INT89677

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 38
Total Number 39
Disease Relevance 13.98
Pain Relevance 8.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
brain stem 3
neurons 3
medulla 2
tail 2
colon 2
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 440 100.00 Very High Very High Very High
Spinal cord 109 99.56 Very High Very High Very High
dorsal root ganglion 46 99.44 Very High Very High Very High
long-term potentiation 39 99.36 Very High Very High Very High
medulla 88 99.28 Very High Very High Very High
Hyperalgesia 14 99.22 Very High Very High Very High
Kinase C 62 99.12 Very High Very High Very High
Dorsal horn 15 98.16 Very High Very High Very High
intrathecal 24 98.08 Very High Very High Very High
Inflammation 19 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Prostate Cancer 33 99.72 Very High Very High Very High
Ganglion Cysts 46 99.44 Very High Very High Very High
Cancer 165 99.40 Very High Very High Very High
Death 529 99.36 Very High Very High Very High
Hyperalgesia 17 99.22 Very High Very High Very High
Nociception 94 98.88 Very High Very High Very High
Natriuresis 3 98.48 Very High Very High Very High
Apoptosis 94 98.16 Very High Very High Very High
INFLAMMATION 33 97.00 Very High Very High Very High
Breast Cancer 10 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, although exisulind induced expression of PKG Ibeta, it did not elevate intracellular cGMP and its efficacy was not altered by inhibition or activation of PKG I.
Gene_expression (expression) of PKG Ibeta
1) Confidence 0.78 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.74 Pain Relevance 0.10
In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesterases, which elevates intracellular cGMP, and novel expression of cGMP-dependent protein kinase (PKG) Ibeta, the presumed downstream effector mediating apoptosis.
Gene_expression (expression) of cGMP-dependent protein kinase in colon associated with colon cancer and apoptosis
2) Confidence 0.78 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.77 Pain Relevance 0.12
In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesterases, which elevates intracellular cGMP, and novel expression of cGMP-dependent protein kinase (PKG) Ibeta, the presumed downstream effector mediating apoptosis.
Gene_expression (expression) of PKG in colon associated with colon cancer and apoptosis
3) Confidence 0.75 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.78 Pain Relevance 0.12
For example, it has been demonstrated that PKG1?
Gene_expression (demonstrated) of PKG
4) Confidence 0.65 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.10
Moreover, in recent studies, it was also established that PKG1?
Gene_expression (established) of PKG
5) Confidence 0.65 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0.15 Pain Relevance 0.03
Our results suggested that the four SNPs identified in this study were located within LD blocks that were part of the KCNMA1, SGCD, AKAP6, and PRKG1 genes and that did not extend beyond the gene boundaries.
Gene_expression (part) of PRKG1
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0
0.05) of type I (PRKG1, also known as PGK) at 10q11, and the SNP rs8013938 (p?
Gene_expression (at) of PRKG1
7) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0 Pain Relevance 0.09
subunits, is ubiquitous; the monomeric PKGII is expressed in various tissues such as the lung, kidney, testicle and brain. cGMP can also activate the cAMP pathway acting on the cAMP binding site and PKA (Tsukada et al 2002).


Gene_expression (expressed) of PKG in brain
8) Confidence 0.58 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518390 Disease Relevance 0.17 Pain Relevance 0.05
Alterations of PRKG1 have been implicated in the origin of clonal expansion of primary tumors from breast cancers [52], hepatocellular carcinomas [53] and uterine leiomyomas [54].
Gene_expression (Alterations) of PRKG1 in uterine associated with uterine fibroids, cancer, hepatocellular cancer and breast cancer
9) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 1.24 Pain Relevance 0
, consistent with the inhibitory effects of cAMP/PKA and cGMP/PKG on both the Ca2+-dependent and Ca2+-independent paths, it was apparent that at lower concentrations both Cicaprost (100 nM) and SIN-1 (500 nM) impaired F-actin polymerization in HEK.TP?
Gene_expression (effects) of PKG
10) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
is subject to regulation by both direct prostacyclin/PKA and NO/PKG-inhibition mediated through their respective phosphorylation of Ser329 and Ser331 within the unique C-tail domain of TP?
Gene_expression (/) of PKG in tail
11) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
signaling, they do so by entirely independent mechanisms involving direct PKA- and PKG- mediated phosphorylation of TP?
Gene_expression (signaling) of PKG
12) Confidence 0.32 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Consistent with this, KT 5823, the selective PKG inhibitor, significantly reduced U46619-induced phosphorylation of TP?
Gene_expression (selective) of PKG
13) Confidence 0.30 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.21
The level of PGK expression was comparable in all tissues.
Gene_expression (expression) of PGK
14) Confidence 0.26 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2727492 Disease Relevance 0.65 Pain Relevance 0
In addition, from our work in the pituitary field, and the work of others, we know that multiple estrogens induce activation of MAPKs.129,130 The estrogenic activation of other kinases likely to act on DAT’s N-terminal tail have yet to be investigated;93,131 these include PKA, PKG, the subtypes of PKC (?
Gene_expression (subtypes) of PKG in tail
15) Confidence 0.24 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0 Pain Relevance 0.13
Exisulind and analogs are inhibitors of cyclic GMP phosphodiesterases (PDE) and have been shown to increase kinase activity and induce the expression of protein kinase G (PKG).
Gene_expression (expression) of PKG
16) Confidence 0.22 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.33 Pain Relevance 0.51
Proper PRKG1 expression is important for proper brain development [44].
Gene_expression (expression) of PRKG1 in brain
17) Confidence 0.20 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853105 Disease Relevance 0.15 Pain Relevance 0.12
Formalin treatment resulted in a rapid (within 1h), long-lasting (up to 96h) upregulation of PKG-I protein expression.
Gene_expression (expression) of PKG
18) Confidence 0.16 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.23 Pain Relevance 0.33
To further evaluate this pathway we assessed the effects of the PKG-inhibiting cGMP analog Rp-8-Br-cGMPS in the rat formalin assay and analyzed the regulation of PKG expression in rat lumbar spinal cord.
Gene_expression (expression) of PKG in spinal cord associated with spinal cord
19) Confidence 0.16 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.26 Pain Relevance 0.22
Spinal delivery of 8-Br-cGMP, a PKG-activating cGMP analog, without subsequent formalin treatment also caused an increase of PKG-I protein expression.
Gene_expression (expression) of PKG in Spinal
20) Confidence 0.16 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.21 Pain Relevance 0.36

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