INT89678

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Context Info
Confidence 0.70
First Reported 2000
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 5.99
Pain Relevance 3.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PRKG1) signal transduction (PRKG1) plasma membrane (PRKG1)
cytoplasm (PRKG1)
Anatomy Link Frequency
Spinal 4
medulla 4
tail 4
colon 4
brain 2
PRKG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Rostral ventrolateral medulla 165 99.84 Very High Very High Very High
Hyperalgesia 5 99.46 Very High Very High Very High
medulla 33 99.28 Very High Very High Very High
cINOD 17 94.80 High High
Spinal cord 11 94.72 High High
Potency 2 94.08 High High
Morphine 4 93.72 High High
midbrain 1 92.76 High High
amygdala 2 91.92 High High
agonist 103 89.72 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 5 99.46 Very High Very High Very High
Apoptosis 36 99.36 Very High Very High Very High
Colon Cancer 26 98.36 Very High Very High Very High
Solid Tumor 4 96.04 Very High Very High Very High
Death 195 95.96 Very High Very High Very High
Nociception 13 91.88 High High
Urological Neuroanatomy 2 91.52 High High
Poisoning 21 91.12 High High
INFLAMMATION 9 90.24 High High
Cancer 91 81.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, although exisulind induced expression of PKG Ibeta, it did not elevate intracellular cGMP and its efficacy was not altered by inhibition or activation of PKG I.
Positive_regulation (induced) of Gene_expression (expression) of PKG Ibeta
1) Confidence 0.70 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.74 Pain Relevance 0.10
In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesterases, which elevates intracellular cGMP, and novel expression of cGMP-dependent protein kinase (PKG) Ibeta, the presumed downstream effector mediating apoptosis.
Positive_regulation (induction) of Gene_expression (expression) of cGMP-dependent protein kinase in colon associated with colon cancer and apoptosis
2) Confidence 0.50 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.80 Pain Relevance 0.13
For example, it has been demonstrated that PKG1?
Positive_regulation (demonstrated) of Gene_expression (demonstrated) of PKG
3) Confidence 0.49 Published 2007 Journal Biochim Biophys Acta Section Body Doc Link PMC2680961 Disease Relevance 0 Pain Relevance 0.10
In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesterases, which elevates intracellular cGMP, and novel expression of cGMP-dependent protein kinase (PKG) Ibeta, the presumed downstream effector mediating apoptosis.
Positive_regulation (induction) of Gene_expression (expression) of PKG in colon associated with colon cancer and apoptosis
4) Confidence 0.49 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.80 Pain Relevance 0.13
is subject to regulation by both direct prostacyclin/PKA and NO/PKG-inhibition mediated through their respective phosphorylation of Ser329 and Ser331 within the unique C-tail domain of TP?
Positive_regulation (direct) of Gene_expression (/) of PKG in tail
5) Confidence 0.24 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Exisulind and analogs are inhibitors of cyclic GMP phosphodiesterases (PDE) and have been shown to increase kinase activity and induce the expression of protein kinase G (PKG).
Positive_regulation (induce) of Gene_expression (expression) of PKG
6) Confidence 0.19 Published 2006 Journal Invest New Drugs Section Body Doc Link PMC2780666 Disease Relevance 0.33 Pain Relevance 0.51
In addition, from our work in the pituitary field, and the work of others, we know that multiple estrogens induce activation of MAPKs.129,130 The estrogenic activation of other kinases likely to act on DATÂ’s N-terminal tail have yet to be investigated;93,131 these include PKA, PKG, the subtypes of PKC (?
Positive_regulation (include) of Gene_expression (subtypes) of PKG in tail
7) Confidence 0.18 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0 Pain Relevance 0.13
Formalin treatment resulted in a rapid (within 1h), long-lasting (up to 96h) upregulation of PKG-I protein expression.
Positive_regulation (upregulation) of Gene_expression (expression) of PKG
8) Confidence 0.14 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.23 Pain Relevance 0.33
Spinal delivery of 8-Br-cGMP, a PKG-activating cGMP analog, without subsequent formalin treatment also caused an increase of PKG-I protein expression.
Positive_regulation (caused) of Gene_expression (expression) of PKG in Spinal
9) Confidence 0.14 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.21 Pain Relevance 0.36
Medium doses (0.5-1 micromol i.t.) had no effect and high doses (2.5 micromol i.t.) caused hyperalgesia associated with a further increase of PKG-I expression and a PKG-I clip.
Positive_regulation (increase) of Gene_expression (expression) of PKG associated with hyperalgesia
10) Confidence 0.14 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384231 Disease Relevance 0.41 Pain Relevance 0.37
Proper PRKG1 expression is important for proper brain development [44].
Positive_regulation (important) of Gene_expression (expression) of PRKG1 in brain
11) Confidence 0.12 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853105 Disease Relevance 0.15 Pain Relevance 0.12
A novel mechanism for exisulind to induce apoptosis is studied involving sustained increases in cGMP levels and cGMP-dependent protein kinase (PKG) induction not found with selective PDE5 or most other PDE inhibitors.
Positive_regulation (increases) of Gene_expression (induction) of PKG associated with apoptosis
12) Confidence 0.10 Published 2000 Journal Cancer Res. Section Abstract Doc Link 10910034 Disease Relevance 0.60 Pain Relevance 0.13
Spinal delivery of 8-Br-cGMP, a PKG-activating cGMP analog, without subsequent formalin treatment also caused an increase of PKG-I protein expression.
Positive_regulation (increase) of Gene_expression (expression) of PKG in Spinal
13) Confidence 0.09 Published 2003 Journal Nitric Oxide Section Abstract Doc Link 12620371 Disease Relevance 0.21 Pain Relevance 0.36
As reported previously [10-13], Western blot analysis revealed a significant augmentation of NOS I or PKG expression in ventrolateral medulla during the pro-life phase, followed by a return to baseline during the pro-death phase (fig. 3).
Positive_regulation (augmentation) of Gene_expression (expression) of PKG in medulla associated with medulla and death
14) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.50 Pain Relevance 0.31
Pretreating animals by microinjection into the bilateral RVLM of ERK activation inhibitor peptide II (1 nmol) or U0126 (5 pmol) significantly blunted the augmented NOS I or PKG protein expression at ventrolateral medulla during the pro-life phase (fig. 3).
Positive_regulation (augmented) of Gene_expression (expression) of PKG in medulla associated with medulla and rostral ventrolateral medulla
15) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.64 Pain Relevance 0.36
Our final series of experiments investigated whether activation of MNK1/2 is upstream to the augmented NOS I or PKG expression in RVLM during the pro-life phase.
Spec (whether) Positive_regulation (augmented) of Gene_expression (expression) of PKG associated with rostral ventrolateral medulla
16) Confidence 0.04 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2848001 Disease Relevance 0.37 Pain Relevance 0.39

General Comments

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