INT89583

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.16
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hepatocytes 1
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Lasting pain 5 97.88 Very High Very High Very High
depression 6 93.80 High High
Paracetamol 4 85.76 High High
antinociception 10 82.96 Quite High
adenocard 24 81.04 Quite High
agonist 3 71.28 Quite High
IPN 6 69.04 Quite High
Antinociceptive 22 67.12 Quite High
Spinal cord 4 17.00 Low Low
backache 1 10.56 Low Low
Disease Link Frequency Relevance Heat
Nephrotoxicity 2 100.00 Very High Very High Very High
Cognitive Disorder 80 98.52 Very High Very High Very High
Pain 9 97.88 Very High Very High Very High
Tics 3 95.04 Very High Very High Very High
Depression 6 93.80 High High
Dementia 12 85.64 High High
Inflammatory Pain 6 69.04 Quite High
Disease 1 61.76 Quite High
Aging 2 49.76 Quite Low
Paralysis 4 21.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it might be possible to further optimize PAP stability and kinetic parameters for therapeutic purposes, using site-directed mutagenesis and the PAP three-dimensional structure as a guide [9], [14], [15], [47].


Protein_catabolism (stability) of PAP
1) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617779 Disease Relevance 0.28 Pain Relevance 0.70
In conclusion, we found that PAP was metabolized in hepatocytes predominantly to PAP-GSH conjugates and PAP-N-acetylcysteine conjugates in sufficient quantities to account for the nephrotoxicity of PAP.
Protein_catabolism (nephrotoxicity) of PAP in hepatocytes associated with nephrotoxicity
2) Confidence 0.36 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10901695 Disease Relevance 0.10 Pain Relevance 0.34
PAP: placebo activity program
Protein_catabolism (program) of PAP
3) Confidence 0.10 Published 2005 Journal BMC Geriatr Section Body Doc Link PMC1361795 Disease Relevance 0.78 Pain Relevance 0.05

General Comments

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