INT89590

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Context Info
Confidence 0.36
First Reported 2000
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.97
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ccl5) aging (Ccl5) extracellular region (Ccl5)
cell-cell signaling (Ccl5) cytoplasm (Ccl5)
Anatomy Link Frequency
lung 4
pancreas 2
Ccl5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 21 100.00 Very High Very High Very High
Inflammatory mediators 7 100.00 Very High Very High Very High
fluoxetine 94 99.98 Very High Very High Very High
antidepressant 90 99.98 Very High Very High Very High
Desipramine 98 99.68 Very High Very High Very High
Inflammation 145 98.28 Very High Very High Very High
isoflurane 8 97.76 Very High Very High Very High
chemokine 14 97.68 Very High Very High Very High
cINOD 5 87.96 High High
Raphe 2 87.24 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 159 100.00 Very High Very High Very High
Cold Sores 109 99.20 Very High Very High Very High
Repression 6 97.68 Very High Very High Very High
Endotoxemia 4 93.00 High High
Pancreatitis 56 88.88 High High
Asthma 33 88.56 High High
Urological Neuroanatomy 4 86.56 High High
Immune System Diseases 1 82.40 Quite High
Myoma 2 78.08 Quite High
Pneumonia 6 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Levels of RANTES were similarly reduced by 43.1% (n.s.).
Negative_regulation (reduced) of Gene_expression (Levels) of RANTES
1) Confidence 0.36 Published 2005 Journal Int. Immunopharmacol. Section Abstract Doc Link 16023603 Disease Relevance 0.41 Pain Relevance 0.75
Decreased RANTES expression in the pancreas of HSV-ENK-treated animals
Negative_regulation (Decreased) of Gene_expression (expression) of RANTES in pancreas associated with cold sores
2) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2292157 Disease Relevance 1.26 Pain Relevance 0.30
Similarly, pretreatment with cycloheximide prevented CCL5 or CXCR4 mRNA expression, consistent with the observation that DAMGO induction of chemokine and chemokine receptor expression requires newly synthesized TGF-beta1 protein.
Negative_regulation (prevented) of Gene_expression (expression) of CCL5 associated with chemokine
3) Confidence 0.15 Published 2008 Journal J. Leukoc. Biol. Section Abstract Doc Link 18252865 Disease Relevance 0 Pain Relevance 0.88
Yet, in cultured lung epithelial cells, both antidepressants inhibited with similar efficacy the production of RANTES, a known chemotactic for eosinophils.
Negative_regulation (inhibited) of Gene_expression (production) of RANTES in lung associated with antidepressant
4) Confidence 0.10 Published 2007 Journal Respir Res Section Body Doc Link PMC1876225 Disease Relevance 0.61 Pain Relevance 1.08
Desipramine and fluoxetine inhibit expression of RANTES in lung A549 epithelial cells
Negative_regulation (inhibit) of Gene_expression (expression) of RANTES in lung associated with desipramine and fluoxetine
5) Confidence 0.09 Published 2007 Journal Respir Res Section Body Doc Link PMC1876225 Disease Relevance 0.43 Pain Relevance 0.98
In conclusion, preoperatively intravenous injection of LOR may effectively restrain the decreased serum levels of RANTES and the increased expression of MCP-1 and SDF-1alpha in TAH patients.
Negative_regulation (decreased) of Gene_expression (levels) of RANTES
6) Confidence 0.06 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19966527 Disease Relevance 0.26 Pain Relevance 0.21
Following TAH, the serum levels of RANTES were reduced in the untreated patients, but were significantly higher in the patients treated with LOR.
Negative_regulation (reduced) of Gene_expression (levels) of RANTES
7) Confidence 0.06 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19966527 Disease Relevance 0.48 Pain Relevance 0.25
Through trans-repression, they inhibit the transcription factors nuclear factor kappa B (NF-kappaB) and activator protein-1 (AP-1), thereby decreasing the expression of many genes encoding inflammatory mediators such as the cytokine RANTES.
Negative_regulation (decreasing) of Gene_expression (expression) of RANTES associated with inflammatory mediators, repression and cytokine
8) Confidence 0.04 Published 2000 Journal Am. J. Respir. Crit. Care Med. Section Abstract Doc Link 10903220 Disease Relevance 0.52 Pain Relevance 0.22

General Comments

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