INT89729

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Context Info
Confidence 0.78
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.85
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sim2) signal transduction (Sim2) nucleus (Sim2)
DNA binding (Sim2) signal transducer activity (Sim2)
Sim2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 7 98.66 Very High Very High Very High
Inflammation 54 95.60 Very High Very High Very High
Pain 3 95.08 Very High Very High Very High
interstitial cystitis 1 86.96 High High
substance P 14 5.00 Very Low Very Low Very Low
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Down Syndrome 14 98.56 Very High Very High Very High
INFLAMMATION 66 98.48 Very High Very High Very High
Neurodegenerative Disease 4 96.64 Very High Very High Very High
Anxiety Disorder 2 92.60 High High
Congenital Anomalies 2 90.08 High High
Interstitial Cystitis 1 86.96 High High
Cancer 9 86.84 High High
Metastasis 1 86.08 High High
Targeted Disruption 2 83.84 Quite High
Generaliased Trisomy 6 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data therefore suggest that overexpression of SIM2 contributes to some of the complex DS phenotypes.
Gene_expression (overexpression) of SIM2 associated with down syndrome
1) Confidence 0.78 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 10915774 Disease Relevance 0.98 Pain Relevance 0.10
Three copies of SIM2 may contribute to some Down syndrome (DS) phenotypes because of the mapping position function as transcriptional repressor, temporal and spatial expression pattern of mouse Sim2, and the potentially analogous role of human SIM2 to that of Drosophila sim during neurogenesis.
Gene_expression (expression) of Sim2 associated with down syndrome and neurodegenerative disease
2) Confidence 0.78 Published 2000 Journal Hum. Mol. Genet. Section Abstract Doc Link 10915774 Disease Relevance 0.98 Pain Relevance 0
Our results indicated that several genes known to be part of the inflammatory response were found downstream of PAR1 activation (b2m, ccl7, cd200, cd63, cdbpd, cfl1, dusp1, fkbp1a, fth1, hspb1, marcksl1, mmp2, myo5a, nfkbia, pax1, plaur, ppia, ptpn1, ptprcap, s100a10, sim2, and tnfaip2).
Gene_expression (cdbpd) of sim2 associated with inflammatory response
3) Confidence 0.42 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853107 Disease Relevance 0.89 Pain Relevance 0.36

General Comments

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