INT89661

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Context Info
Confidence 0.21
First Reported 1995
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 102
Total Number 104
Disease Relevance 69.91
Pain Relevance 39.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 12
microglia 3
plasma 2
brain 2
monocyte 2
Hrec (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 2451 100.00 Very High Very High Very High
Inflammation 1340 100.00 Very High Very High Very High
chemokine 208 100.00 Very High Very High Very High
Inflammatory mediators 48 100.00 Very High Very High Very High
rheumatoid arthritis 727 99.90 Very High Very High Very High
fibrosis 51 99.64 Very High Very High Very High
metalloproteinase 25 99.56 Very High Very High Very High
Osteoarthritis 30 99.44 Very High Very High Very High
Spinal cord 462 99.40 Very High Very High Very High
Sciatic nerve 7 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1333 100.00 Very High Very High Very High
Cancer 232 100.00 Very High Very High Very High
Necrosis 113 100.00 Very High Very High Very High
Pancreatitis 139 99.96 Very High Very High Very High
Adhesions 21 99.92 Very High Very High Very High
Rheumatoid Arthritis 727 99.90 Very High Very High Very High
Wallerian Degeneration 4 99.90 Very High Very High Very High
Fibrosis 47 99.64 Very High Very High Very High
Disease 965 99.56 Very High Very High Very High
Osteoarthritis 30 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits.
Gene_expression (expression) of cytokines in brain associated with inflammatory response, disease, amyloid plaque and cytokine
1) Confidence 0.21 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10908610 Disease Relevance 1.12 Pain Relevance 0.50
To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).
Gene_expression (expression) of cytokines in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine
2) Confidence 0.06 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.07 Pain Relevance 0.71
To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).
Gene_expression (expression) of cytokines in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine
3) Confidence 0.06 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.15 Pain Relevance 0.76
Impaired regulatory and efferent lymphocyte capacities, increased synthesis of cytokines, immunoglobulins, heterologous (anti-viral, anti-bacterial or antigliadin), autologous (to parietal cells, microsome mitochondria, tissue transglutaminase) antibodies, formation of immune complexes, autoimmune reactions and secondary immunodeficiency are specific immune mechanisms of the pathological process development, its synchronization and progression in patients with alimentary system diseases.
Gene_expression (synthesis) of cytokines in alimentary system associated with disease, immunodeficiency and cytokine
4) Confidence 0.06 Published 2007 Journal Eksp Klin Gastroenterol Section Abstract Doc Link 17539352 Disease Relevance 0.48 Pain Relevance 0.05
We evaluated the expression pattern of some cytokines and their receptors in C57Bl/6J bleomycin-sensitive and Balb/C bleomycin-resistant mice.
Gene_expression (expression) of cytokines associated with cytokine
5) Confidence 0.05 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.33 Pain Relevance 0.43
Recent evidence indicates that the upregulated expression of cytokines and cytokine receptors may be involved.
Gene_expression (expression) of cytokines associated with cytokine
6) Confidence 0.05 Published 2004 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 15321784 Disease Relevance 0.33 Pain Relevance 0.42
On the contrary, the production of the Th2 cytokines IL-4 and IL-10 was lessened to the same degree by morphine in WT and RelB-/- mice.
Gene_expression (production) of cytokines associated with morphine and cytokine
7) Confidence 0.05 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.17 Pain Relevance 1.15
It is possible that macrophages, NK, and CD8 cells are responsible for the increased levels of TH1 cytokines observed in this study, which would agree with other murine models [21, 30, 38, 39].
Gene_expression (levels) of cytokines in macrophages associated with cytokine
8) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.85 Pain Relevance 0.05
Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice.
Gene_expression (production) of cytokines in macrophage associated with cytokine and morphine
9) Confidence 0.05 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.19 Pain Relevance 1.02
Morphine significantly reduced macrophage production of the proinflammatory cytokines IL-1beta, TNF-alpha, and IL-12 in WT animals, and the drug failed to diminish the production of these cytokines in the RelB-/- mice.
Gene_expression (production) of cytokines in macrophage associated with cytokine and morphine
10) Confidence 0.05 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17023558 Disease Relevance 0.17 Pain Relevance 0.91
Resistance to T. cruzi infection has been associated with the production of the pro-inflammatory cytokines IL-12 and IFN-?
Gene_expression (production) of cytokines associated with inflammation, infection and cytokine
11) Confidence 0.05 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.61 Pain Relevance 0.18
Together, our data provide novel insight regarding differential expression of cytokines, particularly TNF-?
Gene_expression (expression) of cytokines associated with cytokine
12) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.75 Pain Relevance 0.37
eosinophil influx (Figure 5), BAL cytokines

(IL-13) production (Figure 7) in some degree.

Gene_expression (production) of cytokines in eosinophil associated with cytokine
13) Confidence 0.04 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.52 Pain Relevance 0.22
In

study, various cytokines production of BALF cells from OVA-induced control

Gene_expression (production) of cytokines associated with cytokine
14) Confidence 0.04 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.23 Pain Relevance 0.05
Thus, the most beneficial effect on decreasing proinflammatory cytokines expression in the brain and spinal cord was noticed in G93A mice administered with 25×106 MNC hUCB cells and this effect was observed mainly through inhibition of IL-1 ?
Gene_expression (expression) of cytokines in spinal cord associated with spinal cord and cytokine
15) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.08 Pain Relevance 0.41
The Th2 cytokines were found in mice receiving 25×106 cells, whereas prevalent Th1 cytokines were indicated in mice with 50×106 cells.
Gene_expression (found) of cytokines associated with cytokine
16) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.07 Pain Relevance 0.42
There were no human cytokines detected in mice treated with 10×106 cell dose.
Neg (no) Gene_expression (detected) of cytokines associated with cytokine
17) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.23
In the periphery (spleen), decreases in proinflammatory cytokines expression (IL-1 ?
Gene_expression (expression) of cytokines in spleen associated with cytokine
18) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.09 Pain Relevance 0.39
In 62.5% of mice with 50×106 cell treatment, all human cytokines were detected except for IL-5, IL-5, and IL-10 (Th2).
Neg (except) Gene_expression (detected) of cytokines associated with cytokine
19) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.25
As shown in Fig. 7, with the DSS treatment, the expression of proinflammatory cytokines IL-1?
Gene_expression (expression) of cytokines associated with cytokine
20) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698136 Disease Relevance 0.40 Pain Relevance 0.63

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