INT8962

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Context Info
Confidence 0.71
First Reported 1980
Last Reported 2010
Negated 2
Speculated 8
Reported most in Abstract
Documents 110
Total Number 119
Disease Relevance 39.67
Pain Relevance 71.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
striatum 8
neurons 8
brain 7
fat 7
spinal cord 4
Cpe (Mus musculus)
Cpe - R6L (1)
Pain Link Frequency Relevance Heat
Enkephalin 615 100.00 Very High Very High Very High
Morphine 114 100.00 Very High Very High Very High
Opioid 63 100.00 Very High Very High Very High
substance P 61 100.00 Very High Very High Very High
Dynorphin 48 100.00 Very High Very High Very High
agonist 48 100.00 Very High Very High Very High
Neurotransmitter 26 100.00 Very High Very High Very High
Somatostatin 11 100.00 Very High Very High Very High
antinociception 35 99.98 Very High Very High Very High
Analgesic 22 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 640 99.84 Very High Very High Very High
Sprains And Strains 67 99.74 Very High Very High Very High
Parkinson's Disease 23 99.68 Very High Very High Very High
Disease 93 99.60 Very High Very High Very High
Cancer 782 99.52 Very High Very High Very High
Aids-related Complex 396 99.50 Very High Very High Very High
Breast Cancer 60 99.36 Very High Very High Very High
Neuroblastoma 25 99.24 Very High Very High Very High
Anxiety Disorder 77 99.18 Very High Very High Very High
Convulsion 22 99.18 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Physiological concentrations of met-enkephalin produced the same effect in vitro but not leu-enkephalin.
Gene_expression (produced) of leu-enkephalin associated with enkephalin
1) Confidence 0.71 Published 1988 Journal J. Neuroimmunol. Section Abstract Doc Link 3170721 Disease Relevance 0.42 Pain Relevance 0.55
Leu-enkephalin is metabolized in vivo faster than previously reported in vitro in mouse plasma.
Gene_expression (metabolized) of Leu-enkephalin in plasma associated with enkephalin
2) Confidence 0.67 Published 1992 Journal Peptides Section Abstract Doc Link 1523167 Disease Relevance 0 Pain Relevance 0.35
The CBA strain had significantly higher Met-enkephalin levels in all 3 regions than the BALB/c strain.
Gene_expression (levels) of Met-enkephalin associated with enkephalin and sprains and strains
3) Confidence 0.67 Published 1987 Journal Brain Res. Section Abstract Doc Link 3607458 Disease Relevance 0.37 Pain Relevance 0.56
Physiological concentrations of met-enkephalin produced the same effect in vitro but not leu-enkephalin.
Gene_expression (produced) of met-enkephalin associated with enkephalin
4) Confidence 0.62 Published 1988 Journal J. Neuroimmunol. Section Abstract Doc Link 3170721 Disease Relevance 0.42 Pain Relevance 0.49
Physiological concentrations of met-enkephalin produced the same effect in vitro but not leu-enkephalin.
Gene_expression (produced) of leu-enkephalin associated with enkephalin
5) Confidence 0.62 Published 1988 Journal J. Neuroimmunol. Section Abstract Doc Link 3170721 Disease Relevance 0.42 Pain Relevance 0.55
mu, delta and kappa opioid receptor agonists, morphiceptin, Leu-enkephalin and dynorphin reduced monosynaptic EPSPs evoked in spinal cord neurons by stimulation of spinal cord neurons in a mouse cell culture system.
Gene_expression (reduced) of Leu-enkephalin in spinal cord neurons associated with dynorphin, agonist, kappa opioid receptor, enkephalin and spinal cord
6) Confidence 0.61 Published 1987 Journal Peptides Section Abstract Doc Link 2889202 Disease Relevance 0 Pain Relevance 0.93
At 6 to 8 weeks, an age prior to the onset of obesity, levels of dynorphin peptides are decreased in all brain regions, whereas levels of ir-Met-enkephalin are differentially altered.
Gene_expression (levels) of ir-Met-enkephalin in brain associated with dynorphin, obesity and enkephalin
7) Confidence 0.60 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12438557 Disease Relevance 0.26 Pain Relevance 0.58
Levels of Leu-enkephalin in Cpefat/Cpefat mouse brain are approximately 5-fold lower than those in control brain.
Gene_expression (Levels) of Leu-enkephalin in brain associated with enkephalin
8) Confidence 0.60 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8940036 Disease Relevance 0 Pain Relevance 0.34
During electrical blockade, none of the concentrations of NMDA tested showed any effect on enkephalin expression, neither could NMDA pre-treatment prevent the TTX-induced down-regulation of mRNAppENK.
Gene_expression (expression) of enkephalin associated with tetrodotoxin and enkephalin
9) Confidence 0.59 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8353931 Disease Relevance 0 Pain Relevance 0.74
Through a systematic reduction of peptide structure, a series of 25 tripeptide and 5 dipeptide amide and alcohol analogs of enkephalin were synthesized and assayed in vitro on the stimulated guinea pig ileum.
Gene_expression (synthesized) of enkephalin in ileum associated with enkephalin and alcohol
10) Confidence 0.59 Published 1981 Journal Peptides Section Abstract Doc Link 6272246 Disease Relevance 0 Pain Relevance 0.69
These findings suggested that mesolimbic enkephalin is augmented following ethanol consumption, and that endogenous low enkephalin biosynthesis may be associated with an increased vulnerability for ethanol abuse.
Gene_expression (biosynthesis) of enkephalin associated with alcohol addiction and enkephalin
11) Confidence 0.57 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8884235 Disease Relevance 0.24 Pain Relevance 0.92
Genotypic differences in mesolimbic enkephalin gene expression in DBA/2J and C57BL/6J inbred mice.
Gene_expression (expression) of enkephalin associated with enkephalin
12) Confidence 0.57 Published 1996 Journal Eur. J. Pharmacol. Section Title Doc Link 8884235 Disease Relevance 0.23 Pain Relevance 0.70
Neurochemical analysis of C57 mice, following high voluntary ethanol consumption (approximately 17 g/kg/day), revealed markedly higher enkephalin gene expression in the striatum and mid brain compared to ethanol-naive animals.
Gene_expression (expression) of enkephalin in brain associated with enkephalin
13) Confidence 0.57 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8884235 Disease Relevance 0.24 Pain Relevance 0.65
No strain differences in enkephalin gene expression was observed in the striatum, hypothalamus, or medulla pons.
Gene_expression (expression) of enkephalin in hypothalamus associated with medulla, enkephalin and sprains and strains
14) Confidence 0.57 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8884235 Disease Relevance 0.24 Pain Relevance 0.57
A peptide analogue of Leu-enkephalin was synthesized in which the amide linkages between Tyr-Gly and Gly-Gly were replaced by ketomethylene groups.
Gene_expression (synthesized) of Leu-enkephalin associated with enkephalin
15) Confidence 0.57 Published 1984 Journal J. Med. Chem. Section Abstract Doc Link 6319699 Disease Relevance 0 Pain Relevance 0.76
The enhancement of spinorphin on the antinociception produced by leu-enkephalin was reversed by pretreatment with naloxone.
Gene_expression (produced) of leu-enkephalin associated with antinociception, narcan and enkephalin
16) Confidence 0.54 Published 2001 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 11829145 Disease Relevance 0.45 Pain Relevance 1.85
Withdrawal from alcohol in withdrawal seizure-prone and -resistant mice: evidence for enkephalin resistance.
Gene_expression (resistance) of enkephalin associated with convulsion, enkephalin, withdrawal and alcohol
17) Confidence 0.53 Published 2001 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 11325389 Disease Relevance 0.56 Pain Relevance 1.88
At neural pH, the enzyme activity within the skin was such that no flux of leucine-enkephalin (YGGFL) was observed and the donor cell concentration of YGGFL decreased rapidly.
Neg (no) Gene_expression (flux) of leucine-enkephalin in skin associated with enkephalin
18) Confidence 0.53 Published 1990 Journal Pharm. Res. Section Abstract Doc Link 2293206 Disease Relevance 0 Pain Relevance 0.40
The concentrations of Met-enkephalin were significantly greater in WSP mice than in WSR mice, whereas synthesis of Met-enkephalin, as reflected by PPE mRNA levels, and transport out of the brain by PTS-1 was not different.
Gene_expression (synthesis) of Met-enkephalin in brain associated with enkephalin
19) Confidence 0.48 Published 1998 Journal Alcohol Section Abstract Doc Link 9426834 Disease Relevance 0.47 Pain Relevance 0.92
Two analogues of Leu-enkephalin, in which the terminal tyrosine-1 residue has been replaced by a conformationally restrained tyrosine analogue, have been synthesized by classical solution methods, and their opiate agonist potencies on electrically stimulated guinea pig ileum and mouse vas deferens preparations were determined in comparison with Leu-enkephalin.
Gene_expression (synthesized) of Leu-enkephalin in ileum associated with agonist, opiate and enkephalin
20) Confidence 0.48 Published 1983 Journal J. Med. Chem. Section Abstract Doc Link 6842517 Disease Relevance 0.06 Pain Relevance 0.67

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