INT89549

Context Info Confidence 0.43 First Reported 2000 Last Reported 2008 Negated 0 Speculated 1 Reported most in Body Documents 2 Total Number 3 Disease Relevance 1.42 Pain Relevance 0.86

mitochondrion (NEFH) cell death (NEFH) molecular_function (NEFH)

Anatomy Link Frequency brains 1 optic nerves 1 NEFH (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 11 97.56 methadone 1 81.36 opiate 1 80.16 addiction 2 74.60 anesthesia 10 5.00 Central nervous system 8 5.00 ketamine 8 5.00 imagery 4 5.00 cytokine 2 5.00 Inflammation 2 5.00

Disease Link Frequency Relevance Heat Glaucoma 182 98.88 Frailty 4 88.76 Syndrome 4 87.76 Sprains And Strains 4 85.80 Overdose 1 80.52 Opiate Addiction 2 74.60 Congenital Anomalies 1 73.80 Ganglion Cysts 46 72.64 Familial Adenomatous Polyposis 8 41.16 Ocular Hypertension 36 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, increased levels of phosphorylated NF-H (58-41%) and NF-M (56-28%) were found in the same brains of opioid addicts.

Positive_regulation (increased) of NF-H in brains associated with opioid

1) Confidence 0.43 Published 2000 Journal J. Neurosci. Res. Section Abstract Doc Link 10900081 Disease Relevance 0.23 Pain Relevance 0.86

The higher NEFH increase in sample 529 may be due to retinal contamination or to higher IOP exposure in that spontaneous glaucoma compared to the laser treated samples.

Positive_regulation (increase) of NEFH associated with glaucoma

2) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.60 Pain Relevance 0

Two NEFH antibodies were used to examine the localization of upregulated NEFH in the axons of optic nerves of healthy and experimental glaucoma monkeys.

Spec (examine) Positive_regulation (upregulated) of NEFH in optic nerves associated with glaucoma

3) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567987 Disease Relevance 0.59 Pain Relevance 0

General Comments

This test has worked.