INT89756

Context Info Confidence 0.47 First Reported 2000 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.90 Pain Relevance 1.19

lyase activity (Npr1) plasma membrane (Npr1) intracellular (Npr1)

Anatomy Link Frequency smooth muscle 2 Npr1 (Mus musculus)

Pain Link Frequency Relevance Heat antinociception 6 99.84 Inflammation 2 95.40 Morphine 4 94.40 Inflammatory mediators 1 93.48 cINOD 1 76.64 MU agonist 1 74.88 Neurotransmitter 1 70.28 Antinociceptive 1 52.12 Pain 3 25.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 95.40 Nociception 4 89.32 Ileus 4 77.92 Intestinal Pseudo-obstruction 4 75.00 Critical Illness 1 45.04 Sepsis 1 44.20 Stress 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The present results suggest that thiamine could produce antinociception by the activation of guanylyl cyclase mediated by cyclic guanosine monophosphate (cGMP) that may trigger the possible involvement of central and/or peripheral L-arginine/NO/cGMP pathway.

Positive_regulation (mediated) of Positive_regulation (activation) of guanylyl cyclase associated with antinociception

1) Confidence 0.47 Published 2000 Journal Arzneimittelforschung Section Abstract Doc Link 10918950 Disease Relevance 0.24 Pain Relevance 0.89

Next, we provide evidence that production of iNOS results in the activation of guanylyl cyclase leading to the production of cGMP and smooth muscle relaxation.

Positive_regulation (leading) of Positive_regulation (activation) of guanylyl cyclase in smooth muscle

2) Confidence 0.19 Published 2003 Journal Verh. K. Acad. Geneeskd. Belg. Section Abstract Doc Link 14671847 Disease Relevance 0.66 Pain Relevance 0.31

General Comments

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