INT89582

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.85
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PKP1) cell adhesion (PKP1) nucleolus (PKP1)
plasma membrane (PKP1) nucleus (PKP1) signal transducer activity (PKP1)
Anatomy Link Frequency
plasma 1
filaments 1
PKP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 40.56 Quite Low
Kinase C 39 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
imagery 16 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
corticosteroid 7 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 5 95.80 Very High Very High Very High
Disease 95 83.28 Quite High
Adhesions 154 72.52 Quite High
Heart Defects 13 70.16 Quite High
Death 12 69.32 Quite High
Bites And Stings 1 55.36 Quite High
Infection 2 53.12 Quite High
Arrhythmogenic Right Ventricular Dysplasia 14 50.00 Quite Low
Sudden Death 22 48.96 Quite Low
Fever 4 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the evaluation of people's knowledge and practice (PKP) is of great importance to improve integrated control measures.
PKP Binding (evaluation) of
1) Confidence 0.36 Published 2000 Journal J. Am. Mosq. Control Assoc. Section Abstract Doc Link 10901634 Disease Relevance 0.43 Pain Relevance 0
Plakophilin 1 recruits desmosomal components to the cell membrane, increases size and number of desmosomes and therefore seems to be a scaffolding protein, which induces desmosome assembly (Hatzfeld et al. 2000; Kowalczyk et al. 1999; Wahl 2005).
Plakophilin 1 Binding (seems) of
2) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.14 Pain Relevance 0
It has been demonstrated that desmosome formation is mediated by the aminoterminal domain, whereas recruitment of plakophilin 1 itself to the plasma membrane is dependent on the carboxyterminal region (Sobolik-Delmaire et al. 2006).
plakophilin 1 Binding (recruitment) of in plasma
3) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
Plakophilin 1 associates with actin filaments at cell borders and has been reported to interact with a GTP exchange factor (GEF) for Rho and thereby could regulate activity of Rho GTPases similar to the closely related p120-catenin, which is known to inhibit Rho A and to activate Rac 1 and Cdc42 (Anastasiadis and Reynolds 2001; Hatzfeld 2007).
Plakophilin 1 Binding (associates) of in filaments
4) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
Binding sites for both plakoglobin and plakophilin are situated in the N-terminal domain of desmoplakin.
plakophilin Binding (Binding) of
5) Confidence 0.01 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2222049 Disease Relevance 0.28 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox