractures 4 88.88 High High
Cirrhosis 45 86.88 High High
Ring Chromosomes 10 81.64 Quite High
Metastasis 13 72.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As fibrocartilaginous collagen type I and hyaline collagen type II expression are differentially regulated in chondrocytes [34], analyzing the collagen type II/type I expression ratios is informative of chondrogenic potential [51].
Regulation (regulated) of collagen type I in chondrocytes
1) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.30 Pain Relevance 0.08
A fourfold down-regulation (0·61 ± 0·14-fold; P < 0·05) of COL1A1 gene template was observed in leiomyoma cells at concentration of 10?
Regulation (template) of COL1A1 associated with uterine fibroids
2) Confidence 0.29 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.73 Pain Relevance 0
Indeed, the osteoporotic phenotype of osteogenesis imperfecta is due to mutations that affect the coding regions of collagen type I genes [112].
Regulation (affect) of collagen type I associated with osteogenesis imperfecta
3) Confidence 0.22 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128904 Disease Relevance 0.19 Pain Relevance 0
In this way, PDGFB is placed under the control of the COL1A1 promoter that is more transcriptionally active than its own promoter.
Regulation (control) of COL1A1
4) Confidence 0.17 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.61 Pain Relevance 0
Finally, HNE seems much more selective in its activity towards HSC/MFs, since it causes the up-regulation of only a limited number of genes, including those encoding collagen type I, TGF?
Regulation (regulation) of collagen type I
5) Confidence 0.07 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.17 Pain Relevance 0
Treatment with DMSO and NAC are generally equally effective in treatment of CRPS I.
Regulation (effective) of CRPS I associated with complex regional pain syndromes
6) Confidence 0.03 Published 2003 Journal Pain Section Abstract Doc Link 12670672 Disease Relevance 0.64 Pain Relevance 0.14
The primary goal of this study was to evaluate the effects of stellate ganglion blockade treatment on CRPS type I.
Regulation (effects) of CRPS type I in stellate ganglion associated with ganglion cysts and reflex sympathetic dystrophy
7) Confidence 0.01 Published 2009 Journal J Orthop Traumatol Section Body Doc Link PMC2784060 Disease Relevance 0.50 Pain Relevance 0.37
These findings implicate OC use-induced changes in collagen type I and III turnover.
Regulation (changes) of collagen type I
8) Confidence 0.01 Published 2000 Journal Contraception Section Abstract Doc Link 10899482 Disease Relevance 0.07 Pain Relevance 0.07

General Comments

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