INT89614

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 10.16
Pain Relevance 1.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (FABP3) cytoskeletal protein binding (FABP3) cytosol (FABP3)
Anatomy Link Frequency
plasma 2
heart 2
artery 1
chest 1
band 1
FABP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 145 99.36 Very High Very High Very High
Angina 201 98.88 Very High Very High Very High
cva 30 97.52 Very High Very High Very High
Inflammatory marker 11 87.44 High High
Inflammation 115 83.68 Quite High
Inflammatory response 7 69.76 Quite High
depression 4 12.20 Low Low
metalloproteinase 25 5.00 Very Low Very Low Very Low
cytokine 20 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 353 100.00 Very High Very High Very High
Acute Coronary Syndrome 368 99.92 Very High Very High Very High
Injury 80 99.92 Very High Very High Very High
Coronary Artery Disease 138 99.36 Very High Very High Very High
Cv Unclassified Under Development 89 99.28 Very High Very High Very High
Angina 202 98.88 Very High Very High Very High
Heart Rate Under Development 31 98.60 Very High Very High Very High
Death 113 98.36 Very High Very High Very High
Pulmonary Embolism 20 97.92 Very High Very High Very High
Necrosis 137 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using human heart-type fatty acid-binding protein (H-FABP) as an early cardiac marker to confirm or exclude a diagnosis of acute myocardial infarction (AMI) soon after admission requires a rapid assay system.
Positive_regulation (requires) of H-FABP in heart associated with myocardial infarction
1) Confidence 0.50 Published 2003 Journal J. Immunol. Methods Section Abstract Doc Link 12969550 Disease Relevance 0.20 Pain Relevance 0
Clinical evaluation of H-FABP in comparison with myoglobin and creatine kinase isoenzyme MB.
Positive_regulation (evaluation) of H-FABP
2) Confidence 0.49 Published 2000 Journal Clin. Chem. Lab. Med. Section Title Doc Link 10905760 Disease Relevance 0.62 Pain Relevance 0.05
The use of human heart-type fatty acid-binding protein as an early diagnostic biochemical marker of myocardial necrosis in patients with acute coronary syndrome, and its comparison with troponin-T and creatine kinase-myocardial band.
Positive_regulation (use) of heart-type fatty acid-binding protein in band associated with acute coronary syndrome and necrosis
3) Confidence 0.43 Published 2006 Journal Heart Vessels Section Title Doc Link 17151819 Disease Relevance 0.80 Pain Relevance 0.32
In a recent single-centered small study, it was observed that patients with elevated H-FABP on admission had a higher risk of developing major pulmonary embolism-related complications [84].
Positive_regulation (elevated) of H-FABP associated with pulmonary embolism and cva
4) Confidence 0.34 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.63 Pain Relevance 0.46
H-FABP is a very sensitive marker, which can be elevated in patients with ischemia or even congestive heart failure (19).
Positive_regulation (elevated) of H-FABP in heart associated with heart rate under development and ischemia
5) Confidence 0.29 Published 2011 Journal Journal of Korean Medical Science Section Body Doc Link PMC3012849 Disease Relevance 0.91 Pain Relevance 0.10
Elevated serum H-FABP is associated with an increased risk of death and major cardiac events in patients with acute coronary syndromes despite negative serum cTn and BNP [52].


Positive_regulation (Elevated) of H-FABP associated with acute coronary syndrome and death
6) Confidence 0.23 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.54 Pain Relevance 0.26
Increased plasma H-FABP concentration significantly correlate with cardiac events and mortality (Ishii J et al. 2003).
Positive_regulation (Increased) of H-FABP in plasma
7) Confidence 0.10 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.82 Pain Relevance 0.14
(O’Donoghue et al. 2006), have evaluated H-FABP, Troponin and BNP levels of 2287 patients with ACS from the OPUS-TIMI 16 trial and have found that elevation of H-FABP is associated with an increased risk of death and major cardiac events at 10 months of follow up, independently from other established clinical risk predictors and biomarkers.
Positive_regulation (elevation) of H-FABP associated with acute coronary syndrome and death
8) Confidence 0.10 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.76 Pain Relevance 0.07
Nakata et al. have shown that H-FABP has greater diagnostic value and sensitivity than cTnT, CKMB and myoglobin in patients with suspected ACS within 6 h from acute chest pain onset (Nakata T et al. 2003) and an early or sustained elevation in H-FABP could indicate unfavourable clinical outcome (Suzuki M et al. 2005), as confirmed by Nagahara (Nagahara D et al. 2006), too, who found a higher positive predictive value (84%–91%), a higher sensitivity (75%–77%) and a better negative predictive value (nearly 40%) for H-FABP vs cTnT, CK-MB and myoglobin.
Positive_regulation (elevation) of H-FABP in chest associated with acute coronary syndrome and angina
9) Confidence 0.10 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.67 Pain Relevance 0.13
However, strategies to improve detection of myocardial injury by calculating myoglobin/H-FABP ratio haven’t yielded a clear advantage over the measurement of H-FABP alone.
Positive_regulation (calculating) of H-FABP associated with injury
10) Confidence 0.07 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.64 Pain Relevance 0.12
Both plasma H-FABP and myoglobin levels were found to increase sharply after successful reperfusion, slowly after failed reperfusion.
Neg (failed) Positive_regulation (increase) of H-FABP in plasma
11) Confidence 0.07 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 0.81 Pain Relevance 0.03
Serial measurements of hFABP in the first 24 h after onset of symptoms in AMI patients can: (a) identify patients who are susceptible to reperfusion strategies, (b) detect perioperative AMIs, (c) distinguish patients who reperfuse their infarct-related artery from those who do not, as early as 30 min after starting thrombolytic treatment, (d) detect re-infarction if it occurs within 10 h after symptom onset, and (e) permit an accurate estimation of myocardial infarct size providing important prognosis information.
Positive_regulation (measurements) of hFABP in artery associated with infarction and myocardial infarction
12) Confidence 0.01 Published 2007 Journal Cardiology Section Abstract Doc Link 16960442 Disease Relevance 0.78 Pain Relevance 0.08

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