INT89657

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2006
Negated 1
Speculated 0
Reported most in Abstract
Documents 24
Total Number 26
Disease Relevance 15.15
Pain Relevance 18.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnj9) plasma membrane (Kcnj9)
Anatomy Link Frequency
brain 7
spinal cord 4
neurons 4
dopamine neurons 3
paw 3
Kcnj9 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 39 99.98 Very High Very High Very High
analgesia 46 99.80 Very High Very High Very High
Dopamine 201 99.50 Very High Very High Very High
Morphine 90 99.40 Very High Very High Very High
Locus ceruleus 36 99.24 Very High Very High Very High
agonist 26 99.20 Very High Very High Very High
Opioid 33 99.12 Very High Very High Very High
substantia gelatinosa 1 98.92 Very High Very High Very High
Spinal cord 17 98.60 Very High Very High Very High
Dorsal horn 3 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 234 100.00 Very High Very High Very High
Nociception 6 98.88 Very High Very High Very High
Death 3 93.84 High High
Hyperalgesia 40 92.40 High High
Depression 4 76.64 Quite High
Pain 3 43.04 Quite Low
Coma 6 5.00 Very Low Very Low Very Low
Recurrence 6 5.00 Very Low Very Low Very Low
Inhalant Abuse 3 5.00 Very Low Very Low Very Low
Alcohol Addiction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Paw-lick latencies for Kir3.4 knockout mice were similar to those of wild-type mice, consistent with the restricted expression pattern of Kir3.4 subunit in the mouse brain.
Gene_expression (expression) of Kir3 in Paw associated with targeted disruption
1) Confidence 0.77 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 1.38 Pain Relevance 0.89
Western blotting was used to probe for the presence of Kir3.1, Kir3.2, Kir3.3, and Kir3.4 subunits in the mouse brain and spinal cord.
Gene_expression (presence) of Kir3 in spinal cord associated with spinal cord
2) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 0.78 Pain Relevance 0.64
Western blotting was used to probe for the presence of Kir3.1, Kir3.2, Kir3.3, and Kir3.4 subunits in the mouse brain and spinal cord.
Gene_expression (presence) of Kir3 in spinal cord associated with spinal cord
3) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 0.79 Pain Relevance 0.65
Western blotting was used to probe for the presence of Kir3.1, Kir3.2, Kir3.3, and Kir3.4 subunits in the mouse brain and spinal cord.
Gene_expression (presence) of Kir3 in spinal cord associated with spinal cord
4) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 0.78 Pain Relevance 0.64
Hot-plate paw-lick latencies for wild-type, Kir3.2 knockout, Kir3.3 knockout, and Kir3.4 knockout mice were measured at 52 degrees C and 55 degrees C, following the s.c. injection of either saline or 10 mg/kg morphine.
Gene_expression (knockout) of Kir3 in paw associated with targeted disruption and morphine
5) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 0.93 Pain Relevance 0.72
Western blotting was used to probe for the presence of Kir3.1, Kir3.2, Kir3.3, and Kir3.4 subunits in the mouse brain and spinal cord.
Gene_expression (presence) of Kir3 in spinal cord associated with spinal cord
6) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 0.77 Pain Relevance 0.64
Furthermore, the activation of Kir3 channels containing the Kir3.2 subunit contributes to the analgesia evoked by a moderate dose of morphine.
Gene_expression (containing) of Kir3 associated with morphine and analgesia
7) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 1.30 Pain Relevance 1.17
Furthermore, the activation of Kir3 channels containing the Kir3.2 subunit contributes to the analgesia evoked by a moderate dose of morphine.
Gene_expression (containing) of Kir3 associated with morphine and analgesia
8) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 1.29 Pain Relevance 1.16
Hot-plate paw-lick latencies for wild-type, Kir3.2 knockout, Kir3.3 knockout, and Kir3.4 knockout mice were measured at 52 degrees C and 55 degrees C, following the s.c. injection of either saline or 10 mg/kg morphine.
Gene_expression (knockout) of Kir3 in paw associated with targeted disruption and morphine
9) Confidence 0.66 Published 2002 Journal Neuroreport Section Abstract Doc Link 12499858 Disease Relevance 0.92 Pain Relevance 0.72
All four GIRK subunits are expressed in the brain, and there is a general consensus concerning the expression patterns of GIRK1, GIRK2, and GIRK3.
Gene_expression (expression) of GIRK3 in brain
10) Confidence 0.66 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908597 Disease Relevance 0 Pain Relevance 0.11
G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons.
Gene_expression (containing) of Kir3 in neurons associated with locus ceruleus, potassium channel and opioid
11) Confidence 0.59 Published 2002 Journal J. Neurosci. Section Title Doc Link 12040038 Disease Relevance 0.40 Pain Relevance 0.88
G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons.
Gene_expression (containing) of Kir3 in neurons associated with locus ceruleus, potassium channel and opioid
12) Confidence 0.59 Published 2002 Journal J. Neurosci. Section Title Doc Link 12040038 Disease Relevance 0.41 Pain Relevance 0.88
We detected GIRK1 (G-protein-gated inwardly rectifying K+ channel subunit 1) and GIRK2 subunits, but not GIRK3, in the superficial layers of the dorsal horn.
Neg (not) Gene_expression (detected) of GIRK3 in dorsal horn associated with dorsal horn
13) Confidence 0.54 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 15028774 Disease Relevance 0.78 Pain Relevance 0.94
Here, the contribution of K(G) channels to the inhibitory effects of opioids on LC neurons was examined using mice that lack the K(G) channel subunits Kir3.2 and Kir3.3.
Gene_expression (lack) of Kir3 in neurons associated with locus ceruleus and opioid
14) Confidence 0.52 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040038 Disease Relevance 0.48 Pain Relevance 0.80
Here, the contribution of K(G) channels to the inhibitory effects of opioids on LC neurons was examined using mice that lack the K(G) channel subunits Kir3.2 and Kir3.3.
Gene_expression (lack) of Kir3 in neurons associated with locus ceruleus and opioid
15) Confidence 0.52 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12040038 Disease Relevance 0.48 Pain Relevance 0.86
All four GIRK subunits are expressed in the brain, and there is a general consensus concerning the expression patterns of GIRK1, GIRK2, and GIRK3.
Gene_expression (patterns) of GIRK3 in brain
16) Confidence 0.51 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908597 Disease Relevance 0 Pain Relevance 0.11
All four GIRK subunits are expressed in the brain, and there is a general consensus concerning the expression patterns of GIRK1, GIRK2, and GIRK3.
Gene_expression (expressed) of GIRK in brain
17) Confidence 0.51 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908597 Disease Relevance 0 Pain Relevance 0.10
We found that the GIRK channel subunits GIRK1 and GIRK2 were concentrated in the outer layer of the substantia gelatinosa of the dorsal horn.
Gene_expression (concentrated) of GIRK in substantia gelatinosa associated with substantia gelatinosa and dorsal horn
18) Confidence 0.36 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15814785 Disease Relevance 0 Pain Relevance 1.19
This happens because the coupling efficiency of Kir3/GIRK channels in dopamine neurons is very low (the EC50 differs by an order of magnitude between GABA and dopamine neurons), which in turn is due to the cell type–specific subunit expression of Kir3/GIRK channels [17].
Gene_expression (expression) of GIRK in dopamine neurons associated with gaba and dopamine
19) Confidence 0.32 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0.08 Pain Relevance 0.83
This happens because the coupling efficiency of Kir3/GIRK channels in dopamine neurons is very low (the EC50 differs by an order of magnitude between GABA and dopamine neurons), which in turn is due to the cell type–specific subunit expression of Kir3/GIRK channels [17].
Gene_expression (expression) of Kir3 in dopamine neurons associated with gaba and dopamine
20) Confidence 0.32 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1635740 Disease Relevance 0.08 Pain Relevance 0.83

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