INT89543

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Context Info
Confidence 0.75
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 10.60
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NEFL)
Anatomy Link Frequency
neurons 5
blood 2
cortex 2
cell body 1
Mouse 1
NEFL (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 10 98.88 Very High Very High Very High
Opioid 11 98.04 Very High Very High Very High
Multiple sclerosis 120 93.40 High High
cytokine 31 92.24 High High
methadone 1 89.52 High High
opiate 1 88.32 High High
rheumatoid arthritis 11 86.72 High High
addiction 9 82.76 Quite High
cva 352 82.12 Quite High
Neuritis 1 81.76 Quite High
Disease Link Frequency Relevance Heat
Lyme Neuroborreliosis 53 99.04 Very High Very High Very High
Disease 102 98.72 Very High Very High Very High
Atherosclerosis 34 98.68 Very High Very High Very High
Neurodegenerative Disease 64 98.52 Very High Very High Very High
Ganglion Cysts 38 98.20 Very High Very High Very High
Herpes Simplex Encephalitis 1 98.04 Very High Very High Very High
Stress 24 97.76 Very High Very High Very High
Targeted Disruption 7 97.16 Very High Very High Very High
Motor Neuron Diseases 107 96.02 Very High Very High Very High
Oligodendroglioma 57 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some studies show that axonal cytoskeletal proteins such as actin, tubulin or the neurofilament light subunit (NFL) can be detected in CSF and blood from patients with neurodegenerative conditions and that the presence of these proteins might serve as useful confirmation of neurodegeneration or MS progression [25,26].
Gene_expression (detected) of NFL in blood associated with multiple sclerosis and neurodegenerative disease
1) Confidence 0.75 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.82 Pain Relevance 0.21
However, the CSF NFL levels were low compared to other CNS diseases such as herpes encephalitis [25].
Gene_expression (levels) of NFL associated with central nervous system, herpes simplex encephalitis and disease
2) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2902447 Disease Relevance 1.20 Pain Relevance 0.15
A1 hybrid neurons express neuron-specific markers such as neurofilament-L (NF-L), NF-M, NF-H, MAP-2, and beta tubulin III.
Gene_expression (express) of NF-L in neuron
3) Confidence 0.60 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.31 Pain Relevance 0.14
A1 hybrid neurons express neuron-specific markers such as neurofilament-L (NF-L), NF-M, NF-H, MAP-2, and beta tubulin III.
Gene_expression (express) of neurofilament-L in neuron
4) Confidence 0.60 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12460557 Disease Relevance 0.31 Pain Relevance 0.14
Decreased levels of nonphosphorylated NF-H (42-32%), NF-M (14-9%) and NF-L (30-29%) were found in the prefrontal cortex of opioid addicts compared with sex, age, and postmortem delay-matched controls.
Gene_expression (levels) of NF-L in cortex associated with opioid
5) Confidence 0.51 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.25 Pain Relevance 0.86
Biochemical characterization by western blotting revealed that 1 and 5 mM concentrations of TOCP significantly inhibited the expression of neurofilament high molecular weight protein (NF-H), and that 5 mM TOCP inhibited expression of microtubule-associated protein 2c and tau protein, but not beta-actin.
Gene_expression (expression) of neurofilament high molecular weight protein
6) Confidence 0.43 Published 2006 Journal Mol. Cell. Biochem. Section Abstract Doc Link 16909309 Disease Relevance 0.31 Pain Relevance 0.08
Mouse monoclonal antibodies specific for NF-L, NF-M and tubulin-?
Gene_expression (specific) of NF-L in Mouse
7) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0 Pain Relevance 0
Low molecular weight neurofilament protein (NF-L), found in young immature neurons, increased considerably after 2 weeks of bFGF treatment and expression of mature NF forms, NF-M and NF-H, appeared after bFGF treatment.
Gene_expression (expression) of NF-L in neurons
8) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.06 Pain Relevance 0
Some studies show that axonal cytoskeletal proteins such as actin, tubulin or the neurofilament light subunit (NFL) can be detected in CSF and blood from patients with neurodegenerative conditions and that the presence of these proteins might serve as useful confirmation of neurodegeneration or MS progression [25,26].
Gene_expression (detected) of neurofilament light subunit in blood associated with multiple sclerosis and neurodegenerative disease
9) Confidence 0.26 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.83 Pain Relevance 0.22
For example, increased cell body size in transgenic rat motor neurons overexpressing the high molecular weight component of neurofilaments (NF-H) can be reduced by concurrrently increasing the expression of the low molecular weight component (NF-L) [19].
Gene_expression (expression) of NF-L in cell body associated with targeted disruption
10) Confidence 0.24 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079867 Disease Relevance 0.16 Pain Relevance 0
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of neurofilament protein in astrocytes
11) Confidence 0.23 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.66 Pain Relevance 0.18
Low molecular weight neurofilament protein (NF-L), found in young immature neurons, increased considerably after 2 weeks of bFGF treatment and expression of mature NF forms, NF-M and NF-H, appeared after bFGF treatment.
Gene_expression (expression) of Low molecular weight neurofilament protein in neurons
12) Confidence 0.23 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.11 Pain Relevance 0
Our analysis reveals the alteration of two major components of the neuronal cytoskeleton in the ALS motor cortex at the mRNA level, showing a general down-regulation of microtubules by pathway-based analysis and deregulation of two genes encoding tubulin beta (TUBB2A, TUBB6), as well as decreased expression of all three neurofilament subunits (NEFL, NEF3, NEFH).
Gene_expression (expression) of NEFL in cortex associated with motor neuron diseases
13) Confidence 0.21 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1796866 Disease Relevance 0.83 Pain Relevance 0
The M2 receptor was localized to the outer segments of the photoreceptor layer, OPL, IPL, and the nerve fiber layer (NFL) while the M3 receptor exhibited a quite distinctive expression in the OPL and NFL with processes extending through the INL and terminating at the IPL, which may be consistent with Müller cell expression.
Gene_expression (expression) of NFL in nerve
14) Confidence 0.10 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2649308 Disease Relevance 0.09 Pain Relevance 0
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of neurofilament protein in stem cells
15) Confidence 0.08 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.66 Pain Relevance 0.18
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of neurofilament protein in neurons
16) Confidence 0.08 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.66 Pain Relevance 0.18
One of the cell lines, HM3.B10 (B10), was found to differentiate into neural cell types including neural stem cells, neurons, astrocytes and oligodendrocytes in vitro as shown by expression of genetic markers for neural stem cells (nestin and Musashi1), neurons (neurofilament protein, synapsin and MAP2), astrocytes (glial fibrillary acidic protein, GFAP) and oligodendrocytes (myelin basic protein, MBP) as determined by RT-PCR assay.
Gene_expression (expression) of neurofilament protein in oligodendrocytes
17) Confidence 0.08 Published 2007 Journal PLoS ONE Section Abstract Doc Link PMC2092394 Disease Relevance 0.66 Pain Relevance 0.18
Only rare oligodendroglial cells stained with neurofilament protein, although entrapped axons in this component were consistent with an infiltrative growth pattern (e).
Gene_expression (stained) of neurofilament protein
18) Confidence 0.05 Published 2010 Journal Acta Neuropathol Section Body Doc Link PMC2892612 Disease Relevance 1.19 Pain Relevance 0
Using a proteomic approach, You et al. found that the levels of ferritin light chain protein were significantly increased in atherosclerotic coronary arteries [48].
Gene_expression (levels) of chain protein associated with atherosclerosis
19) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736586 Disease Relevance 1.48 Pain Relevance 0.14

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