INT89546

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Context Info
Confidence 0.76
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.49
Pain Relevance 5.08

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mitochondrion (NEFH) cell death (NEFH) molecular_function (NEFH)
Anatomy Link Frequency
brains 3
lamina 2
optic nerves 1
cortex 1
NEFH (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 66 99.84 Very High Very High Very High
addiction 12 96.24 Very High Very High Very High
methadone 6 89.12 High High
opiate 6 87.92 High High
anesthesia 15 5.00 Very Low Very Low Very Low
Central nervous system 12 5.00 Very Low Very Low Very Low
ketamine 12 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glaucoma 273 97.24 Very High Very High Very High
Opiate Addiction 12 96.52 Very High Very High Very High
Overdose 6 88.28 High High
Leber Hereditary Optic Atrophy 48 88.20 High High
Frailty 6 82.72 Quite High
Syndrome 6 81.72 Quite High
Congenital Anomalies 7 81.56 Quite High
Sprains And Strains 6 79.76 Quite High
Ganglion Cysts 74 38.64 Quite Low
Eye Disease 4 33.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, increased levels of phosphorylated NF-H (58-41%) and NF-M (56-28%) were found in the same brains of opioid addicts.
Phosphorylation (phosphorylated) of NF-H in brains associated with opioid
1) Confidence 0.76 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.23 Pain Relevance 0.86
In the same brains of opioid addicts, the levels of protein phosphatase of the type 2A were found unchanged, which indicated that the hyperphosphorylation of NF-H is not the result of a reduced dephosphorylation process.
Phosphorylation (hyperphosphorylation) of NF-H in brains associated with opioid
2) Confidence 0.76 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.18 Pain Relevance 0.98
These marked reductions in total NF proteins and the aberrant hyperphosphorylation of NF-H in brains of opioid addicts may play a significant role in the cellular mechanisms of opioid addiction.
Phosphorylation (hyperphosphorylation) of NF-H in brains associated with addiction and opioid
3) Confidence 0.76 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.10 Pain Relevance 0.69
The ratio of phosphorylated to nonphosphorylated NF-H in opioid addicts (3.4) was greater than that in control subjects (1.6).
Phosphorylation (phosphorylated) of NF-H associated with opioid
4) Confidence 0.76 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.21 Pain Relevance 0.85
Decreased levels of nonphosphorylated NF-H (42-32%), NF-M (14-9%) and NF-L (30-29%) were found in the prefrontal cortex of opioid addicts compared with sex, age, and postmortem delay-matched controls.
Phosphorylation (nonphosphorylated) of NF-H in cortex associated with opioid
5) Confidence 0.75 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.25 Pain Relevance 0.85
The ratio of phosphorylated to nonphosphorylated NF-H in opioid addicts (3.4) was greater than that in control subjects (1.6).
Phosphorylation (nonphosphorylated) of NF-H associated with opioid
6) Confidence 0.58 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.21 Pain Relevance 0.85
Staining with an antibody that recognizes predominantly phosphorylated NEFH revealed presumptive growth cone-like structures in the post laminar optic nerves of monkeys with experimental glaucoma, which also were positive for GAP43 (Figure 2C), whereas these structures were absent in control monkeys.
Phosphorylation (phosphorylated) of NEFH in optic nerves associated with glaucoma
7) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.78 Pain Relevance 0
NEFH immunohistochemistry with an antibody that recognizes phosphorylated and non-phosphorylated NEFH shows axons in the normal sample traversing through the lamina cribrosa in well-organized bundles (Figure 2A), while the axons in ExpG were disorganized with an abnormal axonal morphology (Figure 2B).
Phosphorylation (phosphorylated) of NEFH in lamina associated with glaucoma
8) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.65 Pain Relevance 0
NEFH immunohistochemistry with an antibody that recognizes phosphorylated and non-phosphorylated NEFH shows axons in the normal sample traversing through the lamina cribrosa in well-organized bundles (Figure 2A), while the axons in ExpG were disorganized with an abnormal axonal morphology (Figure 2B).
Phosphorylation (phosphorylated) of NEFH in lamina associated with glaucoma
9) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.65 Pain Relevance 0
They are released into the bloodstream with axonal disruption, and the heavily phosphorylated axonal form of NF-H, pNF-H, has a collection of unusual properties that render it resistant to proteases and relatively easy to detect with ELISA and other antibody-based assays.
Phosphorylation (phosphorylated) of NF-H
10) Confidence 0.09 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 0.23 Pain Relevance 0

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