INT89774

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Context Info
Confidence 0.77
First Reported 2000
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 21
Disease Relevance 9.47
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR4A1) signal transduction (NR4A1) nucleus (NR4A1)
DNA binding (NR4A1)
Anatomy Link Frequency
T lymphocyte 3
uterine 2
eye 1
uterus 1
melanocytes 1
NR4A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 8 95.76 Very High Very High Very High
cINOD 5 92.04 High High
Enkephalin 2 85.12 High High
Nerve growth factor 2 82.76 Quite High
Central nervous system 2 82.36 Quite High
melanocortin 1 receptor 2 75.00 Quite High
Somatostatin 2 74.52 Quite High
Neuritis 9 71.36 Quite High
Neuropeptide 4 68.28 Quite High
alcohol 20 60.88 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 47 99.08 Very High Very High Very High
Endometrial Cancer 2 98.90 Very High Very High Very High
Carcinoma 9 98.80 Very High Very High Very High
Death 18 98.44 Very High Very High Very High
Reprotox - General 1 16 98.36 Very High Very High Very High
Leiomyosarcoma 118 98.04 Very High Very High Very High
Apoptosis 52 98.04 Very High Very High Very High
Cancer 304 97.88 Very High Very High Very High
Colon Cancer 30 97.84 Very High Very High Very High
Deafness 9 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we report that indomethacin induced the expression of Nur77 which has been implicated in activation-induced apoptosis of T-lymphocytes, in a colon cancer cell line, HCT-15.
Gene_expression (expression) of Nur77 in T-lymphocytes associated with colon cancer and apoptosis
1) Confidence 0.77 Published 2000 Journal Biol. Pharm. Bull. Section Abstract Doc Link 10919358 Disease Relevance 0.87 Pain Relevance 0.18
short-latency negative (n10) myogenic potentials, recorded
Neg (negative) Gene_expression (negative) of n10
2) Confidence 0.43 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0 Pain Relevance 0
between subjects in the amplitude of that n10 potential as
Gene_expression (potential) of n10
3) Confidence 0.43 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0 Pain Relevance 0
The n10 AR values for healthy subjects and uVL patients
Gene_expression (values) of n10
4) Confidence 0.43 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0 Pain Relevance 0
Using small interference RNA-mediated attenuation of NR4A1 and NR4A2 expression in melanocytes, the ability to remove cyclobutane pyrimidine dimers following UV irradiation appeared to be impaired in the context of MC1R signaling.
Gene_expression (expression) of NR4A1 in melanocytes
5) Confidence 0.43 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18292087 Disease Relevance 0.30 Pain Relevance 0.18
Thus, increased expression of NR4A1 and elevated levels of RA in response to estrogen could promote cell proliferation and suppress pro-apoptosis activity.
Gene_expression (expression) of NR4A1 associated with rheumatoid arthritis and apoptosis
6) Confidence 0.40 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.07 Pain Relevance 0.04
closer to the recording electrodes 13 16 the size of the n10
Gene_expression (size) of n10
7) Confidence 0.38 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0.07 Pain Relevance 0
The n10 is distinct from the R1 component
Gene_expression (The) of n10
8) Confidence 0.38 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0.10 Pain Relevance 0
In healthy subjects, n10 responses were of
Gene_expression (responses) of n10
9) Confidence 0.38 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0 Pain Relevance 0.03
EMG response (n10) and a latency of around 10 ms
Gene_expression (response) of n10
10) Confidence 0.38 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0 Pain Relevance 0.03
by the surgeon) and may, therefore, produce the n10 ocular
Gene_expression (produce) of n10
11) Confidence 0.34 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Body Doc Link PMC3008154 Disease Relevance 0 Pain Relevance 0
asymmetries were observed between the n10 beneath the two eyes: n10 is small or absent beneath the eye on the side opposite the operated
Neg (absent) Gene_expression (absent) of n10 in eye
12) Confidence 0.34 Published 2010 Journal Acta Otorhinolaryngologica Italica Section Abstract Doc Link PMC3008154 Disease Relevance 0.07 Pain Relevance 0.07
It is worthwhile to note that directions of expression changes of ANXA1, NR4A1 and PLP1 were opposite from that of the estrogen treated rat uterus.
Gene_expression (expression) of NR4A1 in uterus
13) Confidence 0.31 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 0.84 Pain Relevance 0.04
Interestingly, treatment of CTCL with panobinostat (LBH589, Novartis Pharmaceuticals Basle, Switzerland) inhibits the mRNA and protein levels of HDAC7 and induces expression and translocation of Nur77 to the mitochondria where it converts death resistance protein BCL-2 into a killer protein, therefore leading to the death of cultured and patient-derived human CTCL cells [72].
Gene_expression (expression) of Nur77 associated with lymphatic system cancer and death
14) Confidence 0.15 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.74 Pain Relevance 0
Furthermore, the biochemical methods have been abandoned to the detriment of immunohistochemical methods for hormone receptor assessment in an increasing number of pathology laboratories.
Gene_expression (assessment) of hormone receptor
15) Confidence 0.09 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.64 Pain Relevance 0
hormone receptor, the assay may be used to estimate
Gene_expression (used) of hormone receptor
16) Confidence 0.08 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0.14 Pain Relevance 0
The thymic RE cell network is most probably comprised of cells organized into sub-networks--functional units composed of RE cells with differing hormone production/hormone receptor expression profiles, involved in the various stages of T lymphocyte maturation.
Gene_expression (expression) of hormone receptor in T lymphocyte
17) Confidence 0.07 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0.23
Furthermore, it is quite possible that even on the level of individual RE cells, the numerous projections associated with a single cell, which engulf developing lymphocytes, nurturing and guiding them in their maturation, may differ in their hormone production and/or hormone receptor expression profile, thus allowing a single cell to be involved in distinct, separate steps of the T cell maturation process.
Gene_expression (expression) of hormone receptor in T cell
18) Confidence 0.07 Published 2000 Journal Anticancer Res. Section Abstract Doc Link 10928121 Disease Relevance 0 Pain Relevance 0.16
Although gynecological cancers, for instance, breast cancer and endometrial carcinomas, are stongly promoted by female hormones, the rate of hormone receptor expression is reported to be significantly less in uterine LMS than in normal uterine smooth muscle (USM).
Gene_expression (expression) of hormone receptor in uterine associated with leiomyosarcoma, cancer, endometrial cancer and reprotox - general 1
19) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 1.83 Pain Relevance 0.03
Gynecological cancer, for instance breast cancer and endo-metrial carcinomas, are strongly promoted by female hormones, but the rate of hormone receptor expression is reported to be significantly less in human uterine LMS compared with normal USM cells.
Gene_expression (expression) of hormone receptor in uterine associated with leiomyosarcoma, cancer, carcinoma and reprotox - general 1
20) Confidence 0.06 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 1.73 Pain Relevance 0

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