INT8959

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Context Info
Confidence 0.40
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 31.38
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gnb5) plasma membrane (Gnb5) nucleus (Gnb5)
signal transducer activity (Gnb5)
Anatomy Link Frequency
visceral 1
brain 1
bowel 1
body 1
Gnb5 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 274 99.98 Very High Very High Very High
Neuritis 54 99.20 Very High Very High Very High
Inflammation 131 98.70 Very High Very High Very High
Demyelination 50 98.52 Very High Very High Very High
backache 12 98.16 Very High Very High Very High
Visceral pain 2 95.84 Very High Very High Very High
Intracerebroventricular 1 95.36 Very High Very High Very High
Peripheral nerve injury 2 94.00 High High
Peripheral nervous system 35 93.12 High High
cytokine 24 92.24 High High
Disease Link Frequency Relevance Heat
Syndrome 455 100.00 Very High Very High Very High
Infection 117 100.00 Very High Very High Very High
Mycobacterial Infection 65 100.00 Very High Very High Very High
Pain 245 99.98 Very High Very High Very High
Toxicity 7 99.32 Very High Very High Very High
Togavirus Infection 2 99.30 Very High Very High Very High
Inflammatory Bowel Disease 88 99.28 Very High Very High Very High
Experimental Autoimmune Neuritis 41 99.20 Very High Very High Very High
Mumps 2 99.04 Very High Very High Very High
Lymph Node Tuberculosis 24 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11), and its binding protein Gbeta5, are found in neural structures of mouse brain.
Gbeta5 Binding (binding) of in brain
1) Confidence 0.40 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0 Pain Relevance 0.66
Because it is likely that different pathophysiological mechanisms are related to these symptoms, a more detailed classification of different pain symptoms associated with GBS can be of help to study the effect of drugs.
GBS Binding (associated) of associated with pain and syndrome
2) Confidence 0.38 Published 2007 Journal J Neurol Section Body Doc Link PMC2778673 Disease Relevance 1.56 Pain Relevance 0.98
Different symptoms of pain associated with GBS have been distinguished: par-/dysaesthesiae, backache / root pain, meningism, muscle pain, joint pain, visceral pain and other types [12].
GBS Binding (associated) of in visceral associated with pain, arthralgia, visceral pain, syndrome, meningism, myalgia and backache
3) Confidence 0.28 Published 2007 Journal J Neurol Section Body Doc Link PMC2778673 Disease Relevance 2.60 Pain Relevance 1.58
However, association of GBS and TB has been reported [7-11], moreover, in a recent report, Soysal y Cols., found 2 out of 104 cases of GBS to be associated with TB [12].
GBS Binding (association) of associated with mycobacterial infection and syndrome
4) Confidence 0.17 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2912254 Disease Relevance 2.55 Pain Relevance 0.16
Patient 1 is a 56-year-old female diagnosed with GBS one week after onset of rapidly progressive total body weakness.
GBS Binding (diagnosed) of in body associated with syndrome
5) Confidence 0.17 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413194 Disease Relevance 0.55 Pain Relevance 0.04
We report an unusual case of GBS with a multiple association.
GBS Binding (association) of associated with syndrome
6) Confidence 0.14 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2912254 Disease Relevance 2.45 Pain Relevance 0.10
Guillain-Barré syndrome, tuberculosis and inflammatory bowel disease: a multiple association

Guillain-Barré syndrome (GBS) has been associated with both infective or non-infective aetiologies.

GBS Binding (associated) of in bowel associated with mycobacterial infection, inflammation and syndrome
7) Confidence 0.13 Published 2010 Journal Int Arch Med Section Title Doc Link PMC2912254 Disease Relevance 1.22 Pain Relevance 0.14
Descriptions of association between TB and GBS have been reported but this unique disorder combination has seldom been described.
GBS Binding (association) of associated with mycobacterial infection and syndrome
8) Confidence 0.13 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2912254 Disease Relevance 2.26 Pain Relevance 0.07
Some HS C. jejuni serotypes such as HS O:19 are usually associated with GBS.
GBS Binding (associated) of associated with syndrome
9) Confidence 0.04 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2852392 Disease Relevance 2.22 Pain Relevance 0
Studies have shown that lipopolysaccharides extracted from C. jejuni associated with GBS mimic human gangliosides in their structure [2].
GBS Binding (associated) of associated with syndrome
10) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2852392 Disease Relevance 2.74 Pain Relevance 0.06
That study established an epidemiological association between C. jejuni infection and GBS.
GBS Binding (association) of associated with syndrome and infection
11) Confidence 0.02 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010740 Disease Relevance 1.79 Pain Relevance 0.11
In view of the reported association of GBS with a number of infectious agents we have investigated whether "molecular mimicry" may occur between microbial antigens and the P0 protein that could possibly trigger a similar pathogenic autoimmune response in man.
GBS Binding (association) of
12) Confidence 0.02 Published 1992 Journal Neurochem. Res. Section Abstract Doc Link 1383842 Disease Relevance 1.03 Pain Relevance 0.28
In summary, GBS is the first true model of molecular mimicry having fulfilled all four criteria as follows: (i) establishment of an epidemiological association between GBS and C. jejuni infection by a prospective case-control study [7], (ii) identification of autoantibodies against GM1 and GD1a gangliosides in patients with AMAN subsequent to C. jejuni enteritis [11, 12], (iii) identification of molecular mimicry between GM1 or GD1a and LOS of C. jejuni isolated from AMAN [13, 14], and (iv) reproduction of the AMAN models by active immunization of rabbits with GM1 or the C. jejuni LOS [16, 19] as well as by passive transfer of anti-GD1a antibodies in mice [20].
GBS Binding (association) of associated with neuropathy, enteritis, syndrome, immunization and infection
13) Confidence 0.02 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3010740 Disease Relevance 1.26 Pain Relevance 0.05
In contrast, both binding and intracellular survival of GBS were not affected in Fc?
GBS Binding (binding) of
14) Confidence 0.02 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2987830 Disease Relevance 0.08 Pain Relevance 0
Reflexes are usually lost early in the illness, although GBS can be associated with retained reflexes or even brisk reflexes [76].
GBS Binding (associated) of associated with syndrome
15) Confidence 0.01 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923368 Disease Relevance 2.09 Pain Relevance 0.40
A specific association with GBS was first suggested in the 1980s.
GBS Binding (association) of associated with syndrome
16) Confidence 0.01 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2629480 Disease Relevance 1.68 Pain Relevance 0.21
Moreover, GBS has been associated with a panel of human herpesviruses, namely Varicella-zoster virus [82-84], cytomegalovirus [84-86], Herpes simplex virus [84] and more frequently Epstein Barr virus [84-86].
GBS Binding (associated) of associated with herpes simplex virus, syndrome, herpes zoster and cytomegalovirus infection
17) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2825213 Disease Relevance 2.41 Pain Relevance 0.15
Anteceding immunizations with vaccines against influenza, hepatitis, measles, mumps, and rubella and others infrequently have been associated with GBS [77,87-89].
GBS Binding (associated) of associated with syndrome, mumps, measles, influenza virus infection, togavirus infection and hepatitis
18) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2825213 Disease Relevance 2.80 Pain Relevance 0.11

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