INT8965

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Context Info
Confidence 0.57
First Reported 1983
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 5.28
Pain Relevance 4.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
brain 3
motoneuron 2
spinal 1
spinal cord 1
brainstem 1
Trh (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
Spinal cord 25 99.20 Very High Very High Very High
midbrain 3 98.84 Very High Very High Very High
medulla 18 98.56 Very High Very High Very High
Morphine 3 97.64 Very High Very High Very High
Somatostatin 41 88.64 High High
Neuropeptide 10 80.24 Quite High
Cholecystokinin 1 79.04 Quite High
Disease Link Frequency Relevance Heat
Disease 38 99.72 Very High Very High Very High
Syndrome 27 99.54 Very High Very High Very High
Galactorrhea 12 99.24 Very High Very High Very High
Targeted Disruption 6 97.76 Very High Very High Very High
Parkinson's Disease 6 97.56 Very High Very High Very High
Carcinoid 60 97.16 Very High Very High Very High
Acromegaly 54 92.76 High High
Cancer 141 90.88 High High
Psychosis 1 87.56 High High
Dyskinesias 1 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla).
Positive_regulation (increased) of thyrotropin releasing hormone in brainstem associated with medulla, disease, spinal cord and substance p
1) Confidence 0.57 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697212 Disease Relevance 0.27 Pain Relevance 0.55
It is suggested that gastrointestinal transit effects of TRH are not mediated via its conversion to cyclo (His-Pro).
Neg (not) Positive_regulation (mediated) of TRH
2) Confidence 0.50 Published 1985 Journal Peptides Section Abstract Doc Link 3929234 Disease Relevance 0 Pain Relevance 0.27
Increase in fiber density for immunoreactive serotonin, substance P, enkephalin and thyrotropin-releasing hormone occurs during the early presymptomatic period of motoneuron disease in Wobbler mouse spinal cord ventral horn.
Positive_regulation (Increase) of thyrotropin-releasing hormone in motoneuron associated with enkephalin, disease, serotonin, spinal cord and substance p
3) Confidence 0.50 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10076901 Disease Relevance 0.26 Pain Relevance 0.64
Gln-Leu-Pro-Gly, a progenitor sequence for the thyrotropin-releasing hormone (TRH) analogue [Leu(2)]TRH (pGlu-Leu-Pro-NH(2)), was covalently and bioreversibly modified on its N- and C-termini (by a 1,4-dihydrotrigonellyl and a cholesteryl group, respectively) to create lipoidal brain-targeting systems for the TRH analogue.
Positive_regulation (modified) of TRH in brain
4) Confidence 0.47 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10579819 Disease Relevance 0 Pain Relevance 0.03
Gln-Leu-Pro-Gly, a progenitor sequence for the thyrotropin-releasing hormone (TRH) analogue [Leu(2)]TRH (pGlu-Leu-Pro-NH(2)), was covalently and bioreversibly modified on its N- and C-termini (by a 1,4-dihydrotrigonellyl and a cholesteryl group, respectively) to create lipoidal brain-targeting systems for the TRH analogue.
Positive_regulation (modified) of thyrotropin-releasing hormone in brain
5) Confidence 0.47 Published 1999 Journal J. Med. Chem. Section Abstract Doc Link 10579819 Disease Relevance 0 Pain Relevance 0.03
By radioimmunoassay, increased concentrations of spinal SP, TRH, and 5-HT, as well as leucine and methionine enkephalins (LE, ME) have been documented.
Positive_regulation (increased) of TRH in spinal associated with enkephalin and substance p
6) Confidence 0.46 Published 1992 Journal Brain Res. Section Abstract Doc Link 1525646 Disease Relevance 0.23 Pain Relevance 0.69
The data indicate a similarity in the mode of TRH and MSH activation of the MCI receptor.
Positive_regulation (activation) of TRH
7) Confidence 0.42 Published 1999 Journal Peptides Section Abstract Doc Link 10447100 Disease Relevance 0.14 Pain Relevance 0.07
Highly significant increases of the peptides (except thyrotropin releasing hormone) appear in hypothalamus and midbrain only late in the motoneuron disease.
Positive_regulation (increases) of thyrotropin releasing hormone in motoneuron associated with midbrain and disease
8) Confidence 0.40 Published 1992 Journal Neuroscience Section Abstract Doc Link 1383870 Disease Relevance 0.60 Pain Relevance 1.37
Wobbler mice selected at various ages and stages during the disease process show increased levels of thyrotropin releasing hormone and substance P in spinal cord and brainstem (medulla).
Positive_regulation (increased) of thyrotropin releasing hormone in spinal cord associated with medulla, disease, spinal cord and substance p
9) Confidence 0.19 Published 1990 Journal Brain Res. Section Abstract Doc Link 1697212 Disease Relevance 0.27 Pain Relevance 0.55
In agreement with post-mortem brain studies, increased responses of prolactin secretion to TRH in vivo also suggested a decreased D-2 receptor function in parkinsonian patients with recent onset and supersensitivity in patients with on-off phenomena.
Positive_regulation (increased) of TRH in brain associated with parkinson's disease
10) Confidence 0.17 Published 1983 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 6308149 Disease Relevance 0.58 Pain Relevance 0.25
Specific dynamical tests for GH excess do not allow classification with certainty in either category, although most patients with ectopic GHRH syndrome exhibit a paradoxical increase of GH after TRH and glucose (i.e. >50%) and a blunted GH rise (<100%) after exogenous GHRH injection [33].
Positive_regulation (increase) of TRH associated with syndrome
11) Confidence 0.17 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.14 Pain Relevance 0
The patients reported here all exhibited GH increase after TRH, and two had mild hyperprolactinemia.
Positive_regulation (increase) of TRH associated with galactorrhea
12) Confidence 0.11 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 1.37 Pain Relevance 0
Note the GH increase after TRH (200 ?
Positive_regulation (increase) of TRH
13) Confidence 0.10 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.41 Pain Relevance 0

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