INT89661
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits. | |||||||||||||||
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To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR). | |||||||||||||||
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To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR). | |||||||||||||||
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Impaired regulatory and efferent lymphocyte capacities, increased synthesis of cytokines, immunoglobulins, heterologous (anti-viral, anti-bacterial or antigliadin), autologous (to parietal cells, microsome mitochondria, tissue transglutaminase) antibodies, formation of immune complexes, autoimmune reactions and secondary immunodeficiency are specific immune mechanisms of the pathological process development, its synchronization and progression in patients with alimentary system diseases. | |||||||||||||||
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We evaluated the expression pattern of some cytokines and their receptors in C57Bl/6J bleomycin-sensitive and Balb/C bleomycin-resistant mice. | |||||||||||||||
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Recent evidence indicates that the upregulated expression of cytokines and cytokine receptors may be involved. | |||||||||||||||
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On the contrary, the production of the Th2 cytokines IL-4 and IL-10 was lessened to the same degree by morphine in WT and RelB-/- mice. | |||||||||||||||
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It is possible that macrophages, NK, and CD8 cells are responsible for the increased levels of TH1 cytokines observed in this study, which would agree with other murine models [21, 30, 38, 39]. | |||||||||||||||
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Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice. | |||||||||||||||
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Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice. | |||||||||||||||
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Resistance to T. cruzi infection has been associated with the production of the pro-inflammatory cytokines IL-12 and IFN-? | |||||||||||||||
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Together, our data provide novel insight regarding differential expression of cytokines, particularly TNF-? | |||||||||||||||
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eosinophil influx (Figure 5), BAL cytokines
(IL-13) production (Figure 7) in some degree. | |||||||||||||||
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In
study, various cytokines production of BALF cells from OVA-induced control | |||||||||||||||
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Thus, the most beneficial effect on decreasing proinflammatory cytokines expression in the brain and spinal cord was noticed in G93A mice administered with 25×106 MNC hUCB cells and this effect was observed mainly through inhibition of IL-1 ? | |||||||||||||||
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The Th2 cytokines were found in mice receiving 25×106 cells, whereas prevalent Th1 cytokines were indicated in mice with 50×106 cells. | |||||||||||||||
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There were no human cytokines detected in mice treated with 10×106 cell dose. | |||||||||||||||
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In the periphery (spleen), decreases in proinflammatory cytokines expression (IL-1 ? | |||||||||||||||
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In 62.5% of mice with 50×106 cell treatment, all human cytokines were detected except for IL-5, IL-5, and IL-10 (Th2). | |||||||||||||||
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As shown in Fig. 7, with the DSS treatment, the expression of proinflammatory cytokines IL-1? | |||||||||||||||
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