INT89676

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Context Info
Confidence 0.31
First Reported 1999
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 10
Disease Relevance 8.98
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BID) mitochondrion (BID) cytoplasm (BID)
Anatomy Link Frequency
cleavage 3
BID (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 29 81.36 Quite High
chemokine 19 40.80 Quite Low
Chronic pancreatitis 1 37.16 Quite Low
agonist 28 34.64 Quite Low
alcohol 1 34.24 Quite Low
Inflammation 14 13.80 Low Low
metalloproteinase 56 5.00 Very Low Very Low Very Low
antagonist 24 5.00 Very Low Very Low Very Low
Nerve growth factor 8 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 474 100.00 Very High Very High Very High
Pancreatic Cancer 8 98.84 Very High Very High Very High
Cancer 248 96.36 Very High Very High Very High
Lung Cancer 283 95.08 Very High Very High Very High
Death 63 93.20 High High
Malignant Neoplastic Disease 27 81.60 Quite High
Cleidocranial Dysplasia 1 77.92 Quite High
Carcinoma 5 75.00 Quite High
Hyperplasia 3 75.00 Quite High
Necrosis 8 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-rabbit Bcl-2, Bid, Bax, cytochrome c, and ?
Gene_expression (Anti) of Bid
1) Confidence 0.31 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.33 Pain Relevance 0
g/mL) increased the level of Bcl-2 to 1.68 fold of H2O2 treatment alone and diminished the levels of tBid, Apaf-1, and cytosolic CytC to 0.79, 0.82, and 0.71 fold of H2O2 treatment alone, respectively.
Gene_expression (levels) of tBid
2) Confidence 0.31 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.23 Pain Relevance 0
Western blot analysis was used to evaluate the level of Cyto-C, Bcl-2, Bax, Bid, caspase 3, -9, -8 and PARP expression

Results

Gene_expression (expression) of Bid
3) Confidence 0.28 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2987898 Disease Relevance 0.64 Pain Relevance 0
Since translocation of Bcl-2 families fromthe cytosol to the mitochondria is known to play a key role in mitochondrial-mediated apoptosis induced by a variety of apoptotic stimuli, we investigated the altered expression levels of the members of Bcl-2 family proteins such as, Bcl-2, Bax and Bid.
Spec (investigated) Gene_expression (expression) of Bid associated with apoptosis
4) Confidence 0.27 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0.88 Pain Relevance 0
On the other hand, caspase-8 can induce Bid cleavage.
Gene_expression (cleavage) of Bid in cleavage
5) Confidence 0.23 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 1.32 Pain Relevance 0.03
Leptin delayed the cleavage of Bid and Bax, the mitochondrial release of cytochrome c and second mitochondria-derived activator of caspase, as well as the activation of both caspase-8 and caspase-3 in these cells [42].
Gene_expression (cleavage) of Bid in cleavage
6) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.23 Pain Relevance 0.07
Thus, the Bid cleavage
Gene_expression (cleavage) of Bid in cleavage
7) Confidence 0.17 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.40 Pain Relevance 0
A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid and Bim (O’Kane, 2006).
Gene_expression (expression) of Bid associated with apoptosis
8) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.34 Pain Relevance 0
A recent study similarly showed co-expression of the anti-apoptotic proteins Bcl-2, Bcl-XL and Mcl-1, with variable loss of expression of the anti-apoptotic Bad, Bak, Bax, Bid and Bim (O’Kane, 2006).
Gene_expression (expression) of Bid associated with apoptosis
9) Confidence 0.04 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.52 Pain Relevance 0
We have also undertaken investigations aiming at determination of the CD44s gene and its v6 isoform expression in intraductal and invasive pancreatic carcinoma, attempting to correlate this expression with the p53 gene mutations.
Gene_expression (expression) of v6 isoform associated with pancreatic cancer
10) Confidence 0.00 Published 1999 Journal Folia Med Cracov Section Abstract Doc Link 10909469 Disease Relevance 1.09 Pain Relevance 0

General Comments

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