INT89603

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Context Info
Confidence 0.30
First Reported 2000
Last Reported 2010
Negated 0
Speculated 8
Reported most in Abstract
Documents 11
Total Number 18
Disease Relevance 10.59
Pain Relevance 6.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
colon 2
bladder 2
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 47 100.00 Very High Very High Very High
COX2 12 100.00 Very High Very High Very High
cINOD 74 99.58 Very High Very High Very High
Inflammation 77 99.44 Very High Very High Very High
Analgesic 14 99.40 Very High Very High Very High
aspirin 23 98.88 Very High Very High Very High
withdrawal 22 97.36 Very High Very High Very High
alcohol 18 95.92 Very High Very High Very High
diclofenac 29 93.48 High High
gABA 16 92.16 High High
Disease Link Frequency Relevance Heat
Cancer 147 100.00 Very High Very High Very High
Pancreatic Cancer 84 99.84 Very High Very High Very High
Testicular Cancer 1 99.50 Very High Very High Very High
INFLAMMATION 97 99.46 Very High Very High Very High
Influenza Virus Infection 74 99.44 Very High Very High Very High
Reprotox - General 1 3 99.06 Very High Very High Very High
Targeted Disruption 34 99.02 Very High Very High Very High
Colon Cancer 49 98.88 Very High Very High Very High
Bladder Cancer 1 98.72 Very High Very High Very High
Apoptosis 47 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that inhibition of cyclooxygenase (COX)-1 is the major action of aspirin involved in its analgesic and antipyretic effects, and inhibition of COX-2 is responsible for its anti-inflammatory action.
Regulation (responsible) of Negative_regulation (inhibition) of COX associated with aspirin, inflammation and analgesic
1) Confidence 0.30 Published 2003 Journal Thromb. Res. Section Abstract Doc Link 14592546 Disease Relevance 0.45 Pain Relevance 1.02
A TRAMP/COX-2 knockout mouse model was also generated to determine the effects of the loss of the COX-2 gene on prostate tumorigenesis in TRAMP mice.
Regulation (effects) of Negative_regulation (loss) of COX associated with targeted disruption
2) Confidence 0.27 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 17942462 Disease Relevance 0.75 Pain Relevance 0.18
The effects of selective pharmacologic inhibitiors of COX-1 or COX 2 in this model have not been investigated.
Spec (investigated) Regulation (effects) of Negative_regulation (inhibitiors) of COX associated with cox2
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 1.30 Pain Relevance 0.57
The effects of selective pharmacologic inhibitiors of COX-1 or COX 2 in this model have not been investigated.
Spec (investigated) Regulation (effects) of Negative_regulation (inhibitiors) of COX associated with cox2
4) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2904706 Disease Relevance 1.31 Pain Relevance 0.57
In contrast, gamma-resorcylic acid (2,6-dihydroxybenzoic acid) as well as unconjugated coenzyme A failed to affect prostanoid synthesis, implying that the para-substitution of hydroxy groups and the activated coenzyme A thioester are important for COX-2 inhibition.
Regulation (important) of Negative_regulation (inhibition) of COX
5) Confidence 0.22 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 10903918 Disease Relevance 0.06 Pain Relevance 0.20
Our findings suggest that ablation of COX activity alters the transcription of many genes, including those involved in ?
Regulation (alters) of Negative_regulation (ablation) of COX
6) Confidence 0.19 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.25 Pain Relevance 0.29
In the present study we examined the effect of nimesulide (a preferential COX-2 inhibitor), rofecoxib (a highly selective COX-2 inhibitor) or naproxen (a non-selective COX-inhibitor displaying high affinity towards the COX-1 isoenzyme) on alcohol-induced withdrawal symptoms.
Spec (examined) Regulation (effect) of Negative_regulation (inhibitor) of COX associated with cox-2 inhibitor, withdrawal and alcohol
7) Confidence 0.17 Published 2005 Journal Addict Biol Section Abstract Doc Link 16318954 Disease Relevance 0.09 Pain Relevance 0.33
In the present study we examined the effect of nimesulide (a preferential COX-2 inhibitor), rofecoxib (a highly selective COX-2 inhibitor) or naproxen (a non-selective COX-inhibitor displaying high affinity towards the COX-1 isoenzyme) on alcohol-induced withdrawal symptoms.
Spec (examined) Regulation (effect) of Negative_regulation (inhibitor) of COX associated with cox-2 inhibitor, withdrawal and alcohol
8) Confidence 0.17 Published 2005 Journal Addict Biol Section Abstract Doc Link 16318954 Disease Relevance 0.10 Pain Relevance 0.33
Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes.
Regulation (effect) of Negative_regulation (inhibitors) of COX associated with withdrawal
9) Confidence 0.17 Published 2005 Journal Addict Biol Section Title Doc Link 16318954 Disease Relevance 0.08 Pain Relevance 0.34
The purpose of the present study was to examine the effect of deficiency of COX-1 or COX-2 on the host response to influenza.
Spec (examine) Regulation (effect) of Spec (examine) Negative_regulation (deficiency) of COX associated with influenza virus infection
10) Confidence 0.13 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16272346 Disease Relevance 1.00 Pain Relevance 0.37
The purpose of the present study was to examine the effect of deficiency of COX-1 or COX-2 on the host response to influenza.
Spec (examine) Regulation (effect) of Spec (examine) Negative_regulation (deficiency) of COX associated with influenza virus infection
11) Confidence 0.13 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16272346 Disease Relevance 1.01 Pain Relevance 0.37
COX-2 inhibitors, which belong to the family of nonsteroidal anti-inflammatory drugs, are believed to be effective in many biological activities such as tumor chemoprevention because of their inhibition of COX-2.
Regulation (effective) of Negative_regulation (inhibition) of COX associated with inflammation, cancer, cinod and cox-2 inhibitor
12) Confidence 0.12 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12433932 Disease Relevance 0.20 Pain Relevance 0.19
To address this question, we examined the effects of COX-2 inhibition on prostate tumorigenesis in the transgenic adenocarcinoma mouse prostate (TRAMP) model.
Spec (examined) Regulation (effects) of Spec (examined) Negative_regulation (inhibition) of COX associated with adenocarcinoma and targeted disruption
13) Confidence 0.12 Published 2008 Journal Carcinogenesis Section Abstract Doc Link 17942462 Disease Relevance 0.64 Pain Relevance 0.13
How might carboxylate conversion into amide affect the COX inhibition?
Regulation (affect) of Negative_regulation (inhibition) of COX
14) Confidence 0.11 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2131780 Disease Relevance 0 Pain Relevance 0.24
In this review, we demonstrated the expression of COX-2 in urological cancer(renal cell carcinoma, bladder tumor, prostate cancer, and testicular tumor) tissues as well as the effects of COX inhibitors.
Regulation (effects) of Negative_regulation (inhibitors) of COX in bladder associated with bladder cancer, renal cancer, testicular cancer, reprotox - general 1 and urinary tract cancer
15) Confidence 0.09 Published 2005 Journal Nippon Rinsho Section Abstract Doc Link 16218400 Disease Relevance 0.73 Pain Relevance 0.33
The aim of the present study was to investigate the effects of COX-2 inhibitor and drugs blocking the biological activities of angiotensin II [angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs)] on IGF-IR expression and tumor growth in vivo.
Spec (investigate) Regulation (effects) of Spec (investigate) Negative_regulation (inhibitor) of COX associated with cancer and cox-2 inhibitor
16) Confidence 0.08 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14583467 Disease Relevance 0.49 Pain Relevance 0.16
Effects of COX and LOX inhibition on pancreatic cancer growth and apoptosis: In vitro and in vivo studies
Regulation (Effects) of Negative_regulation (inhibition) of COX associated with pancreatic cancer and apoptosis
17) Confidence 0.05 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149414 Disease Relevance 1.28 Pain Relevance 0.13
Because COX-2 is responsible for the increased PGE2 production in cancer, the inhibition of COX-2 activity is critical for colon cancer chemoprevention.
Regulation (responsible) of Negative_regulation (inhibition) of COX in colon associated with cancer and colon cancer
18) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.86 Pain Relevance 0.54

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