INT89714

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.43
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
trigeminal ganglion 2
DRG 2
inferior 2
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
inferior alveolar nerve 12 100.00 Very High Very High Very High
trigeminal ganglion 6 99.48 Very High Very High Very High
sodium channel 18 98.76 Very High Very High Very High
intrathecal 1 98.48 Very High Very High Very High
Neuropathic pain 4 98.16 Very High Very High Very High
hyperexcitability 4 97.32 Very High Very High Very High
Trigeminal ganglion neurons 4 96.48 Very High Very High Very High
Kinase C 2 89.44 High High
Sciatic nerve 2 85.48 High High
Root ganglion neuron 2 84.52 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 16 99.20 Very High Very High Very High
Ganglion Cysts 12 99.04 Very High Very High Very High
Neuropathic Pain 4 98.16 Very High Very High Very High
Injury 4 92.76 High High
Dysesthesia 2 83.92 Quite High
Nociception 5 83.88 Quite High
INFLAMMATION 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We here study the effect of chronic axotomy of the inferior alveolar nerve on the expression of SNS/PN3 mRNA in trigeminal sensory neurons.
Regulation (effect) of Transcription (expression) of PN3 in inferior associated with inferior alveolar nerve
1) Confidence 0.60 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 0.95 Pain Relevance 0.87
The changes in the levels of SNS/PN3 mRNA in the trigeminal ganglion, which follow the time course for hyperexcitability of trigeminal ganglion neurons after inferior alveolar nerve injury, may contribute to the inappropriate firing associated with sensory dysfunction in the orofacial region.
Regulation (changes) of Transcription (levels) of PN3 in trigeminal ganglion associated with ganglion cysts, inferior alveolar nerve, nervous system injury, trigeminal ganglion, hyperexcitability and trigeminal ganglion neurons
2) Confidence 0.26 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 0.98 Pain Relevance 0.71
The local treatment with dipyrone abolished this persistent hypernociception but did not alter the Na(V)1.8 mRNA level in the DRG.
Neg (not) Regulation (alter) of Transcription (level) of Na(V)1.8 in DRG
3) Confidence 0.26 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19073148 Disease Relevance 0.49 Pain Relevance 0.31

General Comments

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