INT8960

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 9.20
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (SDHB) mitochondrion (SDHB) small molecule metabolic process (SDHB)
oxidoreductase activity (SDHB)
Anatomy Link Frequency
spinal 1
germline 1
anterior cerebral artery 1
SDHB (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 132 100.00 Very High Very High Very High
headache 5 99.76 Very High Very High Very High
backache 1 96.76 Very High Very High Very High
imagery 47 92.64 High High
epidural 1 89.68 High High
anesthesia 1 78.88 Quite High
Catecholamine 19 75.36 Quite High
medulla 4 62.48 Quite High
Neuropeptide 2 50.32 Quite High
Enkephalin 3 27.04 Quite Low
Disease Link Frequency Relevance Heat
Paraganglioma 103 100.00 Very High Very High Very High
Disease 51 100.00 Very High Very High Very High
Cv General 4 Under Development 21 100.00 Very High Very High Very High
Head Trauma 14 100.00 Very High Very High Very High
Spinal Subdural Hematoma 6 100.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 5 100.00 Very High Very High Very High
Watson Syndrome 4 100.00 Very High Very High Very High
Von Hippel-lindau Syndrome 3 100.00 Very High Very High Very High
Syndrome 58 99.96 Very High Very High Very High
Intracranial Hypotension 5 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So far, germline mutations in five genes have been identified to be responsible for familial PHEOs: the von Hippel-Lindau gene, which causes von Hippel-Lindau syndrome, the RET gene leading to multiple endocrine neoplasia type 2, the neurofibromatosis type 1 gene, which is associated with von Recklinghausen's disease and the genes encoding the B and D subunits of mitochondrial succinate dehydrogenase (SDHB, SDHD), which are associated with familial paragangliomas and PHEOs.
SDHB Binding (associated) of in germline associated with multiple endocrine neoplasia type 2a, syndrome, paraganglioma, disease and watson syndrome
1) Confidence 0.36 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 17119341 Disease Relevance 1.24 Pain Relevance 0.15
Four patients presented with rare spinal subdural hematoma (SDH) occurring after intracranial aneurysm surgery and manifesting as postoperative back pain.
SDH Binding (presented) of in spinal associated with cerebral aneurysm, spinal subdural hematoma and backache
2) Confidence 0.36 Published 2007 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 17245010 Disease Relevance 0.90 Pain Relevance 0.20
Paragangliomas may be hereditary and can be associated with familial paraganglioma, neurofibromatosis type 1, von Hippel-Lindau disease, the Carney triad, multiple endocrine neoplasia type 2, and mutations of the succinate dehydrogenase genes (SDHB, SDHC, and SDHD) [1].
SDHB Binding (associated) of associated with multiple endocrine neoplasia type 2a, von hippel-lindau syndrome, paraganglioma and watson syndrome
3) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 1.06 Pain Relevance 0.08
A ruptured giant aneurysm of the azygos anterior cerebral artery (ACA) associated with an acute subdural hematoma (SDH) occurred in a 67-year-old male with two episodes of sudden severe headache and transient loss of consciousness.
SDH Binding (associated) of in anterior cerebral artery associated with head trauma, unconsciousness, aneurism and headache
4) Confidence 0.27 Published 1992 Journal Neurol. Med. Chir. (Tokyo) Section Abstract Doc Link 1383859 Disease Relevance 0.85 Pain Relevance 0.10
PCR products were digested and visualized with ethidium bromide on agarose gels in the concentration ranges 2.0 to 3.0%

RT-PCR analysis of splicing of SDHB (c.423+1G>A)

SDHB Binding (splicing) of
5) Confidence 0.18 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1343542 Disease Relevance 0.20 Pain Relevance 0
In patients with familial pheochromocytoma screening for gene mutations in the RET, VHL, SDHB and SDHD gene is recommended since different familial syndromes can be revealed.
SDHB Binding (recommended) of associated with syndrome and pheochromocytoma
6) Confidence 0.11 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2169240 Disease Relevance 1.11 Pain Relevance 0
SDH was associated with headache worsening or neurological deficits.
SDH Binding (associated) of associated with head trauma and headache
7) Confidence 0.06 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17257233 Disease Relevance 1.43 Pain Relevance 0.28
SDH, SC, AWH and TKS drafted the manuscript and all authors approved the final manuscript



SDH Binding (drafted) of
8) Confidence 0.03 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1236968 Disease Relevance 0.37 Pain Relevance 0
In recent years, SDH has been recognized more often mainly because neuroimaging is now also performed routinely in infants not presenting with clinical symptoms [1].
SDH Binding (recognized) of associated with cva
9) Confidence 0.01 Published 2010 Journal Neuroradiology Section Body Doc Link PMC2872016 Disease Relevance 2.03 Pain Relevance 0.88

General Comments

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