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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Npr1) plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
smooth muscle 2
Npr1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 6 99.84 Very High Very High Very High
Inflammation 2 95.40 Very High Very High Very High
Morphine 4 94.40 High High
Inflammatory mediators 1 93.48 High High
cINOD 1 76.64 Quite High
MU agonist 1 74.88 Quite High
Neurotransmitter 1 70.28 Quite High
Antinociceptive 1 52.12 Quite High
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 4 95.40 Very High Very High Very High
Nociception 4 89.32 High High
Ileus 4 77.92 Quite High
Intestinal Pseudo-obstruction 4 75.00 Quite High
Critical Illness 1 45.04 Quite Low
Sepsis 1 44.20 Quite Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that thiamine could produce antinociception by the activation of guanylyl cyclase mediated by cyclic guanosine monophosphate (cGMP) that may trigger the possible involvement of central and/or peripheral L-arginine/NO/cGMP pathway.
Positive_regulation (mediated) of Positive_regulation (activation) of guanylyl cyclase associated with antinociception
1) Confidence 0.47 Published 2000 Journal Arzneimittelforschung Section Abstract Doc Link 10918950 Disease Relevance 0.24 Pain Relevance 0.89
Next, we provide evidence that production of iNOS results in the activation of guanylyl cyclase leading to the production of cGMP and smooth muscle relaxation.
Positive_regulation (leading) of Positive_regulation (activation) of guanylyl cyclase in smooth muscle
2) Confidence 0.19 Published 2003 Journal Verh. K. Acad. Geneeskd. Belg. Section Abstract Doc Link 14671847 Disease Relevance 0.66 Pain Relevance 0.31

General Comments

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