INT89776

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2005
Negated 1
Speculated 1
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 2.84
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a) signal transduction (Pde2a) Golgi apparatus (Pde2a)
endoplasmic reticulum (Pde2a) plasma membrane (Pde2a) nucleus (Pde2a)
Anatomy Link Frequency
heart 1
Pde2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antinociception 2 99.54 Very High Very High Very High
Antinociceptive 4 98.80 Very High Very High Very High
Clonidine 1 91.68 High High
agonist 16 91.28 High High
Hyperalgesia 2 87.84 High High
ischemia 7 83.60 Quite High
Spinal cord 2 60.20 Quite High
intrathecal 1 53.96 Quite High
fibrosis 14 46.80 Quite Low
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Coronary Heart Disease 140 97.68 Very High Very High Very High
Injury 63 96.92 Very High Very High Very High
Cardiovascular Disease 7 90.48 High High
Natriuresis 28 85.44 High High
Nociception 4 85.16 High High
Cv Unclassified Under Development 7 83.60 Quite High
Reprotox - General 2 21 80.52 Quite High
Hyperalgesia 2 64.40 Quite High
Pressure And Volume Under Development 14 49.76 Quite Low
Hypertrophy 35 48.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, 8-bromo-cGMP evoked antinociception appears to be largely independent of PKG-I, CNGs, PDE2 and PDE3.
Neg (independent) Spec (appears) Positive_regulation (independent) of PDE2 associated with antinociception
1) Confidence 0.47 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12384231 Disease Relevance 0.28 Pain Relevance 0.60
In those studies, opening of mitochondrial ATP-sensitive K channels, induction of NO synthase (NOS) isoforms and increased cGMP level by sildenafil were suggested to mediate a preconditioning-like cardioprotective effect [2-4].
Positive_regulation (induction) of cGMP
2) Confidence 0.15 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.43 Pain Relevance 0
Indomethacin at 5 microM significantly elevated CPT-cAMP-stimulated P(f), J(lb), and P(u), and subsequent addition of 100 nM PGE(2) reduced these transport parameters.
Positive_regulation (elevated) of CPT-cAMP-stimulated
3) Confidence 0.11 Published 2000 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 10919849 Disease Relevance 0 Pain Relevance 0.17
Consequently, PDE-5A inhibition by sildenafil and cellular accumulation of cGMP would be the braking force against isoproterenol-induced cardiac hypertrophy found in the present study.
Positive_regulation (accumulation) of cGMP associated with coronary heart disease
4) Confidence 0.10 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.40 Pain Relevance 0
In those studies, opening of mitochondrial ATP-sensitive K channels, induction of NO synthase (NOS) isoforms and increased cGMP level by sildenafil were suggested to mediate a preconditioning-like cardioprotective effect [2-4].
Positive_regulation (increased) of cGMP
5) Confidence 0.10 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.43 Pain Relevance 0
At cellular level, the common denominator in all these studies is probably the increased cellular level of cGMP.
Positive_regulation (increased) of cGMP
6) Confidence 0.10 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.38 Pain Relevance 0.04
The second messenger cGMP that was identified almost 40 years ago, is generated from GTP either by soluble guanyl cyclase or particulate guanyl cyclase [20].
Positive_regulation (generated) of cGMP
7) Confidence 0.10 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.22 Pain Relevance 0
Elevated myocardial cGMP was found in two sildenafil groups (III and IV) compared to other groups (I, II and V).


Positive_regulation (Elevated) of cGMP
8) Confidence 0.10 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1131906 Disease Relevance 0.23 Pain Relevance 0
Sildenafil citrate increases myocardial cGMP content in rat heart, decreases its hypertrophic response to isoproterenol and decreases myocardial leak of creatine kinase and troponin T

Background

Positive_regulation (increases) of cGMP in heart
9) Confidence 0.10 Published 2005 Journal BMC Pharmacol Section Title Doc Link PMC1131906 Disease Relevance 0.46 Pain Relevance 0

General Comments

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