INT89616

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 5.35
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (FABP3) cytoskeletal protein binding (FABP3) cytosol (FABP3)
Anatomy Link Frequency
myocardium 3
blood 1
lateral 1
skeletal muscle 1
heart 1
FABP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 27 98.12 Very High Very High Very High
Inflammation 10 66.44 Quite High
cva 15 65.00 Quite High
metalloproteinase 1 42.44 Quite Low
ischemia 16 40.80 Quite Low
Inflammatory marker 3 19.60 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 20 100.00 Very High Very High Very High
Myocardial Infarction 156 98.80 Very High Very High Very High
Angina 24 98.12 Very High Very High Very High
Emergencies 16 97.28 Very High Very High Very High
Disease 13 95.80 Very High Very High Very High
Stroke 76 94.36 High High
Acute Coronary Syndrome 10 92.12 High High
Renal Failure 2 91.36 High High
INFLAMMATION 14 66.44 Quite High
Cv Unclassified Under Development 11 65.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we describe a rapid lateral-flow assay for detection of H-FABP.
Gene_expression (detection) of H-FABP in lateral
1) Confidence 0.78 Published 2003 Journal J. Immunol. Methods Section Abstract Doc Link 12969550 Disease Relevance 0.18 Pain Relevance 0
Heart-type fatty acid-binding protein (H-FABP) is a low molecular weight cytoplasmic protein and present abundantly in the myocardium.
Gene_expression (present) of H-FABP in myocardium
2) Confidence 0.76 Published 2000 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 10905760 Disease Relevance 0.28 Pain Relevance 0
Combining H-FABP and cardiac troponin T also improved the sensitivity in the detection of AMI (97% vs 71%, p <0.05) but demonstrated a greater misclassification rate (25% vs 9%, p <0.05).
Gene_expression (Combining) of H-FABP associated with myocardial infarction
3) Confidence 0.68 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20102882 Disease Relevance 0.64 Pain Relevance 0.17
With this rapid and sensitive immunotest, H-FABP could soon be introduced into clinical practice.
Gene_expression (introduced) of H-FABP
4) Confidence 0.67 Published 2003 Journal J. Immunol. Methods Section Abstract Doc Link 12969550 Disease Relevance 0.27 Pain Relevance 0.09
When the myocardium is injured, as in the case of myocardial infarction, low molecular weight cytoplasmic proteins including H-FABP are released into the circulation and H-FABP is detectable in a blood sample.
Gene_expression (detectable) of H-FABP in myocardium associated with myocardial infarction
5) Confidence 0.66 Published 2000 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 10905760 Disease Relevance 0.39 Pain Relevance 0
H-FABP is rapidly released into the circulation following myocardial injury, and is detectable within 2 to 3 hours of the onset of clinical symptoms [48].
Gene_expression (detectable) of H-FABP associated with injury
6) Confidence 0.33 Published 2008 Journal Crit Care Section Body Doc Link PMC2481437 Disease Relevance 1.18 Pain Relevance 0.17
Initial blood samples were drawn for H-FABP, myoglobin, creatine kinase isoenzyme MB (CK-MB), and cardiac troponin-I (cTnI) measurements.
Gene_expression (drawn) of H-FABP in blood
7) Confidence 0.28 Published 2011 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC3012849 Disease Relevance 0.70 Pain Relevance 0.10
One possibility is that the levels of H-FABP in cardiac muscles are 2 to 10 folds higher than the levels in skeletal muscle, while the levels of myoglobin in cardiac muscles are 2 folds lower than the levels in skeletal muscles.
Gene_expression (levels) of H-FABP in cardiac muscles
8) Confidence 0.25 Published 2011 Journal Journal of Korean Medical Science Section Body Doc Link PMC3012849 Disease Relevance 0.56 Pain Relevance 0
For example, heart-fatty acid binding protein (H-FABP) was initially found over-expressed in postmortem compared to antemortem CSF and was validated as a potential biomarker of Creutzfeld–Jakob disease (Guillaume et al. 2003) and stroke (Zimmermann-Ivol et al. 2004).
Gene_expression (expressed) of H-FABP in heart associated with stroke and disease
9) Confidence 0.21 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717829 Disease Relevance 0.64 Pain Relevance 0
After myocardial ischemic damage, hFABP can be detected in the blood as early as 1-3 h after onset of chest pain, with peak values reached at 6-8 h and plasma levels returning to normal within 24-30 h. hFABP's clinical diagnostic value is very limited in the presence of renal failure and skeletal muscle diseases as it is completely renally eliminated.
Gene_expression (detected) of hFABP in skeletal muscle associated with angina, renal failure and disease
10) Confidence 0.01 Published 2007 Journal Cardiology Section Abstract Doc Link 16960442 Disease Relevance 0.50 Pain Relevance 0.10

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