INT8963

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.68
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 7.50
Pain Relevance 10.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
plasma 2
spinal cord 2
brainstem 2
Neuronal 2
midbrain 1
Trh (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 57 100.00 Very High Very High Very High
substance P 29 100.00 Very High Very High Very High
Serotonin 5 100.00 Very High Very High Very High
Intracerebroventricular 1 99.60 Very High Very High Very High
antinociception 18 99.52 Very High Very High Very High
Spinal cord 61 99.20 Very High Very High Very High
withdrawal 4 98.88 Very High Very High Very High
medulla 68 98.56 Very High Very High Very High
Clonidine 16 98.16 Very High Very High Very High
Morphine 10 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 66 99.52 Very High Very High Very High
Galactorrhea 12 99.16 Very High Very High Very High
Hypothermia 14 98.44 Very High Very High Very High
Cancer 141 97.96 Very High Very High Very High
Sleep Disorders 2 97.52 Very High Very High Very High
Metastasis 45 97.24 Very High Very High Very High
Hyperglycemia 11 95.96 Very High Very High Very High
Targeted Disruption 9 92.48 High High
Stress 4 90.00 High High
Body Weight 4 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuronal mechanisms involved in the jumping produced by thyrotropin releasing hormone (TRH) plus apomorphine were studied in mice.
Gene_expression (produced) of thyrotropin releasing hormone in Neuronal
1) Confidence 0.68 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6281836 Disease Relevance 0 Pain Relevance 0.07
Neuronal mechanisms involved in the jumping produced by thyrotropin releasing hormone (TRH) plus apomorphine were studied in mice.
Gene_expression (produced) of TRH in Neuronal
2) Confidence 0.68 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6281836 Disease Relevance 0 Pain Relevance 0.07
Both metabolites of TRH were less effective than TRH.
Gene_expression (effective) of TRH
3) Confidence 0.68 Published 1987 Journal Pain Section Abstract Doc Link 3118323 Disease Relevance 0 Pain Relevance 0.22
Both metabolites of TRH were less effective than TRH.
Gene_expression (effective) of TRH
4) Confidence 0.68 Published 1987 Journal Pain Section Abstract Doc Link 3118323 Disease Relevance 0 Pain Relevance 0.22
The antinociception induced by TRH does not appear to depend on the biotransformation of TRH to its metabolites since they are less active than TRH itself.
Gene_expression (biotransformation) of TRH associated with antinociception
5) Confidence 0.68 Published 1987 Journal Pain Section Abstract Doc Link 3118323 Disease Relevance 0 Pain Relevance 0.22
However, both TRH analogs produced long-lasting antagonism of withdrawal hypothermia in mice from which morphine pellets had been removed.
Gene_expression (produced) of TRH associated with hypothermia, withdrawal and morphine
6) Confidence 0.68 Published 1985 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 2996045 Disease Relevance 0.44 Pain Relevance 1.02
C.NMTA-induced antinociception was significantly potentiated by simultaneously intracerebroventricular or intraperitoneal injection of TRH (approximately 20-50%) in a dose-dependent manner, whereas the effect of morphine was not influenced significantly by TRH.
Gene_expression (injection) of TRH associated with antinociception, intracerebroventricular and morphine
7) Confidence 0.68 Published 1984 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 6143808 Disease Relevance 0 Pain Relevance 0.58
Central injection of thyrotropin-releasing hormone (TRH) potently blocked the development of, as well as rapidly reversed, 2-deoxyglucose (2-DG)-stimulated hyperglycemia in mice.
Gene_expression (injection) of TRH associated with hyperglycemia
8) Confidence 0.68 Published 1988 Journal Peptides Section Abstract Doc Link 2896345 Disease Relevance 0.22 Pain Relevance 0.12
Central injection of thyrotropin-releasing hormone (TRH) potently blocked the development of, as well as rapidly reversed, 2-deoxyglucose (2-DG)-stimulated hyperglycemia in mice.
Gene_expression (injection) of thyrotropin-releasing hormone associated with hyperglycemia
9) Confidence 0.68 Published 1988 Journal Peptides Section Abstract Doc Link 2896345 Disease Relevance 0.22 Pain Relevance 0.12
Both of these effects of IC NT were completely antagonized by concomitant administration of equimolar doses of thyrotropin-releasing hormone (TRH) and several TRH congeners including 3-methyl-His-TRH (pGlu-3-methyl-His-Pro-NH2), MK-771 (pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide), beta-ala-TRH (pGlu-His-Pro-beta-ala-NH2), and RX-77368 (pGlu-His-dimethyl-Pro-NH2).
Gene_expression (doses) of thyrotropin-releasing hormone
10) Confidence 0.67 Published 1984 Journal Regul. Pept. Section Abstract Doc Link 6425994 Disease Relevance 0.31 Pain Relevance 0.31
Both of these effects of IC NT were completely antagonized by concomitant administration of equimolar doses of thyrotropin-releasing hormone (TRH) and several TRH congeners including 3-methyl-His-TRH (pGlu-3-methyl-His-Pro-NH2), MK-771 (pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide), beta-ala-TRH (pGlu-His-Pro-beta-ala-NH2), and RX-77368 (pGlu-His-dimethyl-Pro-NH2).
Gene_expression (doses) of TRH
11) Confidence 0.67 Published 1984 Journal Regul. Pept. Section Abstract Doc Link 6425994 Disease Relevance 0.31 Pain Relevance 0.31
Both of these effects of IC NT were completely antagonized by concomitant administration of equimolar doses of thyrotropin-releasing hormone (TRH) and several TRH congeners including 3-methyl-His-TRH (pGlu-3-methyl-His-Pro-NH2), MK-771 (pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide), beta-ala-TRH (pGlu-His-Pro-beta-ala-NH2), and RX-77368 (pGlu-His-dimethyl-Pro-NH2).
Gene_expression (doses) of TRH
12) Confidence 0.67 Published 1984 Journal Regul. Pept. Section Abstract Doc Link 6425994 Disease Relevance 0.34 Pain Relevance 0.34
Both of these effects of IC NT were completely antagonized by concomitant administration of equimolar doses of thyrotropin-releasing hormone (TRH) and several TRH congeners including 3-methyl-His-TRH (pGlu-3-methyl-His-Pro-NH2), MK-771 (pyro-2-aminoadipyl-histidyl-thiazolidine-4-carboxamide), beta-ala-TRH (pGlu-His-Pro-beta-ala-NH2), and RX-77368 (pGlu-His-dimethyl-Pro-NH2).
Gene_expression (doses) of TRH
13) Confidence 0.67 Published 1984 Journal Regul. Pept. Section Abstract Doc Link 6425994 Disease Relevance 0.31 Pain Relevance 0.31
Besides showing the loss of motoneurons when the symptoms are expressed around the age of 3 weeks, we have also demonstrated the presumed 'sprouting' of neuronal processes in the cervical spinal ventral horn which contain immunoreactive (IR) serotonin (5-HT), substance P (SP) and methionine and leucine enkephalins (ME, LE), as well as thyrotropin-releasing hormone (TRH).
Gene_expression (expressed) of TRH in horn associated with enkephalin, serotonin and substance p
14) Confidence 0.67 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10076901 Disease Relevance 0.26 Pain Relevance 0.52
Central injection of thyrotropin-releasing hormone (TRH) prevented the rise in plasma glucose due to clonidine challenge in mice.
Gene_expression (injection) of TRH in plasma associated with clonidine
15) Confidence 0.64 Published 1988 Journal Peptides Section Abstract Doc Link 3138675 Disease Relevance 0.14 Pain Relevance 0.38
Single-cell reverse-transcription-PCR demonstrated variable expression of the two known TRH receptors in the majority of TMN neurons.
Gene_expression (expression) of TRH in neurons
16) Confidence 0.60 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19357273 Disease Relevance 0.19 Pain Relevance 0.27
The results indicate that lithium plus haloperidol or TRH produces jumping in which dopaminergic and cholinergic inhibition as well as noradrenergic activation may be involved.
Gene_expression (produces) of TRH
17) Confidence 0.58 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6805023 Disease Relevance 0 Pain Relevance 0.18
Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla).
Gene_expression (levels) of thyrotropin releasing hormone in brainstem associated with medulla, disease, spinal cord and substance p
18) Confidence 0.49 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697212 Disease Relevance 0.27 Pain Relevance 0.55
Alteration in the levels of thyrotropin releasing hormone, substance P and enkephalins in the spinal cord, brainstem, hypothalamus and midbrain of the Wobbler mouse at different stages of the motoneuron disease.
Gene_expression (levels) of thyrotropin releasing hormone in spinal cord associated with medulla, midbrain, enkephalin, disease, spinal cord and substance p
19) Confidence 0.48 Published 1992 Journal Neuroscience Section Title Doc Link 1383870 Disease Relevance 0.45 Pain Relevance 1.10
In the POMC ko mouse, there is reduced pituitary TSH and hypothalamic TRH production, but the thyroid gland compensates, with elevated plasma T3 and T4 [149].
Gene_expression (production) of TRH in plasma
20) Confidence 0.21 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.22 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox