INT89715

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Context Info
Confidence 0.60
First Reported 2000
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.81
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
trigeminal ganglion 1
DRG 1
Scn10a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nav1.2 2 100.00 Very High Very High Very High
trigeminal ganglion 3 99.48 Very High Very High Very High
sodium channel 10 98.76 Very High Very High Very High
nav1.8 2 98.32 Very High Very High Very High
intrathecal 1 97.60 Very High Very High Very High
hyperexcitability 2 97.32 Very High Very High Very High
Nav1.7 2 96.64 Very High Very High Very High
Trigeminal ganglion neurons 2 96.48 Very High Very High Very High
inferior alveolar nerve 6 95.12 Very High Very High Very High
Kinase C 2 89.44 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.04 Very High Very High Very High
Nervous System Injury 8 94.40 High High
Injury 134 89.16 High High
Nociception 5 83.88 Quite High
INFLAMMATION 10 75.00 Quite High
Neuropathic Pain 2 45.72 Quite Low
Dysesthesia 1 31.48 Quite Low
Spinal Cord Injury 38 5.00 Very Low Very Low Very Low
Spasticity 36 5.00 Very Low Very Low Very Low
Repression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The changes in the levels of SNS/PN3 mRNA in the trigeminal ganglion, which follow the time course for hyperexcitability of trigeminal ganglion neurons after inferior alveolar nerve injury, may contribute to the inappropriate firing associated with sensory dysfunction in the orofacial region.
Regulation (changes) of PN3 in trigeminal ganglion associated with ganglion cysts, inferior alveolar nerve, nervous system injury, trigeminal ganglion, hyperexcitability and trigeminal ganglion neurons
1) Confidence 0.60 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10915577 Disease Relevance 0.98 Pain Relevance 0.71
1 subunit (Scn10a, profile 8; Scn5a, profile 9; Scn1b, profile 8) exhibit late up-regulation, while only the gene coding for the a subunit Nav1.2 (Scn2a1) is down-regulated.
Regulation (regulation) of Scn10a associated with nav1.2
2) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.14 Pain Relevance 0.29
1 subunit (Scn10a, profile 8; Scn5a, profile 9; Scn1b, profile 8) exhibit late up-regulation, while only the gene coding for the a subunit Nav1.2 (Scn2a1) is down-regulated.
Regulation (regulated) of Scn10a associated with nav1.2
3) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.19 Pain Relevance 0.29
The local treatment with dipyrone abolished this persistent hypernociception but did not alter the Na(V)1.8 mRNA level in the DRG.
Neg (not) Regulation (alter) of Na(V)1.8 in DRG
4) Confidence 0.26 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19073148 Disease Relevance 0.49 Pain Relevance 0.31

General Comments

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