INT89589

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Context Info
Confidence 0.40
First Reported 2000
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 4.62
Pain Relevance 7.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
plasma 1
external 1
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 26 99.98 Very High Very High Very High
Inflammation 105 99.38 Very High Very High Very High
Enkephalin 73 98.84 Very High Very High Very High
cytokine 12 98.30 Very High Very High Very High
isoflurane 8 97.76 Very High Very High Very High
Inflammatory mediators 5 95.40 Very High Very High Very High
Opioid 17 93.48 High High
Analgesic 14 92.16 High High
Potency 5 90.68 High High
opioid receptor 20 89.76 High High
Disease Link Frequency Relevance Heat
Arthritis 10 99.84 Very High Very High Very High
INFLAMMATION 115 99.38 Very High Very High Very High
Necrosis 8 99.34 Very High Very High Very High
Cancer 8 99.16 Very High Very High Very High
Cold Sores 218 99.06 Very High Very High Very High
Repression 4 96.88 Very High Very High Very High
Endotoxemia 2 92.60 High High
Stress 6 92.08 High High
Ulcers 2 91.52 High High
Hepatocellular Cancer 1 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The concentrations of the cytokines interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha and the chemokines CCL5 and CCL2 were significantly decreased in arthritic rats treated with atorvastatin.
Negative_regulation (decreased) of CCL5 associated with chemokine, necrosis, cancer, arthritis and cytokine
1) Confidence 0.40 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15970284 Disease Relevance 0.77 Pain Relevance 0.44
DAMGO pretreatment enhanced phosphorylation of the chemokine CCR5 receptor and reduced RANTES (CCL5)-promoted [35S]GTP gamma S binding.
Negative_regulation (reduced) of RANTES associated with chemokine
2) Confidence 0.38 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14729105 Disease Relevance 0 Pain Relevance 0.57
Levels of RANTES were similarly reduced by 43.1% (n.s.).
Negative_regulation (reduced) of RANTES
3) Confidence 0.36 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 16023603 Disease Relevance 0.41 Pain Relevance 0.75
The plasma level of CCL5 was increased in MS patients before treatment and was also significantly decreased in the treatment of MS with MP and MTX.
Negative_regulation (decreased) of CCL5 in plasma
4) Confidence 0.34 Published 2008 Journal Acta Neurol. Scand. Section Body Doc Link 18336625 Disease Relevance 0.08 Pain Relevance 0
The improved histological findings for pancreatic tissues after HSV-ENK in the present study were coincident with decreased RANTES and COX-2 and increased met-enkephalin staining.
Negative_regulation (decreased) of RANTES associated with cold sores and enkephalin
5) Confidence 0.26 Published 2008 Journal Mol Pain Section Body Doc Link PMC2292157 Disease Relevance 0.89 Pain Relevance 1.87
The increase in efficacy during inflammation has been shown to be true for reduction of RANTES in particular [69,105].
Negative_regulation (reduction) of RANTES associated with inflammation
6) Confidence 0.23 Published 2008 Journal Mol Pain Section Body Doc Link PMC2292157 Disease Relevance 0.85 Pain Relevance 1.69
We found an inverse correlation between constitutive RANTES production and chemotactic responsiveness toward external RANTES, suggesting a possible functional down-modulation of the RANTES receptors, CC chemokine receptor 1 and CC chemokine receptor 5, during culture.
Spec (possible) Negative_regulation (down-modulation) of RANTES in external associated with chemokine
7) Confidence 0.20 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11710916 Disease Relevance 0.12 Pain Relevance 0.48
Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein.
Negative_regulation (prevented) of CCL5 associated with chemokine
8) Confidence 0.15 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.88
Following TAH, the serum levels of RANTES were reduced in the untreated patients, but were significantly higher in the patients treated with LOR.
Negative_regulation (reduced) of RANTES
9) Confidence 0.06 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19966527 Disease Relevance 0.47 Pain Relevance 0.25
The same rank order was found for inhibition of RANTES release.
Negative_regulation (inhibition) of RANTES
10) Confidence 0.03 Published 2000 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10903220 Disease Relevance 0.46 Pain Relevance 0.15
In the LCP subgroup, serum IL-15, GM-CSF, and RANTES levels were reduced significantly, while serum IL-10 levels increased significantly only in the responder group after treatment.
Negative_regulation (reduced) of RANTES
11) Confidence 0.02 Published 2001 Journal J Clin Apher Section Abstract Doc Link 11746532 Disease Relevance 0.51 Pain Relevance 0.31

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