INT89661

Context Info Confidence 0.21 First Reported 1995 Last Reported 2010 Negated 3 Speculated 1 Reported most in Body Documents 102 Total Number 104 Disease Relevance 69.91 Pain Relevance 39.57

Anatomy Link Frequency macrophages 12 microglia 3 plasma 2 brain 2 monocyte 2 Hrec (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 2451 100.00 Inflammation 1340 100.00 chemokine 208 100.00 Inflammatory mediators 48 100.00 rheumatoid arthritis 727 99.90 fibrosis 51 99.64 metalloproteinase 25 99.56 Osteoarthritis 30 99.44 Spinal cord 462 99.40 Sciatic nerve 7 99.36

Disease Link Frequency Relevance Heat INFLAMMATION 1333 100.00 Cancer 232 100.00 Necrosis 113 100.00 Pancreatitis 139 99.96 Adhesions 21 99.92 Rheumatoid Arthritis 727 99.90 Wallerian Degeneration 4 99.90 Fibrosis 47 99.64 Disease 965 99.56 Osteoarthritis 30 99.44

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Event

Anatomy

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Speculation

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Disease term

The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits.

Gene_expression (expression) of cytokines in brain associated with inflammatory response, disease, amyloid plaque and cytokine

1) Confidence 0.21 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908610 Disease Relevance 1.12 Pain Relevance 0.50

To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).

Gene_expression (expression) of cytokines in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine

2) Confidence 0.06 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.07 Pain Relevance 0.71

To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).

Gene_expression (expression) of cytokines in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine

3) Confidence 0.06 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.15 Pain Relevance 0.76

Impaired regulatory and efferent lymphocyte capacities, increased synthesis of cytokines, immunoglobulins, heterologous (anti-viral, anti-bacterial or antigliadin), autologous (to parietal cells, microsome mitochondria, tissue transglutaminase) antibodies, formation of immune complexes, autoimmune reactions and secondary immunodeficiency are specific immune mechanisms of the pathological process development, its synchronization and progression in patients with alimentary system diseases.

Gene_expression (synthesis) of cytokines in alimentary system associated with disease, immunodeficiency and cytokine

4) Confidence 0.06 Published 2007 Journal Eksp Klin Gastroenterol Section Abstract Doc Link 17539352 Disease Relevance 0.48 Pain Relevance 0.05

We evaluated the expression pattern of some cytokines and their receptors in C57Bl/6J bleomycin-sensitive and Balb/C bleomycin-resistant mice.

Gene_expression (expression) of cytokines associated with cytokine

5) Confidence 0.05 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.33 Pain Relevance 0.43

Recent evidence indicates that the upregulated expression of cytokines and cytokine receptors may be involved.

Gene_expression (expression) of cytokines associated with cytokine

6) Confidence 0.05 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.33 Pain Relevance 0.42

On the contrary, the production of the Th2 cytokines IL-4 and IL-10 was lessened to the same degree by morphine in WT and RelB-/- mice.

Gene_expression (production) of cytokines associated with morphine and cytokine

7) Confidence 0.05 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.17 Pain Relevance 1.15

It is possible that macrophages, NK, and CD8 cells are responsible for the increased levels of TH1 cytokines observed in this study, which would agree with other murine models [21, 30, 38, 39].

Gene_expression (levels) of cytokines in macrophages associated with cytokine

8) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.85 Pain Relevance 0.05

Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice.

Gene_expression (production) of cytokines in macrophage associated with cytokine and morphine

9) Confidence 0.05 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.19 Pain Relevance 1.02

Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice.

Gene_expression (production) of cytokines in macrophage associated with cytokine and morphine

10) Confidence 0.05 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.17 Pain Relevance 0.91

Resistance to T. cruzi infection has been associated with the production of the pro-inflammatory cytokines IL-12 and IFN-?

Gene_expression (production) of cytokines associated with inflammation, infection and cytokine

11) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.61 Pain Relevance 0.18

Together, our data provide novel insight regarding differential expression of cytokines, particularly TNF-?

Gene_expression (expression) of cytokines associated with cytokine

12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.75 Pain Relevance 0.37

eosinophil influx (Figure 5), BAL cytokines (IL-13) production (Figure 7) in some degree.

Gene_expression (production) of cytokines in eosinophil associated with cytokine

13) Confidence 0.04 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.52 Pain Relevance 0.22

In study, various cytokines production of BALF cells from OVA-induced control

Gene_expression (production) of cytokines associated with cytokine

14) Confidence 0.04 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.23 Pain Relevance 0.05

Thus, the most beneficial effect on decreasing proinflammatory cytokines expression in the brain and spinal cord was noticed in G93A mice administered with 25×106 MNC hUCB cells and this effect was observed mainly through inhibition of IL-1 ?

Gene_expression (expression) of cytokines in spinal cord associated with spinal cord and cytokine

15) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.08 Pain Relevance 0.41

The Th2 cytokines were found in mice receiving 25×106 cells, whereas prevalent Th1 cytokines were indicated in mice with 50×106 cells.

Gene_expression (found) of cytokines associated with cytokine

16) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.07 Pain Relevance 0.42

There were no human cytokines detected in mice treated with 10×106 cell dose.

Neg (no) Gene_expression (detected) of cytokines associated with cytokine

17) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.23

In the periphery (spleen), decreases in proinflammatory cytokines expression (IL-1 ?

Gene_expression (expression) of cytokines in spleen associated with cytokine

18) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.09 Pain Relevance 0.39

In 62.5% of mice with 50×106 cell treatment, all human cytokines were detected except for IL-5, IL-5, and IL-10 (Th2).

Neg (except) Gene_expression (detected) of cytokines associated with cytokine

19) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.25

As shown in Fig. 7, with the DSS treatment, the expression of proinflammatory cytokines IL-1?

Gene_expression (expression) of cytokines associated with cytokine

20) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.40 Pain Relevance 0.63

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