INT89769

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Context Info
Confidence 0.69
First Reported 2000
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.83
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A1) signal transduction (NR4A1) nucleus (NR4A1)
DNA binding (NR4A1)
Anatomy Link Frequency
T-lymphocytes 2
NR4A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 92.52 High High
Central nervous system 1 81.52 Quite High
Clonidine 5 32.40 Quite Low
alcohol 1 29.40 Quite Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 24 99.48 Very High Very High Very High
Death 15 98.44 Very High Very High Very High
Colon Cancer 7 98.32 Very High Very High Very High
Apoptosis 33 98.04 Very High Very High Very High
Lymphatic System Cancer 6 97.54 Very High Very High Very High
Cancer 69 93.88 High High
INFLAMMATION 2 91.96 High High
Immunization 4 87.04 High High
Pancreatic Cancer 24 72.36 Quite High
Uterine Fibroids 72 60.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report that indomethacin induced the expression of Nur77 which has been implicated in activation-induced apoptosis of T-lymphocytes, in a colon cancer cell line, HCT-15.
Positive_regulation (induced) of Gene_expression (expression) of Nur77 in T-lymphocytes associated with colon cancer and apoptosis
1) Confidence 0.69 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 0.87 Pain Relevance 0.18
Thus, increased expression of NR4A1 and elevated levels of RA in response to estrogen could promote cell proliferation and suppress pro-apoptosis activity.
Positive_regulation (increased) of Gene_expression (expression) of NR4A1 associated with rheumatoid arthritis and apoptosis
2) Confidence 0.36 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.08 Pain Relevance 0.04
Interestingly, treatment of CTCL with panobinostat (LBH589, Novartis Pharmaceuticals Basle, Switzerland) inhibits the mRNA and protein levels of HDAC7 and induces expression and translocation of Nur77 to the mitochondria where it converts death resistance protein BCL-2 into a killer protein, therefore leading to the death of cultured and patient-derived human CTCL cells [72].
Positive_regulation (induces) of Gene_expression (expression) of Nur77 associated with lymphatic system cancer and death
3) Confidence 0.11 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.74 Pain Relevance 0
hormone receptor, the assay may be used to estimate
Positive_regulation (estimate) of Gene_expression (used) of hormone receptor
4) Confidence 0.06 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.14 Pain Relevance 0

General Comments

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