INT89670

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Context Info
Confidence 0.43
First Reported 2000
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) nucleus (Th)
response to stress (Th) cytoplasm (Th)
Anatomy Link Frequency
striatum 2
Th (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 99.30 Very High Very High Very High
Catecholamine 4 95.36 Very High Very High Very High
fluoxetine 1 92.92 High High
Nicotine 4 92.24 High High
narcan 2 87.48 High High
gABA 2 84.56 Quite High
Serotonin 1 83.76 Quite High
antagonist 1 77.96 Quite High
Dopamine 4 69.12 Quite High
MU agonist 1 64.80 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 78.72 Quite High
Pheochromocytoma 2 75.00 Quite High
Disease 1 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although immunoreactivity for tyrosine hydroxylase (TH) was almost completely lost in the ipsilateral striatum in hemiparkinsonian rats, TH immunoreactivity was detected in transplanted cells and sprouting fibers.
Negative_regulation (lost) of TH Binding (immunoreactivity) of in striatum
1) Confidence 0.43 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15351793 Disease Relevance 0.07 Pain Relevance 0.31
These results indicate that the anti-cholinergic actions of kappa-opioid can be explained partially by its inhibition of both TH enzyme activity and TH synthesis, through suppression of the cAMP/protein kinase A pathway.
Negative_regulation (inhibition) of TH enzyme Binding (activity) of associated with opioid
2) Confidence 0.17 Published 2000 Journal FEBS Lett. Section Abstract Doc Link 10908734 Disease Relevance 0.21 Pain Relevance 0.81

General Comments

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