INT89662

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2011
Negated 8
Speculated 12
Reported most in Body
Documents 169
Total Number 182
Disease Relevance 133.36
Pain Relevance 25.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
Anatomy Link Frequency
plaques 20
cleavage 12
brain 10
hippocampal formation 9
hippocampus 8
App (Mus musculus)
App - V717F (3)
Pain Link Frequency Relevance Heat
Abeta 101 100.00 Very High Very High Very High
Pain 42 100.00 Very High Very High Very High
Sciatic nerve 10 99.92 Very High Very High Very High
Inflammatory stimuli 17 99.70 Very High Very High Very High
Inflammation 2233 99.68 Very High Very High Very High
Hippocampus 1131 99.68 Very High Very High Very High
Thalamus 217 99.68 Very High Very High Very High
nMDA receptor 104 99.68 Very High Very High Very High
Neuropathic pain 24 99.60 Very High Very High Very High
cINOD 691 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 6579 100.00 Very High Very High Very High
Targeted Disruption 6292 100.00 Very High Very High Very High
Alzheimer's Dementia 6094 100.00 Very High Very High Very High
Toxicity 313 100.00 Very High Very High Very High
Down Syndrome 201 100.00 Very High Very High Very High
Cicatrix 2 100.00 Very High Very High Very High
Stress 1128 99.98 Very High Very High Very High
Hypoxia 379 99.98 Very High Very High Very High
Neurodegenerative Disease 723 99.92 Very High Very High Very High
Neuroblastoma 105 99.86 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that overexpression of APP or beta amyloid profoundly affects learning and memory and hippocampal volume.
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP associated with alzheimer's dementia
1) Confidence 0.70 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586551 Disease Relevance 0.50 Pain Relevance 0.26
We examined heterozygous transgenic (Tg) mice that overexpress V717F amyloid precursor protein (APP) for delay eyeblink conditioning (EBC) and hippocampal volume with magnetic resonance imaging (MRI).
Spec (examined) Positive_regulation (overexpress) of Gene_expression (overexpress) of APP associated with targeted disruption, alzheimer's dementia and imagery
2) Confidence 0.70 Published 2002 Journal Neurobiol. Dis. Section Abstract Doc Link 12586551 Disease Relevance 0.42 Pain Relevance 0.20
Taken together, our findings suggest that APP overexpression is beneficial for nerve regeneration processes due to better organization of regenerating fibers, increased survival of motoneurons after autotomy and prevention of neuropathic pain.
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP in nerve associated with neuropathic pain
3) Confidence 0.70 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 19958821 Disease Relevance 0.73 Pain Relevance 0.33
The aim of this study was to examine the role of APP overexpression in peripheral nerve regeneration and neuropathic pain-related behavior in mice.
Spec (examine) Positive_regulation (overexpression) of Spec (examine) Gene_expression (overexpression) of APP in peripheral nerve associated with neuropathic pain
4) Confidence 0.70 Published 2010 Journal Brain Res. Bull. Section Abstract Doc Link 19958821 Disease Relevance 0.67 Pain Relevance 0.47
APP overexpression prevents neuropathic pain and motoneuron death after peripheral nerve injury in mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP in motoneuron associated with pain, nervous system injury, neuropathic pain, death and peripheral nerve injury
5) Confidence 0.70 Published 2010 Journal Brain Res. Bull. Section Title Doc Link 19958821 Disease Relevance 0.71 Pain Relevance 0.78
Is its easy recognition in Tg animals the mere consequence of the artificial overexpression of APP?
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP in mere associated with targeted disruption
6) Confidence 0.69 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.66 Pain Relevance 0
In the APP-C99 (Tg 13592) mouse line, the signal sequence and the 99 amino-acids C terminal fragment (C99) of APP is overexpressed under a cytomegalovirus enhancer/?
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of APP associated with targeted disruption and cytomegalovirus infection
7) Confidence 0.69 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.82 Pain Relevance 0.09
Intriguingly, we also found that stress-responsive increases in APP expression levels occurred only in the hippocampus of female 5XFAD mice.
Positive_regulation (increases) of Gene_expression (expression) of APP in hippocampus associated with stress and hippocampus
8) Confidence 0.69 Published 2010 Journal Mol Brain Section Body Doc Link PMC2988063 Disease Relevance 0.80 Pain Relevance 0.11
Transgenic APP expression was activated by crossing the APPswe/ind mice to animals producing tTA under control of the CaMKII?
Positive_regulation (activated) of Gene_expression (expression) of APP associated with targeted disruption
9) Confidence 0.69 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1283364 Disease Relevance 0.31 Pain Relevance 0
Conversely, overexpression of APP and its proteolytic product, A?
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP
10) Confidence 0.69 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.32 Pain Relevance 0
We report that treatment of 11-month-old Tg2576 mice overexpressing human amyloid precursor protein (APP) with the NSAID ibuprofen for 16 weeks resulted in the dramatic and selective reduction of SDS-soluble beta-amyloid (Abeta)42, whereas it had smaller effects on SDS-soluble Abeta40 levels.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of APP associated with alzheimer's dementia, cinod and abeta
11) Confidence 0.69 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12930788 Disease Relevance 1.13 Pain Relevance 0.47
Additionally, mouse models overexpressing human amyloid precursor protein (APP), the protein from which pathogenic A?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of APP associated with alzheimer's dementia
12) Confidence 0.65 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1276812 Disease Relevance 1.06 Pain Relevance 0.16
It has been demonstrated, using a single transgenic mouse model system that overexpresses the human mutated APP gene, that an immunisation against Abeta(1-42) causes a marked reduction in the amyloid burden in the brain.
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of APP in brain associated with targeted disruption, alzheimer's dementia, immunization and abeta
13) Confidence 0.64 Published 2003 Journal CNS Drugs Section Abstract Doc Link 12751917 Disease Relevance 1.66 Pain Relevance 0.31
-site APP cleavage enzyme (BACE) and C99 protein in an unstimulated condition, whereas, expression of BACE, APP and C99 proteins increased in response to LPS (1 ?
Positive_regulation (increased) of Gene_expression (expression) of APP in cleavage
14) Confidence 0.63 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2556656 Disease Relevance 0.72 Pain Relevance 0.18
However, co-expression of APP and the soluble ectodomain of BACE1 in cells increases the generation of A?
Positive_regulation (increases) of Gene_expression (expression) of APP
15) Confidence 0.62 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0 Pain Relevance 0
In vivo, the absence of LRP in the presence of APP overexpression led to a two fold increase in amyloid deposition, findings supporting the notion that the LRP might play an integral role in A?
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP associated with alzheimer's dementia
16) Confidence 0.62 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.26 Pain Relevance 0
at low levels, Swedish APP-overexpressing Tg mice (Tg2576; [56]) produce robust levels of brain A?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of APP in brain associated with targeted disruption
17) Confidence 0.62 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC2211305 Disease Relevance 0.42 Pain Relevance 0
In vivo, the absence of LRP in the presence of APP overexpression led to a two fold increase in amyloid deposition, findings supporting the notion that the LRP might play an integral role in A?
Positive_regulation (overexpression) of Gene_expression (overexpression) of APP associated with alzheimer's dementia
18) Confidence 0.61 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647160 Disease Relevance 0.52 Pain Relevance 0
To test this hypothesis, transgenic mice that overexpress APP in skeletal muscle were treated for 6 months with a variety of nonsteroidal anti-inflammatory drugs (NSAIDs; naproxen, ibuprofen, carprofen or R-flurbiprofen), a subset of which reduce Abeta in brain and cultured cells.
Positive_regulation (overexpress) of Gene_expression (overexpress) of APP in skeletal muscle associated with targeted disruption, inflammation, cinod and abeta
19) Confidence 0.61 Published 2010 Journal Neurobiol. Dis. Section Abstract Doc Link 20493261 Disease Relevance 1.06 Pain Relevance 0.64
The effects of NSAIDs LY-411575 and DAPT were tested in guinea pig embryonic neuronal cultures to determine whether the selective reductions in Abeta(1-42) observed in cell lines overexpressing human mutant APP can be reproduced in a neuronal model of physiological Abeta production and secretion.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of mutant APP in neuronal associated with cinod and abeta
20) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15340006 Disease Relevance 0.20 Pain Relevance 0.92

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