INT89521

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Context Info
Confidence 0.44
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.45
Pain Relevance 3.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
lymphocytes 6
mononuclear cells 2
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 105 99.96 Very High Very High Very High
cytokine 32 99.92 Very High Very High Very High
Visceral pain 12 93.20 High High
Inflammatory response 22 87.28 High High
drug abuse 1 87.24 High High
Opioid 6 79.88 Quite High
addiction 1 75.44 Quite High
Inflammatory mediators 5 75.00 Quite High
antagonist 4 70.88 Quite High
Pain 4 70.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 107 99.96 Very High Very High Very High
Infection 20 98.80 Very High Very High Very High
Hypersensitivity 86 94.16 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

12 93.20 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

15 91.00 High High
Heart Rate Under Development 3 90.12 High High
Drug Dependence 1 87.24 High High
Aging 12 85.56 High High
Pneumonia 25 81.04 Quite High
Necrosis 8 80.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results demonstrated a significant decrease in interferon-gamma production and an increase in interleukin-10 secretion in heroin addicts, relative to the control group (35.9+/-26.3 versus 110.2+/-60.3 pg/mL, p<0.01 and 71.8+/-28.4 versus 17.1+/-13.5 pg/mL, p<0.01, respectively), however the changes in these values in opium addicts were not significant compared to healthy individuals.
Positive_regulation (increase) of Localization (secretion) of interleukin-10
1) Confidence 0.44 Published 2007 Journal Eur. Cytokine Netw. Section Abstract Doc Link 17993452 Disease Relevance 0.16 Pain Relevance 0.65
In contrast, estradiol caused an increase in IL-10 and NO release by cultured-BAL cells.
Positive_regulation (increase) of Localization (release) of IL-10
2) Confidence 0.42 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2936382 Disease Relevance 0.86 Pain Relevance 0.11
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Positive_regulation (induced) of Localization (secretion) of IL-10 in lymphocytes
3) Confidence 0.39 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.51 Pain Relevance 0.55
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Positive_regulation (increasing) of Localization (release) of IL-10 in lymphocytes
4) Confidence 0.39 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.57 Pain Relevance 0.60
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Positive_regulation (increasing) of Localization (secretion) of IL-10 in lymphocytes
5) Confidence 0.39 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.57 Pain Relevance 0.58
Taken together, these results suggest an imbalance between the inflammatory (increased release of IL-6) and anti-inflammatory (increased release of IL-10) responses in acute phase of infection in aged patients.
Positive_regulation (increased) of Localization (release) of IL-10 associated with inflammation and infection
6) Confidence 0.04 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 1.00 Pain Relevance 0.48
IL-10 release was also increased (Table 1) in aged patients in acute condition.
Positive_regulation (increased) of Localization (release) of IL-10
7) Confidence 0.04 Published 2010 Journal Immun Ageing Section Body Doc Link PMC2933667 Disease Relevance 0.89 Pain Relevance 0.54
The in vitro release of tumor necrosis factor-alpha and interleukin-10 by stimulated mononuclear cells was increased.
Positive_regulation (increased) of Localization (release) of interleukin-10 in mononuclear cells
8) Confidence 0.02 Published 2000 Journal Digestion Section Body Doc Link 10899720 Disease Relevance 0.06 Pain Relevance 0

General Comments

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